|
Idiopathic Membranous Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The associations of single nucleotide polymorphisms (SNPs) in PLA2R1 and HLA-DQA1, as well as HLA-DRB1*15:01-DQB1*06:02 haplotype with idiopathic membranous nephropathy (IMN) is well known.
|
30349113 |
2018 |
|
Idiopathic Membranous Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There were no correlations between PLA2R1 and HLA-DQA1 sequence variants and clinical parameters in patients with iMN.
|
28849274 |
2018 |
|
Idiopathic Membranous Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The pooled odds ratios (ORs) regarding the association between the HLA-DQA1 rs2187668 polymorphism and iMN risk were statistically significant [A vs G: OR = 3.34, 95% confidence interval (CI) = 2.70-4.13; AA vs GA + GG: OR = 8.69, 95% CI = 6.64-11.36; GG vs GA + AA: OR = 0.25, 95% CI = 0.19-0.33;AA vs GG: OR = 12.61, 95% CI = 8.02-19.81; GA vs GG: OR = 3.45, 95% CI = 2.79-4.25].
|
30383665 |
2018 |
|
Idiopathic Membranous Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
HLA-DQA1 had been identified to be associated with IMN in Europeans and the result was replicated in Chinese Han population.
|
28685717 |
2017 |
|
Idiopathic Membranous Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study validated the association of these HLA-DQA1 and PLA2R1 SNPs with IMN in a Spanish cohort and its increased risk when combining both risk genotypes.
|
24262501 |
2014 |
|
Idiopathic Membranous Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have demonstrated that alleles at single nucleotide polymorphisms (SNPs) rs2187668 and rs4664308 within genes HLA-DQA1 and PLA2R1, respectively, had a significant impact on the susceptibility to idiopathic membranous nephropathy (IMN).
|
23194743 |
2013 |
|
Idiopathic Membranous Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The genetic susceptibility of IMN has been accounted for by HLA DQA1 and PLA2R1 genes.
|
23364522 |
2013 |
|
Idiopathic Membranous Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our recent genome-wide association study showed that genetic variants in an HLA-DQA1 and phospholipase A2 receptor (PLA2R1) allele associate most significantly with biopsy-proven iMN, suggesting that rare genetic variants within the coding region of the PLA2R1 gene may contribute to antibody formation.
|
23431073 |
2013 |
|
Idiopathic Membranous Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the interaction between PLA2R1 and HLA-DQA1 risk alleles associates with the development of IMN in the Chinese population.
|
23813219 |
2013 |
|
Idiopathic Membranous Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A genome-wide association study has provided further evidence for a highly significant association between PLA2R1 and HLA-DQA1 loci and idiopathic membranous nephropathy in patients of white ancestry.
|
22371247 |
2012 |
|
Idiopathic Membranous Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In African Americans, much of the risk for end-stage nondiabetic kidney disease is explained by common variants in the MYH9/APOL1 locus, and in individuals of European descent, variants in HLA-DQA1 and PLA(2)R1 implicate most of the risk for idiopathic membranous nephropathy.
|
21691125 |
2011 |
|
Idiopathic Membranous Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An HLA-DQA1 allele on chromosome 6p21 is most closely associated with idiopathic membranous nephropathy in persons of white ancestry.
|
21323541 |
2011 |
|
Idiopathic Membranous Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
CTD_human |
HLA-DRB1*0301 and DQA1*0501 in RA.
|
11436868 |
2001 |
|
Idiopathic Membranous Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The incidence of DQA1*0501 was raised in both Greek (96% vs. 66%, OR 9.7, chi 2 6.9, P = 0.009) and British IMN (85% vs. 45%, OR 7.4, chi 2 20, P = 0.00007) patients.
|
7605775 |
1995 |
|
Idiopathic Membranous Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A DQA1 allele is strongly associated with idiopathic membranous nephropathy.
|
2576474 |
1989 |