Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Frequencies of HLA-DQB1 amino acids differentiate between APS-2 T1D/AIT and AD/AIT. 30590628 2019
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Umbilical cord serum samples from 764 children born from 1994 to 2004 with HLA-DQB1 conferred risk for T1D participating in the Type 1 Diabetes Prediction and Prevention Study were analyzed for 25(OH)D using an enzyme immunoassay. 30657906 2019
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE A prospective population-based cohort of 6081 Finnish newborn infants with HLA-DQB1-conferred susceptibility to T1D was followed up to 15 years of age. 31123290 2019
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease GWASCAT Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two-Stage Genome-Wide Association Study. 31152121 2019
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE There was a possible association in the NIMA HLA-DQB1*03:01 subgroup with later T1D (aOR 3.89, 95%CI 1.05-14.4). 31173445 2019
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE HLA-DQB1*03:01 and -DQB1*03:02 were associated with a higher risk of developing T1D and APS3v; HLA-DQB1*02 was significantly more present among APS3v patients while HLA-DQB1*03:03 was observed with a significantly lower frequency only among T1D patients. 29958949 2018
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Combined effect of glutamine at position 70 of HLA-DRB1 and alanine at position 57 of HLA-DQB1 in type 1 diabetes: An epitope analysis. 29494662 2018
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Increased risk is assessed using three single nucleotide polymorphisms for HLA DRB1*03 (DR3), HLA DRB1*04 (DR4), HLA DQB1*0302 (DQ8) alleles, and defined as 1. an HLA DR3/DR4-DQ8 or DR4-DQ8/DR4-DQ8 genotype or 2. an HLA DR4-DQ8 haplotype and a first-degree family history of type 1 diabetes. 29121687 2018
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE HLA-DQA1 positive for Arginine at position 52 (Arg52) (OR = 15.2) and HLA-DQB1 negative for Aspartic acid at the position 57 (Asp57) (OR = 9.0) alleles appear to be important genetic markers for T1D susceptibility, with higher odds ratio values than any single allele and than most of the haplotypes. 28834219 2017
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE A total of 104 four-digit and 92 two-digit HLA allele phenotype associations were significant in both discovery and replication cohorts, the strongest being <i>HLA-DQB1*03:02</i> and type 1 diabetes. 28490672 2017
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE To determine the frequency of HLA-DQB1*0201/02 and DQB1*0302 alleles and anti-tTG seropositivity in children with T1DM. 27543737 2017
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE HLA-B (n=395), HLA-DRB1 (n=501) and HLA-DQB1 (n=475) alleles were genotyped in pregnant women (mothers of children who later developed type 1 diabetes and mothers of non-diabetic children). 27623983 2017
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE AA residue at position 57 in HLA-DQB1, the most significant position in type I diabetes mellitus, showed the strongest association among AA residues. 27241705 2016
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Those children found to be autoantibody-positive were invited to follow-up examinations and HLA-DQB1 genotyping, and were followed for progression to Type 1 diabetes. 25523979 2015
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease CTD_human Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk. 26168013 2015
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE One hundred and one children with type 1 diabetes and 160 healthy controls from the same region were studied for HLA-DQB1, HLA-DQA1, and HLA-DRB1 (DR4 subtypes) alleles; for INS and protein tyrosine phosphatase, non-receptor type 22 gene polymorphisms (rs689 and rs2476601); and for diabetes-associated autoantibodies. 25256132 2015
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE This study aimed to determine the HLA-DRB1/HLA-DQB1 susceptibility and protection pattern for type 1 diabetes (T1D) in a population from Hamadan, north-west of Iran. 26088816 2015
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE This study aimed at assessing the nature and significance of associations between various alleles of HLA-DQA1, HLA-DQB1, and type I diabetes (T1D) in Arab populations. 26095634 2015
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Previous studies of isolated T1D and of T1D combined with other autoimmune disorders showed genetic susceptibility for alleles in HLA-DQB1 and -DRB1 and also CTLA4 and PTPN22. 26405068 2015
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE IDDM1 and IDDM 2 as well as autoreactive T cells may contribute to the development of T1DM. 24971665 2014
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE We show that HERV-K(C4) is a novel marker of type 1 diabetes that accounts for the disease association previously attributed to some key HLA-DQB1 alleles, raising the possibility that this retroviral insertion element contributes to functional protection against type 1 diabetes. 24430436 2014
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Young age, higher BMI SDS, reduced FPIR and higher levels of IAA and IA-2A predicted T1D in young children with HLA-DQB1-conferred disease susceptibility and advanced β-cell autoimmunity. 23904276 2013
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Here, we studied umbilical cord serum lipidome in infants who later developed T1D (N = 33); infants who developed three or four (N = 31) islet autoantibodies, two (N = 31) islet autoantibodies, or one (N = 48) islet autoantibody during the follow-up; and controls (N = 143) matched for sex, HLA-DQB1 genotype, city of birth, and period of birth. 23630305 2013
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Owing to strong linkage disequilibrium between markers, pinpointing disease associations within genetic regions is difficult in European ancestral populations, most notably the very strong association of the HLA-DRB1*03-DQA1*05:01-DQB1*02:01 haplotype with Type 1 diabetes risk, which is assumed to be because of a combination of HLA-DRB1 and HLA-DQB1. 23398374 2013
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE The primary associations of the HLA class II genes, HLA-DRB1 and HLA-DQB1, and the class I genes, HLA-A and HLA-B, with type 1 diabetes (T1D) are well established. 23462545 2013