Diabetes Mellitus, Non-Insulin-Dependent
|
0.190 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
A family history for both type 1 and type 2 diabetes was associated with higher prevalence of GAD antibodies and HLA-DQB1 risk genotypes than a family history of type 2 diabetes only, and was associated with earlier and more severe development of insulin deficiency, which was only partially explained by GAD antibodies and HLA.
|
23157220 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.190 |
GeneticVariation
|
disease |
LHGDN |
HLA DRB1, DQB1 and insulin promoter VNTR polymorphisms: interactions and the association with adult-onset diabetes mellitus in Czech patients.
|
18279373 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
Our data suggested that HLA-DQB1 alleles of all three risk classes, INS variable number of tandem repeat (VNTR) I/I and CTLA-4 +49 GG or AG genotypes, were independent risk factors for developing LADA and could be used as a diagnostic tool to discriminate between LADA and T2D.
|
17257313 |
2007 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.190 |
Biomarker
|
disease |
BEFREE |
However, in patients without islet antibodies, HLA-DQB1 genotyping together with C-peptide measurement may be of value in differentiating between idiopathic type 1 diabetes and type 2 diabetes.
|
16783473 |
2006 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
To study whether the TNF alpha gene could be such a modifying gene, we studied TNF alpha promoter polymorphisms (G-->A substitution at positions -308 and -238) in relation to HLA-DQB1 genotypes in type 2 patients from mixed type 1/2 families or common type 2 diabetes families as well as in patients with adult-onset type 1 diabetes and control subjects.
|
12788886 |
2003 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.190 |
GeneticVariation
|
disease |
LHGDN |
To study whether the TNF alpha gene could be such a modifying gene, we studied TNF alpha promoter polymorphisms (G-->A substitution at positions -308 and -238) in relation to HLA-DQB1 genotypes in type 2 patients from mixed type 1/2 families or common type 2 diabetes families as well as in patients with adult-onset type 1 diabetes and control subjects.
|
12788886 |
2003 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.190 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the occurrence of T1D in 253 Lebanese Caucasian patients, in relation to HLA-DQB1*0201, HLA-DQB1*0302, HLA-DQB1*0602, gender, and early exposure to cow's milk, as well as to family history of T1D and type-2 diabetes (T2D).
|
12107223 |
2002 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.190 |
Biomarker
|
disease |
BEFREE |
We present the case of a well characterised M.O.D.Y. type 2 diabetes family in which one of the children associated beta cell autoimmunity and a HLA DQB1 at risk for immune-mediated type 1 diabetes mellitus.
|
11240447 |
2001 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we studied the frequency of GAD antibodies (GADabs), HLA-DQB1 risk genotypes, and the presence of coronary heart disease (CHD) according to family history in unrelated patients with type 2 diabetes from 787 families (148 FH-, 546 FH+(TYPE2) and 93 FH+(MIXED)).
|
10834414 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
A missense mutation of R272H (replacement of Arg by His in codon 272) in the DNA binding domain of HNF-1 alpha was found in a subject who developed IDDM 1 year after diagnosis of NIDDM at 8 years of age.
|
9313763 |
1997 |