Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Thus the DRB1 locus probably cannot account for the DR4 association in IDDM. 3260586 1988
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Subtypes of HLA-DQ and -DR defined by DQB1 and DRB1 RFLPs: allele frequencies in the general population and in insulin-dependent diabetes (IDDM) and multiple sclerosis patients. 2576190 1989
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE We find that (a) IDDM is approximately equally associated with alleles of the DRB1 locus (Dw4 and Dw10, combined relative risk, RR = 6.4) and the DQB1 locus (DQ3.2, RR = 5.9); and (b) there is significant interaction, in a statistical sense, between these DR and DQ alleles in IDDM. 2784133 1989
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE The DRB1 gene, particularly position 57 of the DR beta-chain, may contribute to IDDM susceptibility in Japanese. 2227136 1990
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE These results suggest that it is the conventional DQB1 allele (*0602) not the DRB1 allele (*1501) on the protective DR2 haplotype that confers protection in the general population and, furthermore, that these unusual DQB1 alleles may confer susceptibility to IDDM in this family. 2010048 1991
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE We have studied 87 unrelated Caucasian insulin-dependent diabetes mellitus (IDDM) patients and 181 healthy controls by oligotyping for 20 DRB1, eight DQA1 and 13 DQB1 alleles, and established their DR-DQ haplotypes and DQ genotypes. 1908143 1991
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE These data indicate that DRB1 and DQA1 genes also confer susceptibility to Type 1 diabetes in Japanese. 1521722 1992
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE This observation and its comparison with DR-DQ haplotypes in other ethnic groups suggest that the DRB1*0405 allele which encodes an Asp57-negative beta chain may contribute to IDDM susceptibility in a similar way as Asp57-negative DQ beta chains. 1477090 1992
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Comparison between HLA-DRB and DQ DNA sequences and classic serological markers as type 1 (insulin-dependent) diabetes mellitus predictive risk markers in the Spanish population. 1355747 1992
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Combinations of specific DRB1, DQA1, DQB1 haplotypes are associated with insulin-dependent diabetes mellitus in Sardinia. 8226139 1993
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The frequencies of HLA-DQA1, DQB1 and DRB1 alleles were compared between 50 Insulin-Dependent Diabetes Melitus (IDDM) patients and 49 healthy controls in the Greek population. 8338816 1993
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Association of insulin-dependent diabetes mellitus in Taiwan with HLA class II DQB1 and DRB1 alleles. 8106265 1993
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE The general pattern of neutral and protective haplotypes indicates that the presence of Asp-57 in the HLA-DQ beta chain does not confer IDDM protection per se and indicates that both DRB1 and DQB1 influence IDDM susceptibility as well as protection. 7981758 1993
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE In conclusion, of the five subtypes of DR2, only one, the DRB1*1501, DRB5*0101, DQB1*0602-DQA1*0102 haplotype, was negatively associated with IDDM. 7817375 1994
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Our findings confirm that protection against IDDM is provided by HLA-DQ loci but that susceptibility for IDDM is provided by both HLA-DRB1 and DQB1 loci. 7834277 1994
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE A second high risk haplotype, DRB1*0401-DQB1*0302 encoding the DR4-DQ8 serologic specificity, accounted for increased susceptibility both in the total insulin-dependent diabetic population and among DR4-positive patients. 7988783 1994
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE We examined the prevalence of HLA-DRB1, DQB1, DQA1 and TAP2 genes in children with insulin-dependent diabetes mellitus (type 1 diabetes). 8002038 1994
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Further analysis suggested that TAP2C was in LD with HLA-DRB1*1401 and subtypes of HLA-DRB1*11, alleles which were not observed in the IDDM population. 7871524 1994
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE In Japanese, DRB1*0405-DQA1*0301-DQB1*0401, DRB1*0901-DQA1*0301-DQB1*0303 and DRB1*0802-DQA1*0301-DQB1*0302 are the major susceptibility haplotypes to IDDM, while DRB1*1501-DQA1*0102-DQB1*0602 and DRB1*1502-DQA1*0103-DQB1*0601 are the major resistance haplotypes. 7859639 1994
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The distribution of DR4 haplotypes in Sardinia suggests a primary association of type I diabetes with DRB1 and DQB1 loci. 7499178 1995
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE This included: Norwegian subjects with Celiac disease and the HLA DRB1*0301, DQA1*05011, DQB1*02 haplotype; Japanese subjects with Type 1 (insulin-dependent) Diabetes Mellitus and the HLA DRB1*0405, DQA1*0302, DQB1*0401 haplotype; and French patients with corticosensitive Idiopathic Nephrotic Syndrome and the HLA DRB1*0701, DQA1*0201, DQB1*0202 haplotype. 8560448 1995
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Among all DR4 subtypes, only DRB1*0405 was associated with the increased risk of IDDM. 8722074 1995
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The strong linkage disequilibrium observed between DQB1*0302 and DRB1*0403(0406) can thus explain the surprising finding that the frequency of DQB1*0302 was not significantly increased in the Chinese IDDM patients (RR = 0.9). 8770634 1995
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE In most cases the data showed this HLA DP allele combination as a part of the HLA DRB1*03-DQA1*0501-DQB1*0201 haplotype positively associated with IDDM, indicating a linkage disequilibrium between the alleles involved in this HLA DR-DQ-DP haplotype and as a consequence, a secondary role of HLA-DP genes in conferring susceptibility to the development of the disease. 7576003 1995
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE DRB1*0404, which was decreased in frequency in IDDM subjects, occurred in association significantly more frequently with DQB1*0302 in controls. 7495781 1995