Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The HLA DRB1*15:01 allele, which affords dominant protection against Type 1 diabetes, was found in one participant, who had multiple islet autoantibodies and carried the rs7903146 TT genotype. 27027642 2017
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The frequency of HLA-DRB1 risk alleles for type 1 diabetes is significantly lower in patients with MODY. 28052112 2017
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE In addition to confirming known associations, a systemic lupus erythematosus-associated risk variant at TNXB was also associated with CKD attributed to type 1 diabetes (p = 2.5 × 10<sup>-</sup><sup>7</sup>), a membranous nephropathy-associated variant at HLA-DQA1 was also associated with CKD attributed to systemic lupus erythematosus (p = 5.9 × 10<sup>-</sup><sup>6</sup>), and an IgA risk variant at HLA-DRB1 was associated with both CKD attributed to granulomatosis with polyangiitis (p = 2.0 × 10<sup>-4</sup>) and to type 1 diabetes (p = 4.6 × 10<sup>-11</sup>). 29066732 2017
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Predisposition to T1D conferred by PTPN22 and INS-VNTR and protection against T1D conferred by the DRB1*16 allele were confirmed. 28262800 2017
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The patients with coexisting T1D and CeD had an intermediate carrier frequency (72.8%) of the DRB1 *03:01- DQB1 *02:01- DQA1 *05:01 haplotype compared to T1D (64.1%) and CeD (88.7%) patients. 28247576 2017
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Among the strongest T1D HLA associations, stands out, as susceptible, the alleles DRB1*04:05 (OR = 7.3), DQB1*03:02 (OR = 6.1) and DQA1*03:03 (OR = 4.5), as well as the haplotypes DRB1*04:05-DQA1*03:03-DQB1*03:02 (OR = 100.9) and DRB1*04:04-DQA1*03:01-DQB1*03:02 (OR = 22.1), and DQB1*06:02 (OR = 0.07) and DRB1*15:01-DQA1*01:02-DQB1*06:02 (OR = 0.04) as protective. 28834219 2017
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE We studied helper T-lymphocyte reactivity against β-cell autoantigens by measuring production of the pro-inflammatory cytokine interferon-γ and the anti-inflammatory cytokine interleukin-10, using enzyme-linked immunospot assays in 61 people with Type 1 diabetes (within 3 months of diagnosis, positive for HLA DRB1*0301 and/or *0401), of whom 33 were children/adolescents, and a further 91 were unaffected siblings. 27151105 2017
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE These data suggest DRB1*08:02-DQB1*03:02 to be a contributing factor for familial clustering of type 1 diabetes in this family. 28107781 2017
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Besides the well recognized association of HLA-DRB1 and DQB1 alleles with type 1 diabetes mellitus (T1D), linkage studies have identified a gene region close to the non-classical class I HLA-G gene as an independent susceptibility marker. 26883941 2016
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE HLA-DRB1*03 as a risk factor for microalbuminuria in same duration of type 1 diabetes: a case control study. 27036319 2016
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE DRB1*04:01 and *04:02 were also predisposing for T1D in Arabs. 26818122 2016
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Moreover, the relatives with DRB1*15:01-DQA1*01:02-DQB1*06:02 less frequently expressed autoantibodies associated with higher T1D risk, were less likely to have multiple autoantibodies at baseline, and rarely converted from single to multiple autoantibody positivity on follow-up. 26822082 2016
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE We also confirm that genetic susceptibility to T1D is associated with the DRB1*03:01-DQA1*05:01-DQB1*02:01 and DRB1*04-DQA1*03:01-DQB1*03:02 haplotypes in Brazilian northeast region. 26492519 2016
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE The summary effect of haplotypes was generally seen in genotypes, while the expected synergistic effect of DR3-DQ2 and DR4-DQ8 (DRB1*04:03 excluded) combination was also clear in the T1D risk association analysis. 27411431 2016
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The NIR-SPIDDM group had lower frequency of susceptible HLA-DRB1*04:05-DQB1*04:01 and a higher frequency of resistant HLA-DRB1*15:01-DQB1*06:02 haplotype compared to IR-SPIDDM. 27177031 2016
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE To illustrate this methodology, we apply it to a T1D study with eight HLA genes (HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQA1, HLA-DQB1, HLA-DPA1, and HLA-DPB1) to build a predictive model. 27080919 2016
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE DRB4*01:03:01 was strongly associated with type 1 diabetes (P = 10(-36)), yet its association was extensively affected by DRB1 alleles from protective (DRB1*04:03:01) to high (DRB1*04:01:01) risk, but its association with DRB1*04:05:01 decreased the risk. 26740600 2016
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The strongly associated T1D haplotype DRB1*0301-DQA1*05-DQB1*0201 is also associated with LADA but confers only half of the T1D risk (odds ratio 2.65 vs 4.84). 26866570 2016
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Haplotype analysis revealed that patients with T1D had higher frequencies of DRB1*03:01-DQB1*02:01 (OR = 4.86, P < 10(-7) ) and DRB1*04:02-DQB1*03:02 (OR = 9.93, P < 10(-7) ) and lower frequencies of DRB1*07:01-DQB1*02:01 (P = 0.0005), DRB1*11:01-DQB1*03:01 (P = 0.001), DRB1*13:01-DQB1*06:03 (P = 0.002) and DRB1*15-DQB1*06:01 (P = 0.001) haplotypes compared to healthy controls. 26088816 2015
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The frequency of DRB1*04:05-DQB1*04:01, a susceptible haplotype for type 1 diabetes, was significantly lower in patients with AA (TRAb-positive: 8.5%; TRAb-negative: 11.9%) than in those with type 1 diabetes (29.5%, Pc < .0003 and Pc < .0008, respectively). 25734250 2015
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Because of the strong association of T1D with DRB1*03:01 and DRB1*04:01, we stratified our analyses based on families whose probands were positive for DRB1*03:01 or DRB1*04:01. 26539552 2015
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The patient's GADAb titer was 6.9 U/mL (normal: <1.4 U/mL) and the patient had a type 1 diabetes susceptible HLA class II haplotype known in the Japanese population as: DRB1*04:05-DQB1*04:01. 26440526 2015
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE The association of HLA class II (DRB1*, DQB1*) in type 1 diabetes was analyzed in fifty-one Moroccan families, including 90 diabetics. 25555495 2015
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Linkage disequilibrium with HLA-DRB1-DQB1 haplotypes explains the association of TNF-308G>A variant with type 1 diabetes in a Brazilian cohort. 25965561 2015
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The DRB1*0401-DQ8 and DRB1*0404-DQ8 haplotypes were associated with T1D subjects positive for GAD65, IA-2, and ZnT8A. 26405067 2015