Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE Among the strongest T1D HLA associations, stands out, as susceptible, the alleles DRB1*04:05 (OR = 7.3), DQB1*03:02 (OR = 6.1) and DQA1*03:03 (OR = 4.5), as well as the haplotypes DRB1*04:05-DQA1*03:03-DQB1*03:02 (OR = 100.9) and DRB1*04:04-DQA1*03:01-DQB1*03:02 (OR = 22.1), and DQB1*06:02 (OR = 0.07) and DRB1*15:01-DQA1*01:02-DQB1*06:02 (OR = 0.04) as protective. 28834219 2018
Diabetes Mellitus, Insulin-Dependent
0.400 Biomarker disease BEFREE Combined effect of glutamine at position 70 of HLA-DRB1 and alanine at position 57 of HLA-DQB1 in type 1 diabetes: An epitope analysis. 29494662 2018
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE We also confirm that genetic susceptibility to T1D is associated with the DRB1*03:01-DQA1*05:01-DQB1*02:01 and DRB1*04-DQA1*03:01-DQB1*03:02 haplotypes in Brazilian northeast region. 26492519 2016
Diabetes Mellitus, Insulin-Dependent
0.400 Biomarker disease BEFREE HLA-DRB1*03 as a risk factor for microalbuminuria in same duration of type 1 diabetes: a case control study. 27036319 2016
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE Besides the well recognized association of HLA-DRB1 and DQB1 alleles with type 1 diabetes mellitus (T1D), linkage studies have identified a gene region close to the non-classical class I HLA-G gene as an independent susceptibility marker. 26883941 2016
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE The patient's GADAb titer was 6.9 U/mL (normal: <1.4 U/mL) and the patient had a type 1 diabetes susceptible HLA class II haplotype known in the Japanese population as: DRB1*04:05-DQB1*04:01. 26440526 2016
Diabetes Mellitus, Insulin-Dependent
0.400 Biomarker disease BEFREE To illustrate this methodology, we apply it to a T1D study with eight HLA genes (HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQA1, HLA-DQB1, HLA-DPA1, and HLA-DPB1) to build a predictive model. 27080919 2016
Diabetes Mellitus, Insulin-Dependent
0.400 Biomarker disease BEFREE The association of HLA class II (DRB1*, DQB1*) in type 1 diabetes was analyzed in fifty-one Moroccan families, including 90 diabetics. 25555495 2016
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE Haplotype analysis revealed that patients with T1D had higher frequencies of DRB1*03:01-DQB1*02:01 (OR = 4.86, P < 10(-7) ) and DRB1*04:02-DQB1*03:02 (OR = 9.93, P < 10(-7) ) and lower frequencies of DRB1*07:01-DQB1*02:01 (P = 0.0005), DRB1*11:01-DQB1*03:01 (P = 0.001), DRB1*13:01-DQB1*06:03 (P = 0.002) and DRB1*15-DQB1*06:01 (P = 0.001) haplotypes compared to healthy controls. 26088816 2016
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE Because of the strong association of T1D with DRB1*03:01 and DRB1*04:01, we stratified our analyses based on families whose probands were positive for DRB1*03:01 or DRB1*04:01. 26539552 2016
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE The profile of HLA-DRB1 alleles in Arabs with type 1 diabetes; meta-analyses. 26818122 2016
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE The DRB1*0404-DQ8 haplotype was also associated with T1D subjects whose sera recognized both polymorphic variants of zinc transporter 8, an effect not seen for DRB1*0401-DQ8. 26405067 2016
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE DRB4*01:03:01 was strongly associated with type 1 diabetes (P = 10(-36)), yet its association was extensively affected by DRB1 alleles from protective (DRB1*04:03:01) to high (DRB1*04:01:01) risk, but its association with DRB1*04:05:01 decreased the risk. 26740600 2016
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE Linkage disequilibrium with HLA-DRB1-DQB1 haplotypes explains the association of TNF-308G>A variant with type 1 diabetes in a Brazilian cohort. 25965561 2015
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE Risk genes and autoantibodies in Egyptian children with type 1 diabetes - low frequency of autoantibodies in carriers of the HLA-DRB1*04:05-DQA1*03-DQB1*02 risk haplotype. 25256132 2015
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE The frequency of DRB1*04:05-DQB1*04:01, a susceptible haplotype for type 1 diabetes, was significantly lower in patients with AA (TRAb-positive: 8.5%; TRAb-negative: 11.9%) than in those with type 1 diabetes (29.5%, Pc < .0003 and Pc < .0008, respectively). 25734250 2015
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE DRB1 and DQB1 allele frequencies were similar for both A(-) KPD and T2D patients; they did not confer any substantial risk even after considering type 1 diabetes susceptibility and resistance alleles. 25511714 2015
Diabetes Mellitus, Insulin-Dependent
0.400 Biomarker disease CTD_human Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk. 26168013 2015
Diabetes Mellitus, Insulin-Dependent
0.400 Biomarker disease BEFREE Interestingly, HLA-DRB1*09:01 has been shown to be associated with multiple autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus, suggesting that either HLA-DRB1*09:01 itself or other genes in tight linkage disequilibrium may play a role in a molecular pathway shared by various autoimmune diseases in Japanese and possibly in other Asian populations. 23180035 2014
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE HLA-DRB, -DQA, and DQB alleles and haplotypes in Iranian patients with diabetes mellitus type I. 22583516 2014
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE We proved that INS and PTPN22 genes marginally influence T1D risk in all risk HLA-DRB1 genotype categories. 24260237 2014
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE Dividing the APS collective into those with Addison's disease (APS type II) and those without Addison's disease but including type 1 diabetes and AITD (APS type III) demonstrated DR3-DQ2/DRB1*04:01-DQ8 as a susceptibility genotype in APS III (Pc<.001), whereas the DR3-DQ2/DRB1*04:04-DQ8 genotype correlated with APS II (Pc<.001). 24187405 2014
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE The HLA-B*39 allele increases type 1 diabetes risk conferred by HLA-DRB1*04:04-DQB1*03:02 and HLA-DRB1*08-DQB1*04 class II haplotypes. 24055898 2014
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE To assess the contribution of the HLA class II region for susceptibility to type 1 diabetes mellitus (T1DM), we investigated the association of HLA class II alleles-DP, DQ, and DRB1. 23121162 2013
Diabetes Mellitus, Insulin-Dependent
0.400 GeneticVariation disease BEFREE Haplotype analysis demonstrated that HLA-DRB1(Lys71+) allele provided major susceptibility for T1D, and DQβ1(Asp57-) had an additive effect. 22494469 2013