Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 GeneticVariation disease GWASCAT Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic. 24204295 2013
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 GeneticVariation disease BEFREE Thirty-four of the 54 children were HLA-typed, and they were all positive for narcolepsy risk allele DQB1*0602/DRB1*15. 22470463 2012
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 Biomarker disease BEFREE These results illustrate the extraordinary conservation of HLA class II effects in narcolepsy across populations and show that DRB1*15:01 has no effect on narcolepsy susceptibility in the absence of DQB1*06:02. 22862152 2012
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 Biomarker disease CTD_human To further define the genetic basis of narcolepsy risk, we performed a genome-wide association study (GWAS) in 562 European individuals with narcolepsy (cases) and 702 ethnically matched controls, with independent replication in 370 cases and 495 controls, all heterozygous for DRB1*1501-DQB1*0602. 20711174 2010
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 GeneticVariation disease BEFREE To further define the genetic basis of narcolepsy risk, we performed a genome-wide association study (GWAS) in 562 European individuals with narcolepsy (cases) and 702 ethnically matched controls, with independent replication in 370 cases and 495 controls, all heterozygous for DRB1*1501-DQB1*0602. 20711174 2010
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 SusceptibilityMutation disease ORPHANET Comparison of clinical characteristics among narcolepsy with and without cataplexy and idiopathic hypersomnia without long sleep time, focusing on HLA-DRB1( *)1501/DQB1( *)0602 finding. 19410508 2009
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 GeneticVariation disease GWASDB Genome-wide association database developed in the Japanese Integrated Database Project. 19629137 2009
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 GeneticVariation disease BEFREE The susceptibility alleles found in Mexicans with narcolepsy are also present in Japanese and Caucasians; DRB1*04 linked protection has also been shown in Koreans. 18706091 2008
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 SusceptibilityMutation disease ORPHANET The susceptibility alleles found in Mexicans with narcolepsy are also present in Japanese and Caucasians; DRB1*04 linked protection has also been shown in Koreans. 18706091 2008
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 GeneticVariation disease LHGDN We examined DRB1, DRB3, DRB4, DRB5, DQA1, and DQB1 in 163 patients with centrally mediated daytime sleepiness (100 with narcolepsy) and 211 Korean controls. 17207713 2007
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 GeneticVariation disease BEFREE HLA-DQB1*0602 and HLA DRB1 alleles are closely associated with narcolepsy. 18345414 2007
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 Biomarker disease BEFREE Complementary approaches were used to investigate residual predisposing effects of microsatellite alleles comprising the extended DRB1*15 haplotype taking into account the strong predisposing effect of DRB1*15: (1) Disease association of the extended DRB1*15 haplotype was compared for MS and narcolepsy families--predisposing effects were observed for extended class I microsatellite marker alleles in MS families, but not narcolepsy families; (2) disease association of the extended DRB1*15 haplotype was investigated after conditioning MS and control haplotypes on the absence of DRB1*15--a significant predisposing effect was observed for a 627-kb haplotype (D6S258 allele 8-MOGCA allele 4; MOG, myelin oligodendrocyte glycoprotein) spanning the extended class I region. 17256150 2007
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 GeneticVariation disease LHGDN HLA-DQB1 genotyping in a family with narcolepsy-cataplexy. 17658488 2007
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 GeneticVariation disease BEFREE One genetic factor strongly associated with narcolepsy is the HLA-DRB1*1501-DQB1*0602 haplotype in the human leukocyte antigen region on chromosome 6, whereas the other genetic factors are not clear. 16826516 2006
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 GeneticVariation disease BEFREE Several DRB1 (*0101, *0405, *0901) and DQB1 alleles (*0303, *0401, *0501, *0601, *0604) were found to have weak protective effects against narcolepsy. 17002906 2006
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 Biomarker disease LHGDN The authors demonstrated that DRB1 1501 and DQB1 0602 were susceptibility genes for narcolepsy and those who were DRB1 15 negative could not be excluded. 15157381 2004
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 GeneticVariation disease BEFREE The T-allele of the C-857T polymorphism was strongly associated with narcolepsy in the subgroup of DRB1*15/16 (HLA-DR2 type) negative patients, but not in DRB1*15/16 positive patients. 12823767 2003
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 Biomarker disease BEFREE There is no detailed report of HLA-DRB1*1501/DQB1*0602 positive monozygotic twins concordant for narcolepsy, with marked difference in the age of onset. 11377412 2001
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 GeneticVariation disease BEFREE In previous studies, we suggested that the tumor necrosis factor (TNF-alpha and its receptor 2 (TNFR2) genes could be associated with the susceptibility to human narcolepsy, and that haplotype carrying DRB1*1502 had a negative association with the disorder. 11285131 2001
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 Biomarker disease BEFREE Although narcolepsy is highly associated with human leukocyte antigen (HLA) DQ6/DQB1*0602 and/or DR2/DRB1*1501, most individuals with the HLA haplotype are free of narcolepsy. 10777671 2000
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 GeneticVariation disease BEFREE A genetic factor strongly associated with the disorder has been found in the human leukocyte antigen (HLA) class II region: the haplotype, DRB1*1501-DQB1*0602, predisposes to narcolepsy. 10488740 1999
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 GeneticVariation disease BEFREE The haplotype DRB1*1501-DRB5*0101-DQA1*0102-DQB1*0602 was found to be significantly associated with the disease, while the haplotype DRB1*0701-DRB4*01-DQA1*0201-DQB1*02 might confer a slight protective effect against narcolepsy. 9534039 1997
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 Biomarker disease BEFREE DQB1*0602 was found to be a more sensitive marker for narcolepsy than DRB1*15 across all ethnic groups. 9456467 1997
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 Biomarker disease BEFREE In Black Americans, however, DRB1*1501 (DR2) was a poor marker for narcolepsy. 7701202 1994
CUI: C0027404
Disease: Narcolepsy
Narcolepsy
0.700 GeneticVariation disease BEFREE A deletion in the second exon of an HLA-DRB1 allele found in a DR2-negative narcolepsy patient. 7980729 1993