Neuralgia
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, we found that miR-129-5p alleviated neuropathic pain through downregulating high mobility group protein B1 (HMGB1) expression in CCI rats as overexpression of miR-129-5p suppressed expression of both HMGB1 and proinflammatory cytokine and alleviated pain sensation in CCI rats.
|
31489582 |
2020 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The current study aimed to characterize neuropathic pain-induced changes in affect over time and to determine whether HMGB1 has a role in neuropathic pain-induced changes in affect.
|
30763674 |
2019 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Since there is growing evidence that spinal MIF and HMGB1 mediate inflammatory and neuropathic pain we examined whether there were spinal changes occurring during persistent bladder pain that may be responsible for maintaining bladder pain.
|
30708129 |
2019 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We aim to explore whether 2Hz EA stimulation regulates the spinal HMGB1/NF-κB signaling in neuropathic pain induced by spared nerve injury (SNI).
|
31695479 |
2019 |
Neuralgia
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
This study aimed to explore the role of microRNA (miR)-193a in diabetic neuropathic pain through the regulation of HMGB1.
|
31665716 |
2019 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
By contrast, the cellular mechanism by which spinal HMGB1 induces neuropathic pain has yet to be fully elaborated.
|
31273787 |
2019 |
Neuralgia
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Downregulation of HMGB1 can inhibit neuropathic pain behaviors which can be reversed by miR-381 inhibitors.
|
29633273 |
2018 |
Neuralgia
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Sigma 1 receptor mediated HMGB1 expression in spinal cord is involved in the development of diabetic neuropathic pain.
|
29421543 |
2018 |
Neuralgia
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Overall, these results suggest that miR‑142‑3p functions as a negative regulator of neuropathic pain development through the downregulation of HMGB1, indicating that miR‑142‑3p may serve as a potential therapeutic target for neuropathic pain.
|
29115575 |
2018 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
High mobility group box 1 protein (HMGB1) and Chemokine CXC receptor 4 (CXCR4) participate in neuropathic pain development.
|
30142543 |
2018 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Then we review studies that address HMGB1 as a potential therapeutic target for NPP.
|
27294160 |
2016 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Though it is known that dorsal root ganglia (DRG) sensory neurons exposed to HMGB1 and TLR4 agonists can influence excitation, the degree to which at-HMGB1 signaling through neuronal RAGE contributes to neuropathic pain is unknown.
|
25014009 |
2014 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Here, we overview the characteristics of HMGB1 as a pro-inflammatory mediator and show the promise of HMGB1 as a therapeutic target for neuropathic pain.
|
24285082 |
2013 |