HMGB1, high mobility group box 1, 3146

N. diseases: 724; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE In this study, we focused on plasma samples from 2 patients who survived sepsis and exhibited high titer antibodies to HMGB1. 31767118 2020
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Intranuclear proteins, including high mobility group box 1 (HMGB1) and histone H3, released from inflammatory cells activate platelets and the coagulation systems, leading to development of disseminated intravascular coagulation (DIC) in individuals with sepsis. 31848990 2020
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE Moreover, a significant upregulation of gene and protein expressions of HMGB1 and its related TLR4 and NF-κB were observed in the MI group when compared with the sham group. 31280453 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE High-dose intramyocardial HMGB1 induces long-term cardioprotection in sheep with myocardial infarction. 30859393 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE TLR9 is essential for HMGB1-mediated post-myocardial infarction tissue repair through affecting apoptosis, cardiac healing, and angiogenesis. 31209243 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE High mobility group box-1 in hypothalamic paraventricular nuclei attenuates sympathetic tone in rats at post-myocardial infarction. 30338842 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 AlteredExpression disease BEFREE These data reveal that H<sub>2</sub> gas could suppress lung injury in septic mice through regulation of HO-1 and HMGB1 expression and that Nrf2 plays a main role in the protective effects of H<sub>2</sub> gas on lung damage caused by sepsis. 30660872 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE High Mobility Group Box-1 (HMGB1) is a non-histone nuclear protein that has been implicated in many pathological processes, from sepsis to ischemia. 31835864 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE HMGB-1 is considered as an essential facilitator in diseases such as sepsis, collagen disease, atherosclerosis, cancers, arthritis, acute lung injury, epilepsy, myocardial infarction, and local and systemic inflammation. 31215389 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE The pooled mean differences in biomarker concentration (nonsurvivors - survivors), measured at onset of sepsis, are listed as follows: (1) Ang-1: - 2.9 ng/ml (95% CI - 4.1 to - 1.7, p < 0.01); (2) Ang-2: 4.9 ng/ml (95% CI 2.6 to 7.1, p < 0.01); (3) HMGB1: 1.2 ng/ml (95% CI 0.0 to 2.4, p = 0.05); (4) sRAGE: 1003 pg/ml (95% CI 628 to 1377, p < 0.01); (5) sTREM-1: 87 pg/ml (95% CI 2 to 171, p = 0.04); (6) suPAR: 5.2 ng/ml (95% CI 4.5 to 6.0, p < 0.01). 31705327 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE The purpose of this study was to quantify measures of endothelial function, including markers of activation (endocan, Angiopoietin-2 [Ang-2], and von Willebrand Factor), endogenous anticoagulants (tissue factor pathway inhibitor and protein C), and damage-associated factors (High Mobility Group Box 1 [HMGB-1]) in the plasma of patients with sepsis and DIC, and to determine the relationship of these factors with severity of illness and outcome. 31140293 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE High mobility group box 1 (HMGB1) is a proinflammatory cytokine associated with death from sepsis and other inflammatory diseases. 30780033 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE These data suggest that central HMGB1 might be a potential therapeutic target for septic challenge and that inhibition of brain HMGB1 can protect against multiple organ dysfunction induced by sepsis. 30881224 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE This review highlights some of the mechanisms that contribute to location and functions of HMGB1, and focuses on some recent insights on important intracellular effects of HMGB1 during sepsis and trauma. 30946496 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Quercetin Exerted Protective Effects in a Rat Model of Sepsis via Inhibition of Reactive Oxygen Species (ROS) and Downregulation of High Mobility Group Box 1 (HMGB1) Protein Expression. 31377749 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE The expression of α7nAChR, toll-like receptor 4 (TLR4), high mobility group box 1 (HMGB1), and cleaved caspase-3 increased, peaking 24 h during sepsis. 31520992 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE We explored the effect and mechanism of SIRT1 on HMGB1 using a mouse model of cecal ligation and puncture-induced sepsis and LPS-treated human kidney (HK-2) cell line. 30379096 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Rare ginsenosides, Rk1 (SB1) and Rg5 (SB2), are among the main components of black ginseng and are prepared from ginsenoside Rd by steaming at 120 °C for 3 h. We examined the effects of SB1 and SB2 on HMGB1-mediated septic response and survival rate in a mouse model of sepsis. 30496780 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE This study investigated the mechanism by which sLPC inhibits lipopolysaccharide (LPS)-induced extracellular secretion of HMGB1 after the onset of sepsis. sLPC increased AMPK phosphorylation and the binding of AMPK to calcium/calmodulin-dependent protein kinase kinase β (CaMKKβ), one of the upstream signals of AMPK. 30797785 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Taken together, the present results suggest that KC1 and KC3 both reduced HMGB1 release and septic mortality and, thus, may be useful for the treatment of sepsis. 30822402 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE The NLR family pyrin domain-containing 3 (NLRP3) inflammasome is a multimeric protein complex that mediates maturation of the cytokines IL-1β and IL-18 as well as release of the proinflammatory protein high-mobility group box 1 (HMGB1) and contributes to several inflammatory diseases, including sepsis, gout, and type 2 diabetes. 30971430 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 AlteredExpression disease BEFREE The expression levels of HMGB-1 and TF of the rats with sepsis gradually increased with time, and the level of HMGB-1 was positively correlated with the level of TF. 30840287 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE High mobility group box chromosomal protein-1 (HMGB-1) is a potential late mediator of sepsis and a possible risk factor for postoperative pulmonary complications after esophagectomy. 31498489 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE The HMGB1 gene rs2249825 and rs1045411 site SNPs were associated with sepsis risk, but the rs1360485 site SNP was not associated with sepsis risk. 30423384 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE High mobility group box-1 protein (HMGB1) is a late inflammatory mediator associated with sepsis, malignancy, and immune disease. 30853709 2019