Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Recently, we and others examined blood HO-1 levels in patients with atherosclerotic diseases, e.g., coronary artery disease (CAD) and peripheral artery disease (PAD).
|
31344980 |
2019 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found that MDMs of healthy subjects exhibited a lower oxidative stress status, lower Nrf2 and HO-1 levels as compared to CAD patients.
|
30995787 |
2019 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
After excluding the 36 patients with PAD, HO-1 levels were significantly higher in 192 patients with CAD than in 182 without CAD (0.45 versus 0.35 ng/mL, <i>P</i> < 0.05).
|
30159103 |
2018 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Nonetheless, rs2071746 in HO-1 was found to be only associated with perimenopausal CAD risk (OR: 0.67, 95% CI: 0.58-0.78, P < 0.05).
|
28444966 |
2017 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Heme oxygenase-1 gene promoter polymorphisms are associated with coronary heart disease and restenosis after percutaneous coronary intervention: a meta-analysis.
|
27825138 |
2016 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Overall, no significantly decreased risk of CAD was found in persons with the SS genotype of the HO-1 (GT)n repeat length polymorphism compared with those with the LL + SL genotype.
|
24670375 |
2014 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study screened for HMOX1 polymorphisms and investigated the association between HMOX1 polymorphisms and coronary artery disease (CAD) in the Korean population.
|
25187885 |
2014 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the allelic frequencies of guanosine thymidine dinucleotide repeats in the heme oxygenase-1 gene promoter in 386 patients with coronary artery disease recruited from January 1999 to July 2001 and followed until August 31, 2012.
|
24762402 |
2014 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The allele frequency of the HO-1 gene promoter (GT)n repeats was examined in CAD patients with de novo lesions (n = 328).
|
23602216 |
2013 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The prediction of coronary artery disease based on non-invasive examinations and heme oxygenase 1 polymorphism versus virtual histology.
|
23293173 |
2013 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Short (GT) ( n ) repeats in heme oxygenase-1 gene promoter are associated with lower risk of coronary heart disease in subjects with high levels of oxidative stress.
|
22120665 |
2012 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although a direct association between HO-1, vulnerable plaque development, and clinical outcome is for now missing, the correlations that have been reported for HO-1 and coronary artery disease point to a possible link.
|
20656217 |
2010 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional GT-repeat polymorphism in the HO-1 gene promoter was inversely correlated to the development of coronary artery disease in diabetics and development of restenosis following angioplasty in patients.
|
20796278 |
2010 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional GT-repeat polymorphism in the heme oxygenase-1 (HO-1) gene promoter is inversely correlated with the development of coronary artery disease and restenosis after clinical angioplasty.
|
20708634 |
2010 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We aimed to examine whether the length of (GT)(n) repeats in HO-1 gene promoter is associated with ischemic stroke in people with CAD risk factors, especially low level of HDL.
|
20175935 |
2010 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A (GT)n dinucleotide repeat and a -413A>T single nucleotide polymorphism have been reported in the promoter region of HMOX1 to both influence the occurrence of coronary artery disease and myocardial infarction.
|
19389234 |
2009 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The protein expression of heme oxygenase-1, hypoxia inducible factor-1alpha, and ubiquitin was significantly stronger in patients with coronary heart disease than in controls, and the expression levels increased with the severity of the disease.
|
19676145 |
2009 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
With adjustment for both serum bilirubin and ferritin, the effect of HO-1 promoter polymorphism on susceptibility to CAD disappeared.
|
18443197 |
2008 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
With adjustment for both serum bilirubin and ferritin, the effect of HO-1 promoter polymorphism on susceptibility to CAD disappeared.
|
18443197 |
2008 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Reduced expression of heme oxygenase-1 in patients with coronary atherosclerosis.
|
17541213 |
2007 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The HO-1 gene GT dinucleotide repeat promoter polymorphism and HO-1 +99G/C variant were evaluated in 199 patients with coronary artery disease after coronary stent implantation and control angiography at 6 months after the intervention.
|
16020495 |
2005 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although potentially beneficial effects of the short HO-1 allele on lipid profile and serum bilirubin were observed, in contrast to Orientals, the HO-1 genotype was not associated with coronary artery disease in Caucasians.
|
14691581 |
2004 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Intragraft heme oxygenase-1 and coronary artery disease after heart transplantation.
|
15589739 |
2004 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Length polymorphism in the HO-1 gene promoter is related to CAD susceptibility in Japanese people who also have coronary risk factors such as hypercholesterolemia, diabetes, and smoking.
|
12377749 |
2002 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To test the association of microsatellite polymorphism in the promoter region of human HO-1 gene with the risk of coronary artery disease (CAD) in type 2 diabetic patients, we examined the allele frequencies of (GT) (n) repeats in HO-1 gene in 474 patients with CAD and in 322 controls.
|
12136229 |
2002 |