Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the adenomatous polyposis coli (APC) gene initiate the majority of both sporadic and hereditary colorectal cancers (CRC) and around 30% of these mutations are nonsense mutations.
|
31283021 |
2020 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
APC gene pathogenic variants are characterized by a lifetime risk of nearly 100% to develop a colorectal carcinoma.
|
31802619 |
2020 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Colorectal cancer (CRC) development is characterized by the stepwise accumulation of mutations over time, of which mutations in the tumor suppressor APC are often very early to occur.
|
30799131 |
2020 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
IMPLICATIONS: The tumor-suppressive function of APC, the most frequently mutated gene in colorectal cancer, is mainly attributed to its role in β-catenin/Wnt signaling.
|
31160382 |
2019 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Colorectal cancers (CRCs) initiate through distinct mutations, including in APC pathway components leading to tubular adenomas (TAs); in BRAF, with epigenetic silencing of CDX2, leading to serrated adenomas (SAs); and in the DNA mismatch repair machinery driving microsatellite instability (MSI).
|
30716341 |
2019 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
One of the major characteristics of CRC is enhanced Wnt signaling caused by loss-of-function mutations in the adenomatous polyposis coli (APC) gene.
|
30867802 |
2019 |
Colorectal Carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
WNT signaling activation in colorectal cancers (CRCs) occurs through APC inactivation or β-catenin mutations.
|
31804558 |
2019 |
Colorectal Carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
We also discuss the diagnostic and prognostic value of the APC gene in the pathogenesis of CRC for a better understanding of CRC disease.
|
30414835 |
2019 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
PET/CT-derived radiomics can provide supplemental information to determine KRAS, TP53, and APC genetic alterations in CRC.
|
29948642 |
2019 |
Colorectal Carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
The adenomatous polyposis coli (APC) gene plays a pivotal role in the pathogenesis of colorectal carcinoma (CRC) but remains a challenge for drug development.
|
30511962 |
2019 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
After filtering, 15 pathogenic germline variants (9.9%) were found in 15 patients, arising from 9 genes of varying penetrance for colorectal cancer (APC (n = 2; 13%), ATM (n = 1; 6%), BRCA1 (n = 2; 13%), CDH1 (n = 2; 13%), CHEK2 (n = 4; 27%), MSH2 (n = 1; 7%), MSH6 (n = 1; 7%), NF2 (n = 1; 7%), and TP53 (n = 1; 7%)).
|
30730459 |
2019 |
Colorectal Carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
To further investigate the role of Wntless in tumorigenesis, APC-deficient spontaneous intestinal tumors and chemical induced colorectal cancer mouse models were employed.
|
31547988 |
2019 |
Colorectal Carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
The remaining case was CIMP negative and MMR proficient in both the components, harbored a BRAF mutation in the SSA/P counterpart, whereas the CRC one was APC and TP53 mutated and showed p16 and β-catenin dysregulation.
|
30738693 |
2019 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Genetic factors such as germline MLH1 and APC mutations have an aetiologic role, predisposing individuals to CRC.
|
31455888 |
2019 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The classical genetic model of colorectal cancer presents APC mutations as the earliest genomic alterations, followed by KRAS and TP53 mutations.
|
31416464 |
2019 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Truncating mutations of APC generated by CRISPR/Cas9 strongly synergize with MEK inhibitors in enhancing Wnt responses in isogenic CRC models.
|
31097693 |
2019 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110).
|
31485167 |
2019 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The adenomatous polyposis coli (APC) gene is mutated within specific sequence contexts in colorectal carcinomas but the underlying mechanism is not fully understood.
|
31732732 |
2019 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
GWASCAT |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Inactivation of the Adenomatous polyposis coli (APC) gene is an initiating and the most relevant event in most sporadic cases of colorectal cancer, providing a rationale for using Apc-mutant mice as the disease model.
|
30637899 |
2019 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The adenomatous polyposis coli (APC) gene is mutated in familial adenomatous polyposis and in the majority of sporadic CRCs.
|
31414579 |
2019 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Colorectal cancer is a complex disease driven by well-established mutations such as APC and other yet to be identified pathways.
|
31213502 |
2019 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
To obtain new insights into the mechanisms underlying APC mutation and to elucidate the mechanisms of CRC development, we performed to identify the potential metabolites in FAP based on metabolomic strategy.
|
30983515 |
2019 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We also identified apoptosis-related genes enriched with ancestor mutations in lung cancers and a relationship between APC hotspot mutations and TP53 mutations in colorectal cancers.
|
29697365 |
2018 |
Colorectal Carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
The wnt/APC/<i>β</i>-catenin pathway is a critical initiator in colorectal carcinogenesis in both hereditary and sporadic colorectal cancer (CRC).
|
30186819 |
2018 |