Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The selective ERα antagonist could significantly decrease Wnt2b/LRP8/Dvl1 expression, increase destruction complex (Axin2/GSK3a/APC) expression, and promote degradation of β-catenin in colon carcinoma cell by inhibited NLRP3 expression.
|
31121307 |
2019 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Heme induces multiple genetic alterations by regulating WNT signalling pathway and causing mutations in major colon cancer genes such as APC, TP53 and KRAS.
|
29759553 |
2018 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Protein interactions of FAM134B with EB1 and APC/beta-catenin in vitro in colon carcinoma.
|
29964340 |
2018 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Carriers with mutations in the APC gene develop polyps in the colon and rectum which if not managed, transition into colon cancer.
|
30256815 |
2018 |
Colon Carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The correlation between the methylation of APC gene and pathological parameters of colon cancer patients was analyzed.
|
28781669 |
2017 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to assess whether chronic infection with T. muris does indeed influence the development of cancer hallmarks, both wild type mice and colon cancer model (APC min/+) mice were infected with this parasite.
|
28650985 |
2017 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APC gene mutations have been associated to have a role in colon cancer and since gastric and colon tumors share some common genetic lesions, it is relevant to investigate the role of APC tumor suppressor gene in gastric cancer.
|
28576136 |
2017 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The effect of doxorubicin and flavonoid extract on colon cancer HT-29 cell line death and identification of APC gene expression and PARP concentration of HT-29 cell line were investigated.
|
27064876 |
2016 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We initially validated that INSIG2 is a gene with univariate-negative prognostic capacity to discriminate human colon cancer survivorship and that if present along with adenomatous polyposis coli (APC) gene mutations further decrease overall survival.
|
26662938 |
2016 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer.
|
26305864 |
2015 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
HGUE-C-1 represents a novel and peculiar colon carcinoma model to study chemoresistance to chemotherapeutic agents and to novel anti-neoplasic drugs that interrupt signalling pathways such as the APC/βcatenin, Ras/Raf/Mek/Erk, PI3K/mTOR/p70S6K pathways as well as histone regulation mechanisms.
|
25885658 |
2015 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using mass spectrometry-based metabolomics, the current study revealed the accumulation of four uremic toxins (cresol sulfate, cresol glucuronide, indoxyl sulfate, and phenyl sulfate) in the serum of mice harboring adenomatous polyposis coli (APC) gene mutation-induced colon cancer.
|
25712450 |
2015 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in APC or CTNNB1 are highly frequent in colon cancer and cause aberrant stabilization of CTNNB1, which activates the transcription of Wnt target genes by binding to chromatin via the TCF/LEF transcription factors.
|
24651522 |
2014 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Truncating mutations of the APC gene result in the constitutive stabilisation of β-catenin and the initiation of colon cancer, although tumour cells tolerate the expression of wild-type APCL.
|
24722208 |
2014 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we report a de novo germline mutation of APC as the causal variant in a Chinese family with inheritable colon cancer by the next generation sequencing.
|
24735542 |
2014 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Truncating mutations affect the adenomatous polyposis coli (APC) gene in most cases of colon cancer, resulting in the stabilization of β-catenin and uncontrolled cell proliferation.
|
23840886 |
2013 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ethanol-induced mast cell-mediated inflammation leads to increased susceptibility of intestinal tumorigenesis in the APC Δ468 min mouse model of colon cancer.
|
23320800 |
2013 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We reported that berberine significantly inhibited basal level and EGF-stimulated EGFR activation and proliferation in the immorto Min mouse colonic epithelial (IMCE) cells carrying the APC(min) mutation and human colonic carcinoma cell line, HT-29 cells.
|
23457600 |
2013 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In blinded specimens and colon cancer cell lines with defined mutations, ColoSeq correctly identified 28/28 (100%) pathogenic mutations in MLH1, MSH2, MSH6, PMS2, EPCAM, APC, and MUTYH, including single nucleotide variants (SNVs), small insertions and deletions, and large copy number variants.
|
22658618 |
2012 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention.
|
21885812 |
2011 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Somatic mutations of the APC gene have also been identified in the majority of sporadic colorectal carcinomas, and mutation of the APC gene appears to be an early step in the initiation of colon cancer.
|
21518821 |
2011 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Differential expression of microRNAs in tumors from chronically inflamed or genetic (APC(Min/+)) models of colon cancer.
|
21532750 |
2011 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Survivin-induced Aurora-B kinase activation: A mechanism by which APC mutations contribute to increased mitoses during colon cancer development.
|
21057000 |
2010 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We sought to create a transgenic mouse with Cre recombinase (Cre) expression limited to the epithelial cells of the large intestine and used this model to study colon cancer driven by adenomatosis polyposis coli (APC) gene inactivation.
|
20663863 |
2010 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
While germline mutations in the adenomatous polyposis coli (APC) gene cause the hereditary colon cancer syndrome (familial adenomatous polyposis (FAP)), the role of common germline APC variants in sporadic adenomatous polyposis remains unclear.
|
20510605 |
2010 |