|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The haptoglobin 2-2 genotype is associated with cardiac autonomic neuropathy in type 1 diabetes: the RETRO HDLc study.
|
31529337 |
2020 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Haptoglobin Phenotype Modulates Lipoprotein-Associated Risk for Preeclampsia in Women With Type 1 Diabetes.
|
31219590 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Hp genotypes have been associated with microvascular and macrovascular complications in type 1 diabetes mellitus but the association in type 2 diabetes is more consistent with cardiovascular complications.
|
29799294 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Proinflammatory cytokines and lipopolysaccharides were increased in type 1 diabetes, and gut permeability (determined by zonulin levels) was significantly increased in type 1 diabetes and MODY2.
|
30224347 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Some new biomarkers have been suggested for diagnosis of CD including ischemia-modified albumin (IMA), soluble syndecan-1 (SSDC-1), regenerating gene Iα (REG-Iα), Neurotensin, and Zonulin, which can be useful for diagnosis and screening of CD in childhood T1D.
|
30214462 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Haptoglobin(Hp) 2-2 genotype has been shown to increase coronary artery disease (CAD) risk in numerous type 2 diabetes studies but in only one type 1 diabetes cohort.
|
27539884 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Is Magnetic Resonance Imaging Detection of Kidney Iron Deposition Increased in Haptoglobin 2-2 Genotype Carriers with Type 1 Diabetes?
|
29298491 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Effect of vitamin E supplementation on HDL function by haptoglobin genotype in type 1 diabetes: results from the HapE randomized crossover pilot trial.
|
26002590 |
2016 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Individuals with type 1 diabetes and HP data available (n=486; mean baseline age, 27 and duration, 19 years) were selected for study.
|
26684170 |
2016 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that, although better control may reduce the incidence of coronary artery disease in Type 1 diabetes, a residual risk related to the haptoglobin 2 allele remains.
|
27028131 |
2016 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The haptoglobin 1 allele correlates with white matter hyperintensities in middle-aged adults with type 1 diabetes.
|
25213335 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Reported elevated IsoP and WBC count concentrations over time among Hp 2 allele carriers lead to the hypothesis that the antioxidative and anti-inflammatory capacity of the Hp 2 is inferior to that of the Hp 1 allele in type 1 diabetes.
|
26114833 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The prevalence of the 1/1, 2/1 and 2/2 Hp genotypes was 28.5%, 46.7% and 24.8% in patients with type 1 diabetes and 20.9%, 38.8% and 40.3% in controls, respectively.
|
26122942 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To study whether the 2-2 Hp genotype is associated with an increased risk of overt DN in a Spanish population with T1D.
|
24658196 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Despite the protective effect against vascular diabetes complications, a borderline increased risk of stroke was observed with Hp 1-1 in type 1 diabetes.
|
24994788 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent evidence suggests that the haptoglobin (HP) 2-2 genotype, which codes for a protein with reduced antioxidant activity, may predict renal function decline in type 1 diabetes.
|
23761102 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Haptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes.
|
22098782 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
RGD |
The identification and validation of haptoglobin as a putative serum biomarker for autoimmune T1D in rats now affords us the opportunity to test the validity of this protein as a biomarker for human T1D, particularly in those situations where viral infection is believed to precede the onset of disease.
|
20975081 |
2010 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Therapeutic
|
disease |
RGD |
Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat.
|
20853098 |
2010 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The association between Lp-PLA(2) activity and CAD differs by CRP and haptoglobin genotype in this group of persons with type 1 diabetes and macroalbuminuria.
|
20368232 |
2010 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
As oxidative stress has been associated with microvascular complications, we evaluated the relationship between Hp genotype and microalbuminuria, macroalbuminuria, end-stage renal disease (ESRD), and early renal function decline in type 1 diabetes.
|
19720796 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Hp genotypes of 265 patients, 95 type 1 diabetes mellitus (DM1) sufferers with at least 10 years of disease and 170 type 2 diabetes mellitus (DM2) sufferers with at least 5 years of disease were determined by allele-specific PCR; both groups included patients with and without DN.
|
19455468 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association between the haptoglobin genotype and the incidence of coronary artery disease (CAD) in a cohort of individuals with childhood-onset type 1 diabetes.
|
18332093 |
2008 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To evaluate endothelial function in adolescents with type 1 diabetes before the development of complications and to test for potential relationships between endothelial dysfunction and haptoglobin genotype.
|
17939622 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
When tested in serum samples collected during the pre-type 1 diabetes phase, elevated serum zonulin was detected in 70% of subjects and preceded by 3.5 +/- 0.9 years the onset of the disease in those patients who went on to develop type 1 diabetes.
|
16644703 |
2006 |