HP, haptoglobin, 3240

N. diseases: 464; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Significantly, compared to non-diabetics, BVRA and PKCζ expression was low and haptoglobin was high in T2D patients leukocytes. 31065010 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE An Okinawan-based Nordic diet improves glucose and lipid metabolism in health and type 2 diabetes, in alignment with changes in the endocrine profile, whereas zonulin levels are elevated. 30936958 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Serum Hp levels in T2DM patients and non-DM subjects were 103.40 (72.46, 131.99) mg/dL and 100.20 (53.99, 140.66) mg/dL, respectively. 30634984 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Urine Haptoglobin/Creatinine Ratio Correlates with Tubular Injury Biomarkers and Severity of Albuminuria in Type 2 Diabetes Patients. 31505705 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE The genetic variant rs2000999 was not associated with diabetic macrovascular diseases but showed an association with metabolic traits and serum Hp levels in Chinese patients with type 2 diabetes. 30366827 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Our findings suggest that serum Hp levels may be used as a potential biomarker for the early diagnosis and monitoring of DKD in T2DM patients. 31545979 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE <b>Conclusions:</b> These results suggest that subjects with type 2 diabetes carrying the Hp 1-1 genotype may have higher susceptibility to depression in the context of white matter damage and frontal lobe atrophy. 30809196 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Author Correction: Genetic markers for urine haptoglobin is associated with decline in renal function in type 2 diabetes in East Asians. 30190539 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE When combined with the glycation level of lysine-141 of haptoglobin, diagnostic accuracy improved further for newly diagnosed (SN, 94%; SP 96%) and long-term controlled (SN, 85%; SP, 94%) T2DM patients (HbA1c: SN, 88%; SP, 96%). 29943387 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Haptoglobin(Hp) 2-2 genotype has been shown to increase coronary artery disease (CAD) risk in numerous type 2 diabetes studies but in only one type 1 diabetes cohort. 27539884 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE We investigated whether serum Hp has a causal effect on macroangiopathy via Mendelian randomization (MR) analysis with common variants of the Hp gene in Chinese patients with type 2 diabetes. 29338727 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Genetic markers for urine haptoglobin is associated with decline in renal function in type 2 diabetes in East Asians. 29572449 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE The Hp genotypes have been associated with microvascular and macrovascular complications in type 1 diabetes mellitus but the association in type 2 diabetes is more consistent with cardiovascular complications. 29799294 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Haptoglobin 1-1 Genotype Modulates the Association of Glycemic Control With Hippocampal Volume in Elderly Individuals With Type 2 Diabetes. 28860127 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE A positive correlation was observed between Zo and LPS in T2DM-CKD subjects. 28925931 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE To collectively evaluate the association between haptoglobin (Hp) gene variants and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). 28758129 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE The distribution of Hp2 allele was higher in T2DM subjects compared to nondiabetic controls and the HbA1c levels of T2DM subjects carrying at least one Hp2 allele tended to be higher than T2DM subjects with Hp 1-1. 28218436 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE The combination of glycated lysine-141 of haptoglobin (HP K141) and HbA<sub>1c</sub> provided a sensitivity of 94%, a specificity of 98%, and an accuracy of 96% to identify T2DM. 28360826 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Urine haptoglobin, which is specific for PDR, is a novel biomarker and complement to urine albumin for predicting kidney damage in patients with T2D. 27903615 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE The haptoglobin 2-2 genotype is associated with atherosclerosis in type 2 diabetes mellitus. 27190085 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Ethnicity/culture modulates the relationships of the haptoglobin (Hp) 1-1 phenotype with cognitive function in older individuals with type 2 diabetes. 26388309 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Haptoglobin genotype modulates the relationships of glycaemic control with cognitive function in elderly individuals with type 2 diabetes. 25628235 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE This study examined the association of HP genotypes with subclinical CVD, T2DM risk, and associated risk factors in a T2DM-enriched sample. 23399657 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Haptoglobin 1-1 genotype is associated with poorer cognitive functioning in the elderly with type 2 diabetes. 23990521 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE We studied the association of the Hp gene polymorphism with T2DM in 584 unrelated T2DM patients and 690 control subjects with normal glucose tolerance among northern Chinese. 22300541 2012