HP, haptoglobin, 3240

N. diseases: 464; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 AlteredExpression disease BEFREE While the immune profiles in the different schizophrenia phenotypes indicate the activation of the immune-inflammatory response system (IRS), there are simultaneous signs of CIRS activation, including increased levels of the IL-1 receptor antagonist (sIL-1RA), sIL-2R and tumor necrosis factor-α receptors, Th-2 and Treg phenotypes with increased IL-4 and IL-10 production, and increased levels of TRYCATs and haptoglobin, α2-macroglobulin, and other acute-phase reactants, which have immune-regulatory and anti-inflammatory effects. 31473906 2020
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 Biomarker disease BEFREE IgM responses to zonulin were positively associated with schizophrenia (versus controls), while IgM to occludin was significantly associated with deficit schizophrenia (versus non-deficit schizophrenia and controls). 30972627 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 Biomarker disease CTD_human Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. 18583979 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 Biomarker disease BEFREE Schizophrenia is accompanied by both an altered expression of Hp protein and a different genotype distribution of Hp gene, demonstrating that Hp is associated with schizophrenia. 16897611 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 AlteredExpression disease BEFREE Recently, it was shown that schizophrenia is accompanied by an activation of the inflammatory response system with signs of an acute phase response, such as increased plasma haptoglobin (Hp) concentrations. 11600184 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 Biomarker disease BEFREE Haptoglobin and transferrin types in schizophrenia. 3857216 1985