HRAS, HRas proto-oncogene, GTPase, 3265

N. diseases: 698; N. variants: 29
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma
0.450 GeneticVariation disease BEFREE Furthermore, the HRAS c.37G>C mutation has never been related to any type of rhabdomyosarcoma. 29430633 2018
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma
0.450 GeneticVariation disease BEFREE Our results of common HRAS mutations and composite gene signature with RMS and neuronal/neuroblastic elements suggest a closer genetic link of MEM to RMS rather than to MPNST. 26872011 2016
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma
0.450 GeneticVariation disease BEFREE The results demonstrate that tumor profiling in archival tissue samples is a useful tool for identifying diagnostic markers and potential therapeutic targets and suggests that these HRAS/ PIK3CA mutations play a critical role in the genesis of RMS. 24641407 2014
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma
0.450 GeneticVariation disease LHGDN Uniparental disomy at chromosome 11p15.5 followed by HRAS mutations in embryonal rhabdomyosarcoma: lessons from Costello syndrome. 17164262 2007
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma
0.450 GeneticVariation disease BEFREE To gain an understanding of the relationship between constitutional HRAS mutations and malignancy, HRAS was sequenced in an advanced biphasic rhabdomyosarcoma/fibrosarcoma from an individual with a 34G --> A mutation. 16372351 2006
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma
0.450 CausalMutation disease CGI
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma
0.450 Biomarker disease HPO