HRAS, HRas proto-oncogene, GTPase, 3265

N. diseases: 698; N. variants: 29
Disease: Thyroid carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.560 Biomarker disease BEFREE Tipifarnib Inhibits HRAS-Driven Dedifferentiated Thyroid Cancers. 29760048 2018
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.560 Biomarker disease BEFREE Some somatic oncogene mutations (BRAF, NRAS, HRAS, KRAS) as well as gene translocations (RET/PTC, PAX8/PPAR-gamma) have been associated with the development of thyroid cancer. 26259532 2016
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.560 GeneticVariation disease BEFREE Specific acquired RAS mutations have been found to predominate in different cancers, and HRAS T81C polymorphism has been determined to contribute the risk of various cancers, including thyroid cancer. 23150177 2013
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.560 GeneticVariation disease BEFREE We examined the activity of PLX4032 and PLX4720 in thyroid carcinoma cell lines harboring BRAF V600E (8505C, BCPAP, SW1736, BHT101), NRAS Q61R (HTH7), KRAS G12R (CAL62), HRAS G13R (C643), or RET/PTC1 (TPC-1) oncogenes. 19880792 2010
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.560 GeneticVariation disease BEFREE Variability of Ha-ras (codon 12) proto-oncogene mutations in diverse thyroid cancers. 9724079 1998
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.560 GeneticVariation disease BEFREE Thus the a4 and a2 alleles of c-Ha-ras-1 may perhaps be viewed as genetic markers of predisposition to lung, ovarian and thyroid cancer, respectively, in combination with other clinical parameters. 1980342 1990
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.560 Biomarker disease CTD_human Agent-specific ras oncogene activation in rat thyroid tumours. 3078959 1988
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.560 CausalMutation disease CGI