HRAS, HRas proto-oncogene, GTPase, 3265

N. diseases: 698; N. variants: 29
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 Biomarker disease BEFREE HRAS as a potential therapeutic target of salirasib RAS inhibitor in bladder cancer. 29901113 2018
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 Biomarker disease BEFREE This starts with the new GhrasT-NIH/Swiss cell line that was produced from the NIH/3T3 cell line that had been transformed by transfection with HRAS oncogene DNA from the T24 human bladder carcinoma. 26254261 2016
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 GeneticVariation disease BEFREE These results suggest that mosaicism for oncogenic HRAS mutations may increase the risk for developing BC at a young age. 24169525 2014
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 GeneticVariation disease CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 GeneticVariation disease BEFREE It is evident from our study that HRAS T81C SNP moderately increases bladder cancer risk, and rare allele is a predictive marker of advanced bladder tumors. 21514184 2013
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 AlteredExpression disease BEFREE Analysis of HRAS gene TRR methylation showed that the methylation level of HRAS has clinical relevance (P = 0.0049, by unpaired Student's t test) with bladder cancer. 22707223 2012
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 Biomarker disease BEFREE HRAS is a proto-oncogene involved in the tumorigenesis of urinary bladder cancer. 21931711 2011
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 GeneticVariation disease BEFREE All together, co-existence of Aurora-A overexpression and Ha-ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. 16338065 2006
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 GeneticVariation disease BEFREE HRAS1 genotype may be related to the prognosis of bladder cancer, however, because incident cases, i.e., newly diagnosed cases had a higher frequency of rare alleles than did prevalent cases, i.e., cases already existing at the time of recruitment. 12115522 2002
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 GeneticVariation disease BEFREE The observation that these cell lines have p53 and Ha-ras mutations identical to those in bladder carcinoma cell line T24 prompted us to investigate their possible interrelations. 11522622 2001
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 GeneticVariation disease BEFREE Furthermore, the bladder cancer cell lines were subjected to sequence analysis to identify a point mutation in the c-H-ras gene at codon 12. 10995035 2000
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 GeneticVariation disease BEFREE Cells of two human bladder carcinoma cell lines were used, one with a mutated oncogenic HRAS (T24) and other with a wild-type HRAS (RT4). 10856967 2000
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 AlteredExpression disease BEFREE The effects of 7-hydroxycoumarin, genistein and quercetin on two ras-oncogene-driven tumour cells (rat breast adenocarcinoma and human bladder carcinoma) were investigated using cellular (proliferation and migration) and molecular targets (p21ras GTPase activity and intracellular amount of p21ras protein). 8642043 1996
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 GeneticVariation disease BEFREE The c-Ha-ras-1 locus was studied by Southern blotting in white blood cells and tumor samples obtained from 126 patients with bladder cancer (74 Ta-T1 and 52 T2-T4). 8583569 1996
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 AlteredExpression disease BEFREE Lack of influence of c-Ha-ras expression on the drug sensitivity of human bladder cancer histocultured in three-dimensions. 8352563 1993
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 Biomarker disease BEFREE The induction of gene mutations and chromosome aberrations by plasmid pEJ6.6 carrying the activated c-Ha-ras-1 oncogene from human bladder carcinoma was studied in cultured Chinese hamster cells. 1521228 1992
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 AlteredExpression disease BEFREE Contrary to this, endogenous activated Ha-ras in a human bladder carcinoma cell line, T24, was not eliminated by BA. 1773788 1991
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 Biomarker disease BEFREE The non tumorigenic human mammary cell line HBL100 has been transformed by the EJ/T24 human bladder carcinoma Harvey(Ha)-ras oncogene. 1861862 1991
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 Biomarker disease BEFREE We showed previously that diploid human fibroblasts that express a transfected HRAS oncogene from the human bladder carcinoma cell line T24 exhibit several characteristics of transformed cells but do not acquire an infinite life-span and are not tumorigenic. 2643097 1989
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 GeneticVariation disease BEFREE c-Ha-ras-1 alleles in bladder cancer, Wilms' tumour and malignant melanoma. 2892780 1988
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 Biomarker disease BEFREE Activation and/or overexpression of the protein product of the ras gene family (p21ras) has been implicated in the development of various cancers, including bladder carcinoma. 3057152 1988
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 AlteredExpression disease BEFREE Malignant properties of sublines selected from a human bladder cancer cell line that contains an activated c-Ha-ras oncogene. 3409229 1988
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 Biomarker disease BEFREE Chromosomes isolated from a human bladder carcinoma cell line which contains the actively transforming oncogene HRAS1 on chromosome 11 can be used to transform mouse cells. 3474107 1987
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 GeneticVariation disease BEFREE On the other hand, deletion of one Ha-ras allele was observed in 1 of 5 cases of bladder cancer and in 2 of 3 cases of renal pelvic cancer, suggesting that that deletion may be important in the development of urothelial cancer. 2889677 1987
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.700 AlteredExpression disease BEFREE Suppression of tumorigenicity with continued expression of the c-Ha-ras oncogene in EJ bladder carcinoma-human fibroblast hybrid cells. 3523486 1986