Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The activity of the glucocorticoid activating enzyme, 11β-hydroxysteroid dehydrogenase type-1 (11βHSD1) is altered in diseases such as obesity, inflammation and psychiatric disorders.
|
31677354 |
2019 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The steadily increasing epidemic of obesity continues at alarming rates, is an important public health problem, and expression changes of S100A16 and 11 β-hydroxysteroid dehydrogenase type 1(11β-HSD1) is attributable to the adipocyte differentiation.
|
31399502 |
2019 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Studies have implicated 11β-HSD1 in metabolic diseases including type 2 diabetes and obesity, as well as stress-related disorders and neurodegenerative diseases, such as depression and Alzheimer's disease (AD).
|
30689943 |
2019 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the link between the role of 11β-HSD1 in the hypothalamus and obesity has yet to be determined.
|
29418022 |
2018 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, 11β-HSD1 is a promising target for the treatment and prevention of type 2 diabetes mellitus with obesity.
|
29078846 |
2017 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
This mini-review will focus on 11β-HSD1 in skeletal muscle and its postulated link to obesity and insulin-resistance.
|
28765040 |
2017 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
It has been reported that too much cortisol or overexpression of HSD11B1 induces obesity and the insulin resistance that accompanies metabolic syndrome in rodent adipose tissue.
|
29206210 |
2017 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, 11β-HSD1 was expressed in crown ATMs in obese AT.
|
27698011 |
2016 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that 11β-HSD1 activity is dysregulated in obesity and alters following bariatric surgery induced weight loss in different tissues.
|
25603461 |
2015 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To investigate the relationship between 11β-hydroxysteroid dehydrogenase (HSD11B) gene type 1 and 2 and obesity in Chinese children.
|
24729284 |
2014 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Several selective 11βHSD1 inhibitors have now been developed and shown to improve metabolic dysfunction in patients with type 2 diabetes, but the small magnitude of the glucose-lowering effect has precluded their further commercial development.This review focuses on the role of 11βHSD1 as a tissue-specific regulator of cortisol exposure in obesity and type 2 diabetes in humans.
|
24710966 |
2014 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Homozygosity for 11-βHSD1 4478G/G was absent with no association with parameters of obesity and insulin resistance.
|
24078163 |
2013 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study suggests that there are sex differences in 11β-HSD1 regulation and in its associations with markers of obesity and IR.
|
23701286 |
2013 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A novel SNP, rs3753519, was strongly associated with obesity and this SNP was the only statistically significant HSD11B1 gene SNP remaining after a Bonferroni correction (odds ratio=1.97 for allelic effect, 95% confidence interval 1.23-3.16; P=0.004 and Bonferroni corrected P=0.046).
|
22310475 |
2012 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We suggest that the disruption of Ifi202b in B6 is responsible for the effects of the obesity QTL Nob3, and that Ifi202b modulates fat accumulation through expression of adipogenic genes such as 11β-Hsd1.
|
22692684 |
2012 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To further characterize the tissue-specific cortisol regeneration in obesity, we have investigated the mRNA expression of genes related to local cortisol production, i.e., 11β-HSD1, hexose-6-phosphate dehydrogenase (H6PDH) and cortisol action, glucocorticoid receptor (GR) and a cortisol target gene, phosphoenolpyruvate carboxykinase (PEPCK) in the liver, and visceral (VAT) and subcutaneous (SAT) adipose tissues from morbidly obese patients with and without metabolic syndrome (MS).
|
21964795 |
2012 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in 11-β hydroxysteroid dehydrogenase type 1 (11β-HSD1, encoded by HSD11B1) have been reported to be associated with obesity-related cardiovascular risk factors, such as type II diabetes and hypertension.
|
21402901 |
2011 |
Obesity
|
0.600 |
Biomarker
|
disease |
CTD_human |
Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase type 1.
|
21786805 |
2011 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The overexpression of liver reductases in obesity could be an adaptive response to an increase in cortisol production by the liver and visceral 11β-HSD1 to avoid systemic hypercortisolism.
|
21704348 |
2011 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in HSD11B1, the gene encoding 11β-hydroxysteroid dehydrogenase type 1 enzyme, have been associated with obesity, metabolic syndrome, and type 2 diabetes.
|
21117953 |
2011 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The impact of adipose tissue cortisol reactivation by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) on markers of obesity and IR was assessed in PCOS patients.
|
21147223 |
2011 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Regeneration of cortisol by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) within liver and adipose tissue may be of pathophysiological importance in obesity and the metabolic syndrome. single nucleotide polymorphisms (SNPs) in HSD11B1, the gene encoding 11β-HSD1, have been associated with type 2 diabetes and hypertension in population-based cohort studies, and with hyperandrogenism in patients with the polycystic ovary syndrome (PCOS).
|
21622477 |
2011 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Animal studies indicate a role for 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) in the development of obesity.
|
20381186 |
2010 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The current obesity epidemic, however, is not characterized by increased plasma cortisol concentrations, but instead comes along with chronic low-grade inflammation in adipose tissue and concomitant increased levels of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1, gene HSD11B1), a parameter known to cause obesity in a mouse model.
|
20045052 |
2010 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that obesity and elevated intracranial pressure may be linked through increased 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity.
|
20826586 |
2010 |