Essential Hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Parallel observations in gut microbiology coupled with screening of endogenous steroids as inhibitors of 11β-HSD2 have implicated particular gut bacteria in essential hypertension through the production of glycerrhetinic acid-like factors (GALFs).
|
28624548 |
2017 |
Essential Hypertension
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As 50% of patients with essential hypertension are insulin resistant and hyperinsulinemic, we hypothesized that insulin downregulates the 11beta-HSD2 activity.
|
25133511 |
2014 |
Essential Hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whereas mutations or inhibition of 11βHSD2 by licorice have been clearly shown to produce a congenital or acquired syndrome of mineralocorticoid excess, the questions remaining are the extent to which subtle abnormalities in MR/11βHSD2 mechanisms may contribute to essential hypertension.
|
19909806 |
2010 |
Essential Hypertension
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Taken together, our results indicate that missense mutations in HSD11B2 do not substantially contribute to essential hypertension in Japanese.
|
16778331 |
2006 |
Essential Hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analysis of the 11beta-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) in human essential hypertension.
|
16109323 |
2005 |
Essential Hypertension
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Role of HSD11B2 polymorphisms in essential hypertension and the diuretic response to thiazides.
|
15673310 |
2005 |
Essential Hypertension
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Impaired 11-beta hydroxysteroid dehydrogenase type 2 activity in sweat gland ducts in human essential hypertension.
|
14981055 |
2004 |
Essential Hypertension
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of 11beta-HSD2 explains the mineralocorticoid excess state seen following liquorice ingestion and more subtle defects in enzyme expression might be involved in the pathogenesis of 'essential' hypertension.
|
12943516 |
2003 |
Essential Hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
HSD11B2 does not have a strong influence on the development of essential hypertension in Black people, but weaker effects on blood pressure cannot be ruled out.
|
11531933 |
2001 |
Essential Hypertension
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To address this, the coding sequences of the 11BHSD2 gene was screened for mutations in 20 patients with primary hypertension with single strand conformation polymorphism and direct DNA sequencing techniques.
|
11114699 |
2000 |
Essential Hypertension
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hypertension with no other characteristic signs of AME was found in the heterozygous father of a child with AME, and we described a girl with a homozygous gene mutation resulting in only a slightly reduced 11 beta HSD2 activity causing 'essential' hypertension.
|
10726708 |
2000 |
Essential Hypertension
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In normals or in subjects with essential hypertension, sensitivity of blood pressure to salt loading is correlated with activity of renal 11-HSD2, as measured by an increase in the ratio of urinary free cortisol/urinary free cortisone (UFF/UFE), and also correlated with length of a CA repeat polymorphism in the first intron of HSD11B2.
|
11196453 |
2000 |
Essential Hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, while some studies demonstrate impaired 11beta-HSD activity in broader populations of patients with hypertension, further studies are required to clarify the role of 11beta-HSD2 in 'essential' hypertension.
|
10419018 |
1999 |
Essential Hypertension
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data do not suggest that variants of the 11beta-HSD2 gene contribute substantially to essential hypertension in Caucasians.
|
9856363 |
1998 |
Essential Hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hypertensive populations should be screened to identify the prevalence of milder defects in 11beta-HSD2 in patients currently labeled as having "essential" hypertension.
|
9683587 |
1998 |
Essential Hypertension
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data indicate the presence of a polymorphic marker in exon 3 of the HSD11B2 gene; this marker is associated with end-stage renal disease but not with essential hypertension in humans.
|
9589699 |
1998 |
Essential Hypertension
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Further studies are now required in order to evaluate the role of 11beta-HSD2 activity in the pathophysiology of 'essential' hypertension.
|
9431844 |
1997 |
Essential Hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic association of 11 beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) flanking microsatellites with essential hypertension in blacks.
|
8794836 |
1996 |