HTR1A, 5-hydroxytryptamine receptor 1A, 3350

N. diseases: 229; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Thus, epistasis between BDNF and HTR1A may contribute to the multifactorial risk for affective disorders and our results strongly advocate further research on this genetic signature in affective disorders. 30664620 2019
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE The primary goal of this study was to determine the possible association between polymorphisms of genes encoding the serotonin receptors 5HT1A (rs6295), 5HT1B (rs6296), and 5HT2C (rs6318) and the presence of mood disorders in patients with TLE-HS. 29709878 2018
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE The serotonin-1A (5-HT1A) receptor is strongly implicated in major depression and other affective disorders due to its negative regulation of serotonin neurone firing rates. 28970569 2017
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE The clinical implications of targeting alexithymia and HTR1A receptors as a possible treatment option for mood disorders should be investigated in further studies. 26609890 2015
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE This study suggests that serotonin signaling through postsynaptic 5-HT1A receptors in the hippocampus is critical for the antidepressant-like effects of a cholinergic drug and begins to elucidate the molecular mechanisms underlying interactions between the serotonergic and cholinergic systems related to mood disorders. 25288485 2015
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE History of mood disorders and HTR1A G allele variation, the C-1019G polymorphism of the transcriptional control region of the 5-HT1A receptor, independently predicted the incidence of IFN-induced depression in HCV patients, whether separately or jointly considered and although not reciprocally associated. 26001668 2015
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group PSYGENET In MDD, however, the effect of the val66met polymorphism is not detectable, possibly due to a ceiling effect of over-expression of 5-HT(1A) receptors in mood disorders. 24607934 2014
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE In MDD, however, the effect of the val66met polymorphism is not detectable, possibly due to a ceiling effect of over-expression of 5-HT(1A) receptors in mood disorders. 24607934 2014
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group PSYGENET RGS6 is enriched in hippocampal and cortical neurons, 5-HT(1A)R-expressing cells implicated in mood disorders. 24421401 2014
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group PSYGENET Results from this expanded meta-analysis, which included our own new study, suggest that rs6295 (C-1019G) and rs878567 in HTR1A are related to the pathophysiology of MDs, with overlap between MDD and BP. 22752684 2013
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE Results from this expanded meta-analysis, which included our own new study, suggest that rs6295 (C-1019G) and rs878567 in HTR1A are related to the pathophysiology of MDs, with overlap between MDD and BP. 22752684 2013
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group PSYGENET Altered regulation of the serotonin-1A (5-HT1A) receptor gene is implicated in major depression and mood disorders. 22232550 2012
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group PSYGENET Due to its modulatory effect on serotonin (5-HT) release, the 5-HT(1A)-receptor is thought to play a decisive role in the therapy of this mood disorder. 21419787 2011
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Serotonin (5-hydroxytryptamine, 5-HT) neurotransmission is negatively regulated by 5-HT1A autoreceptors on raphe neurons, and is implicated in mood disorders. 21182526 2011
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE Three genes contributed exclusively to mood disorders, one through a main effect (HTR5A (rs1657268)) and two through gene-environment interactions with CPA (HTR1A (rs878567) and SLC6A4 (rs3794808)). 19381154 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 AlteredExpression group BEFREE Altered expression of serotonin-1A (5-HT1A) receptors, both presynaptic in the raphe nuclei and post-synaptic in limbic and cortical target areas, has been implicated in mood disorders such as major depression and anxiety. 19423080 2009
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE 5-HT1A gene variants have been reported to play some role in mood disorders, anxiety disorders and psychotic disorders. 18047755 2008
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE Gene-gene interaction studies suggest that the 5-HT1A receptor G(-1019) allele is a risk allele which could be used as a marker for depression and related mood disorders. 18639564 2008
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 AlteredExpression group BEFREE Alterations in 5-HT1A receptor levels are implicated in mood disorders, and a functional C(-1019)G 5-HT1A promoter polymorphism has been associated with depression, suicide, and panic disorder. 16467535 2006
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE These results indicate an important (mainly inhibitory) role of galanin as a regulator of brain serotonin and 5-HT1A receptor-mediated transmission, which may be of potential importance for understanding mood disorders and for the development of antidepressant drugs. 16863269 2006
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE 5-HT 1A polymorphism and self-transcendence in mood disorders. 15952185 2005
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group LHGDN We tested involvement of 5-HT(1A) gene in this trait, in a sample of 40 remitted mood disorder patients. 15952185 2005
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings. 15458611 2004
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group LHGDN Alterations in 5-HT(1A,) 5-HT(1B), and 5-HT(2A) mRNA levels in the brains of subjects with both mood disorders and schizophrenia add further support for hypothesis of dysregulation of the serotonergic system in these psychiatric disorders. 14744462 2004
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Alterations in 5-HT(1A,) 5-HT(1B), and 5-HT(2A) mRNA levels in the brains of subjects with both mood disorders and schizophrenia add further support for hypothesis of dysregulation of the serotonergic system in these psychiatric disorders. 14744462 2004