Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, the 5-HT1A receptor gene illustrates the convergence of genetic, epigenetic and posttranscriptional mechanisms in gene expression, neurodevelopment and neuroplasticity, and major depression.
|
30807072 |
2019 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
<b>Conclusions:</b> The interactions between 5-HT1A and VEGF gene polymorphisms may play a key role in the development of MDD in the Northern Chinese Han population.
|
31057436 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Vilazodone, a combined serotonin reuptake inhibitor and 5-HT1A partial agonist, is an approved therapy for the treatment of MDD and which has been further investigated for GAD.
|
30475091 |
2019 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A preliminary association study between serotonin transporter (5-HTTLPR), receptor polymorphisms (5-HTR1A, 5-HTR2A) and depression symptom-clusters in a north Indian population suffering from Major Depressive Disorder (MDD).
|
31228794 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
We also present clinical data that show promise for identifying biomarkers of 5-HT activity, 5-HT1A regulation and regional changes in brain activity in MDD patients that may provide biomarkers for tailored interventions to overcome or bypass resistance to SSRI treatment.
|
31114473 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The 5-HT1A autoreceptor mediates feedback inhibition of serotonin (5-HT) neurons, and is implicated in major depression.
|
29636529 |
2018 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The serotonin receptor 1A and 1B (HTR1A/1B) gene have been suggested to be involved in the pathogenesis of major depressive disorder (MDD) and the antidepressant treatment response.
|
29275155 |
2018 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
A Novel Alternative Splicing Mechanism That Enhances Human 5-HT1A Receptor RNA Stability Is Altered in Major Depression.
|
30093565 |
2018 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The common polymorphism rs6295 of the serotonin-1A receptor gene (HTR1A) is affecting the transcriptional regulation of the 5-HT<sub>1A</sub> receptor and has been closely linked to MDD.
|
28608854 |
2017 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to explore whether the variants in the 5-HT1A and 5-HT2A gene are susceptible to SZ or MDD in the Chinese Han population.
|
27756686 |
2016 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The purpose of this review is to describe the evolution of our current understanding of the serotonin 1A (5-HT1A) receptor and its role in the pathophysiology MDD through the discussion of animal, post-mortem, positron emission tomography (PET), pharmacologic and genetic studies.
|
26851834 |
2016 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This article evaluates the role of 5-HT1A-R genotypes on the profile of cognitive function in patients with major depressive disorder (MDD).
|
26780922 |
2016 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Multiple lines of research have implicated the serotonin 1A (5-HT1A) receptor in major depressive disorder (MDD).
|
25578798 |
2015 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
A total of 26 outpatients with treatment-resistant MDD and 27 matched healthy controls underwent magnetic resonance imaging and genotyping for six SNPs in monoaminergic genes [serotonin transporter (SLC6A4), norepinephrine transporter (SLC6A2), serotonin 1A and 2A receptors (HTR1A and HTR2A), catechol-O-methyltransferase (COMT), and brain-derived neurotrophic factor (BDNF)].
|
25990886 |
2015 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In MDD, however, the effect of the val66met polymorphism is not detectable, possibly due to a ceiling effect of over-expression of 5-HT(1A) receptors in mood disorders.
|
24607934 |
2014 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Interaction of 5-HTT and HTR1A gene polymorphisms in treatment responses to mirtazapine in patients with major depressive disorder.
|
24911443 |
2014 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In MDD, however, the effect of the val66met polymorphism is not detectable, possibly due to a ceiling effect of over-expression of 5-HT(1A) receptors in mood disorders.
|
24607934 |
2014 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Transcriptional dys-regulation in anxiety and major depression: 5-HT1A gene promoter architecture as a therapeutic opportunity.
|
24180393 |
2014 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Somatodendritic 5-hydroxytryptamine1A (5-HT1A) autoreceptor function in major depression as assessed using the shift in electroencephalographic frequency spectrum with buspirone.
|
23809646 |
2014 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Somatodendritic 5-hydroxytryptamine1A (5-HT1A) autoreceptor function in major depression as assessed using the shift in electroencephalographic frequency spectrum with buspirone.
|
23809646 |
2014 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Transcriptional dys-regulation in anxiety and major depression: 5-HT1A gene promoter architecture as a therapeutic opportunity.
|
24180393 |
2014 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interaction of 5-HTT and HTR1A gene polymorphisms in treatment responses to mirtazapine in patients with major depressive disorder.
|
24911443 |
2014 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Preclinical and imaging/post-mortem studies in humans provide strong support for the involvement of HTR1A and HTR2A genes in MD.
|
23547754 |
2013 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The serotonin 1A receptor gene (HTR1A) has been associated with mood disorders (MDs), including major depressive disorder (MDD) and bipolar disorder (BP).
|
22752684 |
2013 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
To further explore the genetic components of MDD and utility of 5-HT(1A) imaging as a potential tool for biomarker or treatment response prediction, these findings should be replicated in a larger cohort using the [(11)C]CUMI-101 agonist tracer.
|
23440462 |
2013 |