|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our findings may help to improve the understanding of the relationship between 5-HT2A and DRD3 genotypes and schizophrenia pathogenesis.
|
31813806 |
2019 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in DRD2 and 5-HT2 receptor genes are associated with schizophrenia in North Indian population.
|
30389402 |
2019 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We evaluated whether MIN-101, a molecule that combines sigma-2 antagonism and 5-HT2A antagonism, might improve cognitive deficits in individuals with moderate to severe negative symptoms in schizophrenia.
|
29873956 |
2019 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Dopamine (DRD2) and Serotonin (HTR2A, 2C) Receptor Gene Polymorphisms do not influence early response to Risperidone in South Indian Patients with Schizophrenia.
|
30332506 |
2019 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
5-HT2A receptors are altered in schizophrenia and represent drug target for antipsychotic therapeutic activity.
|
31618004 |
2019 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The inbred Roman High- (RHA-I) and Low- (RLA-I) Avoidance rat strains are a congenital neurobehavioral model, with the RHA-I displaying schizophrenia-related behaviors and serotonin 2A (5-HT2A) and metabotropic glutamate 2 (mGlu2) receptor alterations in the prefrontal cortex (PFC).
|
31228641 |
2019 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
With regard to the serotonergic system, 5-HT1A and 5-HT2A receptors have been studied in the context of cognitive functions in schizophrenia.
|
29896132 |
2018 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The serotonin (5-HT) 5-HT2A receptor (5-HT2AR) and 5-HT2C receptor (5-HT2CR) in the central nervous system are implicated in a range of normal behaviors (e.g., appetite, sleep) and physiological functions (e.g., endocrine secretion) while dysfunctional 5-HT2AR and/or 5-HT2CR are implicated in neuropsychiatric disorders (e.g., addiction, obesity, schizophrenia).
|
30157263 |
2018 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In summary, these data suggest that a shift towards increased availability (and G-protein coupling) of cortical 5-HT2A vs. mGlu2 receptors may represent a common neurobiological mechanism underlying the emergence of psychosis and cognitive deficits observed in subjects with meth use disorder and schizophrenia.
|
30240581 |
2018 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
There actually exists significant implication of CYP2D6 genetic polymorphisms on the metabolic kinetics of risperidone, little is known about the extent of CYP2D6 impacting human D2 and 5-HT2A receptor occupancies as well as the clinical efficacy and efficacy in schizophrenia treatment.
|
30281999 |
2018 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Neuromodulation of neuronal networks in schizophrenia via DA, adenosine, glutamate, 5-HT and neurotensin peptides and oxytocin, involving A2AR-D2R, D2R-NMDAR, A2AR-D2R-mGluR5, D2R-5-HT2A and D2R-oxytocinR heteroreceptor complexes opens up a new world of D2R protomer targets in the listed heterocomplexes for treatment of positive, negative and cognitive symptoms of schizophrenia.
|
28270751 |
2017 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Three CpG sites were hypermethylated in schizophrenia (cg5 <i>p</i> = 0.028, cg7 <i>p</i> = 0.021, cg10 <i>p</i> = 0.017) and <i>HTR2A</i> polymorphisms rs6314 (<i>p</i> = 0.008) and rs6313 (<i>p</i> = 0.026) showed genetic association with schizophrenia.
|
28054990 |
2017 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results add experimental evidence to the view that RHA-I rats represent a model with predictive and construct validity of some dopamine and 5-HT2A receptor-related features of schizophrenia.
|
28154892 |
2017 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Interaction between Methylation and CpG Single-Nucleotide Polymorphisms in the HTR2A Gene: Association Analysis with Suicide Attempt in Schizophrenia.
|
26812280 |
2016 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.
|
26758213 |
2016 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to explore whether the variants in the 5-HT1A and 5-HT2A gene are susceptible to SZ or MDD in the Chinese Han population.
|
27756686 |
2016 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Dopamine D2 and serotonin 5-HT2A receptors contribute to modulate prefrontal cortical physiology and response to treatment with antipsychotics in schizophrenia.
|
25563748 |
2015 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A number of studies have assessed a relationship between the T102C polymorphism in the HTR2A gene with an increased risk of major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SCZ).
|
24962835 |
2014 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To use a hierarchical approach to determine the functional effects of this single-nucleotide polymorphism on 5-HT2AR messenger RNA and protein expression, on prefrontal phenotypes linked with genetic risk for schizophrenia, and on treatment with olanzapine.
|
23842608 |
2013 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We hypothesize that the 5-HT2A receptor gene is a modifier gene of schizophrenia and suggest that additional studies are warranted.
|
23063294 |
2013 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
RGD |
Chronic administration of risperidone in a rat model of schizophrenia: a behavioural, morphological and molecular study.
|
23291154 |
2013 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Increased expression and activity of cortical 5-HT2A receptors has been associated with neuropsychiatric disorders, such as anxiety and schizophrenia.
|
23592773 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the HTR2A T102C polymorphism may confer susceptibility to schizophrenia in Han Chinese.
|
23857788 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We found that the association of the HTR2A -1438A/G polymorphism with SZ depends on the ethnic origin of the study population, and this genetic variant does not modify the susceptibility to BD or MDD.
|
23404241 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Cytosine methylation of HTR2A at T102C polymorphic site in DNA derived from the saliva can potentially be used as a diagnostic, prognostic, and/or therapeutic biomarker in SCZ and BD.
|
21598376 |
2011 |