Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Interaction of TPH2 and 5-HT2A Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study.
|
31019472 |
2019 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to determine the relationship between the polymorphisms of -1438A/G and 102T/C in the 5-HT2A receptor (HTR2A) gene and nausea/vomiting as a side effect induced by sertraline (SERT) or citalopram (CIT) in patients with major depressive disorder.
|
30221791 |
2018 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Neuroimaging, immunologic, and pharmacologic studies have emphasized the role of 5-HT2A and 5-HT3A serotonin receptors in the pathophysiology of major depression.
|
28125323 |
2017 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association study of 5-HT1A, 5-HT2A polymorphisms with schizophrenia and major depressive disorder in the Han Chinese population.
|
27756686 |
2016 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Converging translational evidence for the involvement of the serotonin 2A receptor gene in major depressive disorder.
|
24801750 |
2014 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Influence of 5-HTR2A genetic polymorphisms on the efficacy of antidepressants in the treatment of major depressive disorder: a meta-analysis.
|
25108775 |
2014 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia.
|
24962835 |
2014 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis.
|
25270656 |
2014 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia.
|
24962835 |
2014 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis.
|
25270656 |
2014 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Influence of 5-HTR2A genetic polymorphisms on the efficacy of antidepressants in the treatment of major depressive disorder: a meta-analysis.
|
25108775 |
2014 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
HTR2A-1438A/G polymorphism influences the risk of schizophrenia but not bipolar disorder or major depressive disorder: a meta-analysis.
|
23404241 |
2013 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several studies in major depression have implicated a role of the serotonin receptor gene (HTR2A) in treatment response to antidepressants.
|
22006095 |
2013 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Preclinical and imaging/post-mortem studies in humans provide strong support for the involvement of HTR1A and HTR2A genes in MD.
|
23547754 |
2013 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
5-HT2A receptor -1438 G/A polymorphism and serotonergic antidepressant-induced sexual dysfunction in male patients with major depressive disorder: a prospective exploratory study.
|
22612784 |
2012 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
5-HT2A receptor -1438 G/A polymorphism and serotonergic antidepressant-induced sexual dysfunction in male patients with major depressive disorder: a prospective exploratory study.
|
22612784 |
2012 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate the influence of a HTR2A polymorphism on aspects of somatization in major depression, which co-occurs with an unfavorable antidepressant treatment outcome.
|
21838737 |
2011 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.
|
21136126 |
2010 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
HTR2A is associated with SSRI response in major depressive disorder in a Japanese cohort.
|
19937159 |
2010 |
Unipolar Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
While further work is needed to identify the actual functional genetic variants involved, these results suggest that a relationship exists between genetic variation in HTR2A and either 5-HTT expression or central serotonergic transmission that influences the therapeutic response to 5-HTT inhibition in major depression.
|
20047709 |
2010 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population.
|
19428704 |
2009 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.
|
19590397 |
2009 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the HTR2A gene, were studied in 420 patients with MD to investigate the relationship between these genes and suicidal ideation in MD.
|
19897250 |
2009 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The serotonin 2A (5-HT2A) receptor gene has been implicated in the pathogenesis of suicidal behavior by a genetic association between the 5-HT2A C102T silent polymorphism and suicidality in patients with major depression.
|
17221840 |
2007 |