APOB, apolipoprotein B, 338

N. diseases: 339; N. variants: 122
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 Biomarker phenotype BEFREE Abnormalities of lipid metabolism in NS include hypertriglyceridemia and hypercholesterolemia due to elevated apolipoprotein B-containing lipoproteins, decreased lipoprotein lipase and hepatic lipase activity, increased hepatic PCSK9 levels, and reduced hepatic uptake of high-density lipoprotein. 31302760 2019
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 AlteredExpression phenotype BEFREE The evolution of apolipoprotein B and its mRNA editing complex. Does the lack of editing contribute to hypertriglyceridemia? 29031774 2018
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 Biomarker phenotype BEFREE Apolipoprotein B lipoproteins (apoB lipoproteins) induce white adipose tissue (WAT) dysfunction, which in turn promotes postprandial hypertriglyceridemia, insulin resistance (IR), and hyperinsulinemia. 29917037 2018
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 Biomarker phenotype BEFREE Non-HDL cholesterol or apolipoprotein B should be used as secondary therapeutic target in patients with mild-to-moderate hypertriglyceridemia, 2-10 mmol/l (175-880 mg/dl). 30120626 2018
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 Biomarker phenotype BEFREE apoB = apolipoprotein B; apoC-III = apolipoprotein CIII; ASO = antisense oligonucleotide; FCS = familial chylomicronemia syndrome; HTG = hypertriglyceridemia; LPL = lipoprotein lipase; LPLD = lipoprotein lipase deficiency. 30183397 2018
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 Biomarker phenotype BEFREE Non-HDL cholesterol (or apoB) should be the secondary treatment target in patients with mild to moderate hypertriglyceridemia, in whom LDL cholesterol measurement or calculation is less accurate and often less predictive of cardiovascular risk. 29760220 2018
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 AlteredExpression phenotype BEFREE Serum triglyceride, HDL-C, and apoB levels were independently associated with CHD in a Chinese population undergoing coronary angiography with a relatively low level of LDL-C and a high prevalence of hypertriglyceridemia and low HDL-C. 28506386 2017
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 AlteredExpression phenotype BEFREE Fasting apoB-48 levels correlate with the morbidity of postprandial hypertriglyceridemia, obesity, type III hyperlipoproteinemia, the metabolic syndrome, hypothyroidism, chronic kidney disease, and IGT. 27829582 2017
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 AlteredExpression phenotype BEFREE LPL p.474X and FABP2 p.55T were associated with decreased total cholesterol and LDL-C, respectively; APOA5 p.19W with increased HDL-C; APOA5 p.19W and FABP2 p.55T with increased triglycerides; and APOB p.4181K and LDLR c.1959T with decreased triglycerides. 25587205 2014
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 AlteredExpression phenotype BEFREE The results presented here indicate that elevated ApoB-100 level and the consequent chronic hypertriglyceridemia may lead to impaired neuronal function and neurodegeneration, possibly via hyperphosphorylation of tau protein. 23029362 2012
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 GeneticVariation phenotype BEFREE In contrast, common complex HTG results from the cumulative influence of small-effect variants (single nucleotide polymorphisms) in genes such as APOA5, GCKR, LPL, and APOB. 21519249 2011
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 Biomarker phenotype BEFREE Through GWAS, we identified common variants in APOA5, GCKR, LPL and APOB associated with HTG. 20657596 2010
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 Biomarker phenotype CTD_human Through GWAS, we identified common variants in APOA5, GCKR, LPL and APOB associated with HTG. 20657596 2010
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 AlteredExpression phenotype BEFREE Hypertriglyceridemia is an independent risk factor in the development of cardiovascular diseases, and we have previously reported that oral administration of a grape seed procyanidin extract (GSPE) drastically decreases plasma levels of triglycerides (TG) and apolipoprotein B (ApoB) in normolipidemic rats, with a concomitant induction in the hepatic expression of the nuclear receptor small heterodimer partner (NR0B2/SHP). 18720348 2008
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 Biomarker phenotype BEFREE Insulin-resistant apoB/BATless mice have hypertriglyceridemia because of increased assembly and secretion of very low density apolipoprotein B (apoB) and triglycerides compared with mice expressing only apoB (Siri, P., Candela, N., Ko, C., Zhang, Y., Eusufzai, S., Ginsberg, H. N., and Huang, L. S. (2001) J. Biol.Chem.276, 46064-46072). 16971390 2006
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 Biomarker phenotype BEFREE The authors report a case regarding a 7-year-old girl affected by short height, bone growth delay, lipidic alterations (hypercholesterolemia, hypertriglyceridemia and high apolipoprotein B values) and by a partial duplication of the short arm of the third chromosome: 46,XX, dup(3)(p26-pter). 10546407 1999
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 Biomarker phenotype RGD Mechanism of hypertriglyceridemia in Dahl salt-sensitive rats, an animal model of spontaneous nephrotic syndrome. 8121310 1994
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.600 Biomarker phenotype BEFREE After an oral fat load, the repartition of the two species of apolipoprotein B did not change greatly (respective percentages, 60% and 40%), and the concentration of serum triglyceride increased only from 1.20 to 1.65 mmol/L. 1993347 1991