APOB, apolipoprotein B, 338

N. diseases: 339; N. variants: 122
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 AlteredExpression disease BEFREE Baseline LDL-C, non-high-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and apolipoprotein B levels were lower and lipoprotein(a) higher in patients with than without prior MI/ischemic stroke. 31076261 2020
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 GeneticVariation disease BEFREE Subgroup or meta-analyses of several RCTs, IVUS imaging studies, and the ACS population in IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) supported the evidence-based 2017 American Association Clinical Endocrinologist (AACE) guideline change establishing a targeted LDL-C goal < 55 mg/dL, non-HDL-C < 80 mg/dl, and apolipoprotein B (apo B) < 70 mg/dL for patients at "Extreme" ASCVD risk, i.e., 10-year 3-point-MACE-composite (CV death, non-fatal MI, or ischemic stroke) risk exceeding 30%. 31754844 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker disease BEFREE Further, in 108,602 individuals from the Copenhagen General Population Study in random nonfasting samples, the highest versus the lowest quartile of triglycerides, total cholesterol, LDL cholesterol, remnant cholesterol, non-HDL cholesterol, lipoprotein(a), and apolipoprotein B were all associated with higher risk of both ischaemic heart disease and myocardial infarction. 30522787 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 GeneticVariation disease BEFREE This study enrolled PMI patients (n = 225) and detected the mutations in their FH-associated genes (LDLR, APOB, PCSK9, LDLRAP1) by Sanger sequencing. 30971288 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 GeneticVariation disease BEFREE We analyzed in detail the associations of rs693 and rs562338 polymorphisms representing the Apolipoprotein B locus with endophenotypes (total cholesterol [TC] and high-density lipoprotein cholesterol) and phenotypes (myocardial infarction [MI] and survival) in four large-scale studies, which include 20 748 individuals with 2357 MI events. 27683205 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 GeneticVariation disease BEFREE A marginal relationship between ApoB XbaI polymorphism and MI was found under a dominant genetic model (OR: 1.083, 95% CI: 1.004-1.168, P = 0.039). 25083581 2014
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 GeneticVariation disease BEFREE While power limited one's ability to detect significance for association of individual loci with myocardial infarction, the authors found significance for loci associated with LDL, HDL, apoB and triglycerides, replicating previous observations. 24386469 2013
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 AlteredExpression disease BEFREE Although GCKR CT (46%) and TT (14%) versus CC (40%) genotypes had effects on triglycerides (+0.17 mmol/L; trend, P<0.001), remnant cholesterol (+0.07 mmol/L; P<0.001), and apolipoprotein B (+4.6 mg/dL; P<0.001) similar to those of TRIB1, GCKR did not influence low-density lipoprotein cholesterol levels or risk of IHD or MI. 21071687 2011
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker disease BEFREE Levels of LDL cholesterol and apolipoprotein B and risk of ischemic heart disease and myocardial infarction were measured. 18160469 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 GeneticVariation disease BEFREE In the present study, the first investigation of the Ins/Del polymorphism of the APOB gene in Tunisian patients with MI, we examined a possible association between this polymorphism and MI in a subgroup of the Tunisian population. 18590467 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 GeneticVariation disease BEFREE We compared plasma total cholesterol (TC)/high density lipoprotein-C (HDL-C) and apolipoprotein B (APOB)/apolipoprotein AI (APOAI) ratios among the groups and mutation carriers and non-carriers, and the prevalence of the mutations in G1 and G2 patients with multiple coronary vessel disease (MVD) and myocardial infarction (MI). 18609106 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker disease LHGDN ApoB-100 and ApoB/ApoA-1 ratio in children and adolescents from families with very early myocardial infarction. 16801176 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker disease BEFREE ApoB-100 and ApoB/ApoA-1 ratio in children and adolescents from families with very early myocardial infarction. 16801176 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 GeneticVariation disease LHGDN [Apolipoprotein B: structure, function, gene polymorphism, and relation to atherosclerosis]. 16007035 2005
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 GeneticVariation disease BEFREE Similarly, for the apolipoprotein B Asn4311Ser and Thr71Ile polymorphisms, genotypes associated with more adverse plasma apolipoprotein concentrations were associated with significantly lower risk of MI after adjustment for the apoB/apoA(1) ratio. 15256516 2004
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 GeneticVariation disease LHGDN APO B gene polymorphisms and coronary artery disease: a meta-analysis. 12818419 2003
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker disease LHGDN Apolipoproteins A-1 and B and the likelihood of non-fatal stroke and myocardial infarction -- data from The Third National Health and Nutrition Examination Survey. 12011770 2002
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker disease BEFREE Subjects whose father (n=112), mother (n=115) or both parents (n=115) suffered from a premature MI presented with significantly higher apolipoprotein B (apo B) levels than subjects without a parental history (n=114). 11223436 2001
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 GeneticVariation disease BEFREE The results suggest that in Polish population the individuals with P2 allele of the apolipoprotein B gene are at increased risk of developing myocardial infarction. 11208426 2001
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 GeneticVariation disease BEFREE Polymorphisms at the apolipoprotein B (APOB XbaI, EcoRI, insertion-deletion), apolipoprotein E (APOE), and angiotensin-converting enzyme (ACE) loci are thought to be involved in susceptibility to coronary artery disease (CAD) and myocardial infarction. 10592684 1999
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 GeneticVariation disease BEFREE The present study presents evidence for a statistically significant difference in the development of MI between genotype classes of the apoB SP Ins/Del gene polymorphism. 9863550 1998
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker disease BEFREE Smoking, apolipoprotein B and history of hypertension were found to be independent predictors of CAD and MI. 9693941 1998
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker disease BEFREE Apolipoprotein B as well as the ratios total/HDL cholesterol, LDL/HDL cholesterol and Apo B/AI were less effective predictors than LDL cholesterol and did not contribute independently to the estimation of MI risk. 9105565 1997
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 GeneticVariation disease BEFREE To determine whether the APOE association may be a risk factor for coronary disease as well, we examined two APOB gene restriction sites that have previously been found to be associated with coronary artery disease, especially myocardial infarctions. 8530010 1995
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker disease BEFREE The boys having the highest decile values of triglyceride, ratios of LDL/HDL-cholesterol, total/HDL-cholesterol and apolipoprotein B/A-I, and cumulative skin-fold thickness, a marker of obesity, had higher family history scores and increased occurrence of myocardial infarction in their families than the boys with the lowest decile values of these variables. 8021052 1994