Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The study suggests that genetic variants inGPC5, CD58 and IRF8 genes may be of clinical interest in MS as predictors of age of onset and response to therapy.
|
30818222 |
2019 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, we identified one SNP located in the PHDGH gene and another on IRF8 gene that were associated with MP2K1 phosphorylation levels, providing a first clue on how this MS risk gene may act.
|
31004050 |
2019 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The genetic variant of the INF regulatory factor 8 (IRF8), a type 1 INF regulator, is associated with susceptibility to systemic lupus erythematosus and multiple sclerosis.
|
25989711 |
2015 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We analysed whether SNPs in the IRF5, IRF8 and GPC5 genes are associated with clinical disease activity in MS patients beginning de novo treatment with IFN-β.
|
24943672 |
2014 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In summary, IRF8 rs17445836G is associated with human autoimmune disease characterized by low-type I IFN levels, and this may have pharmacogenetic relevance as type I IFN is modulated in SLE and MS.
|
23965942 |
2013 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, there was no association of IRF8 polymorphisms with IDD, including MS and NMO.
|
22994200 |
2013 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, genetic variation in the IRF8 gene has been associated with SLE and multiple sclerosis, and studies support an impact of IRF8 genotype on the IFN-α pathway.
|
21575916 |
2011 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Variants in TNFRSF1A and in the vicinity of IRF8 were confirmed to be associated in these independent cohorts, which supports the role of these loci in etiology of multiple sclerosis.
|
21552549 |
2011 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
TNFRSF1A, CD6 and IRF8, as novel risk factors for multiple sclerosis with genome-wide level of significance.
|
20430450 |
2010 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
We also report that the susceptibility allele near IRF8, which encodes a transcription factor known to function in type I interferon signaling, is associated with higher mRNA expression of interferon-response pathway genes in subjects with MS.
|
19525953 |
2009 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We also report that the susceptibility allele near IRF8, which encodes a transcription factor known to function in type I interferon signaling, is associated with higher mRNA expression of interferon-response pathway genes in subjects with MS.
|
19525953 |
2009 |