IDE, insulin degrading enzyme, 3416

N. diseases: 71; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2931689
Disease: Dystrophia myotonica 2
Dystrophia myotonica 2
0.050 AlteredExpression disease BEFREE To contribute in the understanding of IDE's role in glucose metabolism, we analyzed IDE protein level in pancreatic islets from two hyperinsulinemic mouse models, db/db and high-fat diet (HFD) mice, as well as in human islets from DM2 patients treated with oral hypoglycemic agents (OHAs) or insulin. 29726577 2018
CUI: C2931689
Disease: Dystrophia myotonica 2
Dystrophia myotonica 2
0.050 Biomarker disease BEFREE Using dIde(KO) as a model, further investigations into the biological functions of IDE and its role in the pathogenesis of DM2 and AD can be made. 20493190 2010
CUI: C2931689
Disease: Dystrophia myotonica 2
Dystrophia myotonica 2
0.050 AlteredExpression disease BEFREE These results suggest that PPARgamma transcriptionally induces IDE expression which provides a novel mechanism for the use of PPARgamma agonists in both DM2 and AD therapies. 19383491 2009
CUI: C2931689
Disease: Dystrophia myotonica 2
Dystrophia myotonica 2
0.050 GeneticVariation disease BEFREE We conclude that naturally occurring, partial loss-of-function mutations in IDE sufficient to cause DM2 also impair neuronal regulation of Abeta levels, but the brain can apparently compensate for the partial deficit during the life span of the rat. 15039230 2004
CUI: C2931689
Disease: Dystrophia myotonica 2
Dystrophia myotonica 2
0.050 Biomarker disease BEFREE Two substrates of insulin-degrading enzyme (IDE), amyloid beta-protein (Abeta) and insulin, are critically important in the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes mellitus (DM2), respectively. 12634421 2003