IFNA1, interferon alpha 1, 3439

N. diseases: 662; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.330 Biomarker disease BEFREE These results offer a rationale for targeting of IFN/STAT signaling and for the stratification of CRC patients. 30724425 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.330 AlteredExpression disease BEFREE IFITM3, an IFN-inducible gene, is overexpressed in human colorectal cancer. 21531817 2011
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.330 Therapeutic disease CTD_human In an effort to improve the therapeutic effect of a MAb-based regimen in colorectal carcinoma (CRC) patients, the effects of a combination of alpha-interferon (alpha-IFN), 5-fluorouracil (5-FU), granulocyte-macrophage colony-stimulating factor (GM-CSF) and mouse MAb17-1A was evaluated in 27 patients with metastatic disease. alpha-IFN was given s.c. once daily for 5 consecutive days and at days 4 and 5, 5-FU was administered as a daily i.v. bolus injection. 15289873 2004
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.330 Biomarker disease BEFREE This finding provides an experimental basis for possible clinical therapy using retrovirus-mediated IFN-alpha gene transfer alone or in combination with other chemotherapeutic drugs for treatment of colorectal cancer. 10202238 1999