IFNA1, interferon alpha 1, 3439

N. diseases: 662; N. variants: 6
Disease: Fibrosis, Liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.380 Biomarker disease BEFREE Sessions included: IFN-λ Biology, Therapy and Genetic Variation; IFN-λ and Hepatitis C Virus Infection; IFN-λ in Other Infections; and IFN-λ-Hepatic Fibrosis and Cancer. 30998425 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.380 Biomarker disease BEFREE Antibody-mediated blockade of IFN-receptor or IL-10-receptor signalling reconstituted antibacterial immunity and prevented infection-associated mortality in mice with liver fibrosis. 27432540 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.380 Biomarker disease BEFREE The aim of this study is to improve the limitations of IFN-α including insufficient drug concentration for the target cells and side-effects causing serious concerns in treatment of hepatic fibrosis. 27928957 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.380 Biomarker disease BEFREE In this study, we examined the transcriptional profiling of type I IFN related genes in HCV-chronically infected patients with varying degrees of liver fibrosis. 27135246 2016
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.380 GeneticVariation disease BEFREE We examined the relationship between IFN-λ genotypes and significant liver fibrosis in HIV-HCV coinfection. 26984148 2016
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.380 Biomarker disease BEFREE The influence on race/ethnicity, baseline viremia, type of Peg-IFN, ribavirin dosage, and significant hepatic fibrosis on the results was evaluated. 23187978 2013
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.380 Biomarker disease BEFREE SD during HCV treatment (with Peg-IFN and ribavirin) for liver fibrosis was significant, as 24 (70.6%) out of 34 (100%) of HCV patients had advanced fibrosis but only 20 (32.3%) out of 62 (100%) patients had early fibrosis and were sexually affected (P = 0.01). 22064340 2012
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.380 Therapeutic disease CTD_human Dual therapeutic effects of interferon-alpha gene therapy in a rat hepatocellular carcinoma model with liver cirrhosis. 18665156 2008
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.380 GeneticVariation disease BEFREE To assess the influence of liver fibrosis on the outcome of anti-HCV therapy, all patients with genotype 3a hepatitis C who were naive to IFN-based therapies, and received RBV combined with standard IFN or pegylated IFN-(alpha2b (peg-IFN-alpha2b) as standard of care for their disease, were investigated at our centre. 17310824 2006