IRGM, immunity related GTPase M, 345611

N. diseases: 57; N. variants: 13
Disease: Encephalomyelitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.020 Biomarker disease BEFREE Here, we showed that the immunity-related GTPase family member 1 (Irgm1), also known as LRG-47, was expressed in M1 macrophages of draining lymph nodes (dLNs) from C57BL/6 mice with early EAE, and the IRGM1 heterozygote substantially reduced M1 macrophage accumulation in dLNs and spleen of the primary EAE stage. 27443879 2017
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.020 Biomarker disease BEFREE Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells. 20056715 2010