IFNG, interferon gamma, 3458

N. diseases: 1519; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease
0.400 Biomarker disease BEFREE Furthermore, baricitinib (an inhibitor of Janus kinases 1 and 2 (JAK1/JAK2) downstream of IFNγR/IL6R) completely prevented GvHD; expanded regulatory T cells by preserving JAK3-STAT5 signaling; downregulated CXCR3 and helper T cells 1 and 2 while preserving allogeneic antigen-presenting cell-stimulated T-cell proliferation; and suppressed the expression of major histocompatibility complex II (I-Ad), CD80/86, and PD-L1 on host antigen-presenting cells. 29691471 2018
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease
0.400 Biomarker disease BEFREE The P2X7 receptor antagonist Brilliant Blue G reduces serum human interferon-γ in a humanized mouse model of graft-versus-host disease. 28665482 2017
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease
0.400 Biomarker disease BEFREE In conclusion, the dynamics of IL-8 and IFN-γ in GVHD patients after PTCy was different from previously reported after conventional prophylaxis. 28898706 2017
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease
0.400 Biomarker disease BEFREE Thus, allogeneic Th1 CD4(+) cells generated during GVHD traffic to hematopoietic sites and induce bone marrow failure via IFNγ-mediated toxicity. 23523972 2013
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease
0.400 Biomarker disease CTD_human Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17. 22077062 2012
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease
0.400 AlteredExpression disease BEFREE Rosiglitazone inhibited GVHD-induced increases in serum levels of tumor necrosis factor-alpha, interferon-gamma, interleukin (IL)-6, and IL-12, and the GVHD-induced decreases in transforming growth factor-beta and IL-10. 22982856 2012
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease
0.400 Biomarker disease BEFREE Proinflammatory cytokines released by host tissues during conditioning treatment and interferon gamma released from donor T cells play a major role in acute graft-versus-host disease (GVHD). 12394168 2002
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease
0.400 AlteredExpression disease BEFREE The ability of PBMCs to lyse autologous PHA-blasts and T47D tumor cells exhibited an identical temporal relationship with expression of IL-10 and IFN-gamma during autologous GVHD. 12239181 2002
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease
0.400 Biomarker disease LHGDN Cytokine and chemokine profiles in autologous graft-versus-host disease (GVHD): interleukin 10 and interferon gamma may be critical mediators for the development of autologous GVHD. 12239181 2002
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease
0.400 GeneticVariation disease BEFREE Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation. 11520812 2001
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease
0.400 Biomarker disease BEFREE In the current study, we used reverse transcription (RT) polymerase chain reaction (PCR) to explore the mRNA expression of candidate inflammatory cytokines IL-1 alpha, IL-2, IL-4, IL-6, TNF-alpha, and interferon-gamma (IFN-gamma) in peripheral blood mononuclear cells (PBMC) and skin biopsies of allogeneic BMT patients with GVHD and controls. 7652763 1995
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease
0.400 AlteredExpression disease BEFREE IL-2 expression was not detected at all and interferon-gamma expression was not much changed during GVHD. 8136279 1993