|
Hepatitis
|
0.400 |
Biomarker
|
group |
BEFREE |
Simultaneous infection with S. venezuelensis and S. mansoni increased the liver concentration of IFN-γ and altered the Th2/Th1 balance, leading to great infiltration of neutrophils and macrophages, which resulted in larger liver inflammation and increased serum transaminase activity in comparison with mono-infected mice.
|
31783260 |
2020 |
|
Hepatitis
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Furthermore, global T-cells from the ENEG phase displayed a proinflammatory cytokine profile with upregulated IFN-γ and TNF-α expression, while this profile was suppressed in IT and IA patients.
|
31086463 |
2019 |
|
Hepatitis
|
0.400 |
Biomarker
|
group |
BEFREE |
Moreover, evodiamine administration evidently improved survival of mice with lethal bacterial infection, accompanied by increased production of IL-1β and interferon-γ, decreased bacterial load, and dampened liver inflammation.
|
30971927 |
2019 |
|
Hepatitis
|
0.400 |
Biomarker
|
group |
BEFREE |
Further, intrahepatic NK cells highly expressed interferon-gamma (IFN-γ), anti-IFN-γ neutralizing monoclonal antibody might obviously alleviate the hepatitis, and hepatocyte-specific IFN-γ overexpression promoted HCC.
|
30329167 |
2019 |
|
Hepatitis
|
0.400 |
Biomarker
|
group |
BEFREE |
Our study suggests that CD24 deficiency confers hepatoprotection by decreasing CD4<sup>+</sup> T-cell-dependent IFN-γ production in vivo, which suggests that CD24 might be a potential target molecule for reducing clinical hepatitis.
|
28065940 |
2018 |
|
Hepatitis
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Out data showed that liver inflammation induces IFN-γ expression, which then downregulates expression of the let-7a cluster through IRF-1 in colorectal cancer cells.
|
29695839 |
2018 |
|
Hepatitis
|
0.400 |
Biomarker
|
group |
BEFREE |
Interferon gamma (IFNγ)-producing T cells are associated with resolution; in contrast, interleukin-17 (IL-17)-producing T cells are linked to exacerbation of liver inflammation and injury.
|
30016182 |
2018 |
|
Hepatitis
|
0.400 |
Biomarker
|
group |
BEFREE |
Mouse MSCs (mMSCs) significantly reduced Con A- and α-GalCer-mediated hepatitis in C57Bl/6 mice, as demonstrated by histopathological and biochemical analysis, attenuated the influx of inflammatory [T-bet<sup>+</sup> , tumour necrosis factor-α (TNF-α), interferon-γ (IFN-γ)-producing and GATA3<sup>+</sup> , interleukin-4 (IL-4)-producing] liver NKT cells and downregulated TNF-α, IFN-γ and IL-4 levels in the sera.
|
28488390 |
2018 |
|
Hepatitis
|
0.400 |
Biomarker
|
group |
BEFREE |
In summary, our results demonstrated that γδ T cells played a protective role in restraining Con A-induced hepatitis by inhibiting IFN-γ production from CD4<sup>+</sup> T cells and are indispensable for IL-23-mediated protection against Con A-induced hepatitis in HBs-Tg mice.
|
28092402 |
2017 |
|
Hepatitis
|
0.400 |
Biomarker
|
group |
BEFREE |
Furthermore, we determined that NK T cells were the target of DC-derived IL-12, and NK T cells contributed to liver inflammation and injury through production of IFN-γ.
|
27891589 |
2017 |
|
Hepatitis
|
0.400 |
Biomarker
|
group |
BEFREE |
Interestingly, while TRAIL administration did not induce hepatitis in Ripk1 <sup>LPC-KO</sup> mice or in their WT counterparts, its combination with IFN-γ only induced TNF-α dependent apoptosis in the Ripk1 <sup>LPC-KO</sup> mice.
|
28835677 |
2017 |
|
Hepatitis
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The evidence suggests that the IFN-γ +874T/A polymorphism increases the risk of hepatitis virus-related diseases, especially in Asians and HBV-related diseases.
|
25939029 |
2015 |
|
Hepatitis
|
0.400 |
Biomarker
|
group |
BEFREE |
IL-27 regulated CXCR3 ligand expression in IFNγ-dependent manner during acute hepatitis suggesting a complementary role of IL-27 and IFNγ to moderate liver inflammation via regulation of CXCR3 ligands.
|
26199110 |
2015 |
|
Hepatitis
|
0.400 |
Biomarker
|
group |
BEFREE |
JUNB/AP-1 controls IFN-γ during inflammatory liver disease.
|
24200694 |
2013 |
|
Hepatitis
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Liver biopsies were performed on 20 chronically HBV-infected (15 HBeAg-positive and 5 HBeAg-negative) patients to assess liver inflammation/fibrosis, and mRNA levels of furin, IL-10, IL-12β, IFN-γ, PD-1, and PD-L1 were assessed by quantitative real-time PCR.
|
22634051 |
2012 |
|
Hepatitis
|
0.400 |
GeneticVariation
|
group |
BEFREE |
There was no difference in the HBV DNA levels during hepatitis flares between patients with genotypes B and C. Patients with genotype B had a significantly higher number of IFN-gamma producing cells [with hepatitis B core antigen (HBcAg) stimulation] and lower number of IL-10 producing cells (with HBcAg and HBeAg stimulation) compared with patients with genotype C (P = 0.011, =0.043, <0.001 respectively).
|
17381719 |
2007 |
|
Hepatitis
|
0.400 |
Biomarker
|
group |
BEFREE |
Some models of experimentally induced hepatitis point to a role of interferon-gamma (IFN-gamma) secreted by liver-infiltrating peripheral blood lymphocytes (PBMC) in mediating hepatocellular injury.
|
8884741 |
1996 |
|
Hepatitis
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These results indicate that IFN-gamma is the main cytokine trigger for ICAM-1 expression on HepG2 cells, suggesting that in areas of liver inflammation this adhesion molecule is up-regulated on hepatocytes by locally released IFN-gamma.
|
1346374 |
1992 |
|
Hepatitis
|
0.400 |
Biomarker
|
group |
CTD_human |
Hyponatremia and other toxic effects during a phase I trial of recombinant human gamma interferon and vinblastine.
|
3091246 |
1986 |