|
HIV Infections
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our findings indicate significant association of pro-inflammatory (IL2, IFN-γ, TNF-α) and anti-inflammatory cytokine gene variants (IL4, IL10) with the risk to acquire the HIV infection and development of AIDS related illness in Indian population.
|
31173933 |
2019 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
However, CD3<sup>+</sup>CD20<sup>+</sup> T cells may also play a protective role in ovarian cancer and HIV infection for their strong propensity to IFN-γ production.
|
30639700 |
2019 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
"Tuberculosis in advanced HIV infection is associated with increased expression of IFNγ and its downstream targets".
|
29764370 |
2018 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
HIV infection in ART-naïve women was associated with elevated breast milk levels of IP-10 and MIG, which areTh1-related cytokines induced by IFN-γ.
|
30359283 |
2018 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
As a result, CD4+ T cells generally lack effector functions in LNs, including cytolytic capacity and IFNγ and β-chemokine expression, even in HIV elite controllers and during acute/early HIV infection.
|
29652923 |
2018 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Interferon-gamma (IFN-γ)-inducible protein-10 (IP-10), soluble (s) CD163 and sCD14 play an important role in the pathogenesis of HCV and HIV infection and are involved in inflammation and liver fibrosis.
|
28578937 |
2017 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
We found 1) a constitutively lower frequency of IL-2+ and IFN-γ+ T cells in the CHR group compared with the HIV, CO and healthy groups; 2) a suppressive activity of soluble T. cruzi antigen, which down-regulated IL-2+CD4+ and IFN-γ+CD4+ phenotypes, notably in the healthy group; 3) a down-regulation of inflammatory cytokines on CD8+ T cells in the indeterminate form of Chagas disease; and 4) a significant increase in IL-10+CD8+ cells distinguishing the indeterminate form from the cardiac/digestive form of Chagas disease, even in the presence of HIV infection.
|
29236910 |
2017 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
In multivariate analysis, higher IFN-γ concentrations were associated with human immunodeficiency virus infection (OR 1.3, 95%CI 0.51-2.1, P = 0.001), and inversely associated with moderate or severe food insecurity (OR -1.6, 95%CI -2.9 to -0.27, P = 0.02) and the number of adults in the household (OR -0.08, 95%CI -0.16 to -0.01, P = 0.03).
|
28633705 |
2017 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
We demonstrate for perinatally HIV-infected children and adolescents receiving combined antiretroviral therapy and in good clinical status with respect to HIV disease that high concentrations of interferon-gamma-inducible protein 10 associate with increased exhausted memory B cells.
|
28419006 |
2017 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Systems serology analyses implicated a broader range of Ab-dependent functions in protection from HIV infection, including but not limited to ADCC and Ab-dependent NK cell activation (ADNKA) for secretion of IFN-γ and CCL4 and expression of the degranulation marker CD107a.
|
28883824 |
2017 |
|
HIV Infections
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Thus, a combination of genetic variations in IFN-γ and IL-10 cytokine genes in a single host associate with HIV disease progression and may help clinicians to better manage the HIV disease if known earlier.
|
26579633 |
2016 |
|
HIV Infections
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Subset analyses of individuals with latent Mtb infection or without human immunodeficiency virus infection yielded higher heritability estimates, suggesting 10-30% of variation in IFN-γ is caused by a shared environment.
|
23629934 |
2013 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
HIV-specific CD8 T cells in acute/early HIV infection secreted less IFN-γ but were more cytotoxic than their counterparts in chronic infection.
|
22955926 |
2012 |
|
HIV Infections
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Because IFN-gamma enhances IgG2 production, and IgG2 antibodies to HIV antigens and the 'high-affinity' polymorphism of FcgammaRIIa (the major Fc receptor for IgG2) have been associated with a favourable outcome of HIV infection, we examined the association of IgG2 antibodies to HIV p24 and 'high-affinity' polymorphisms of FcgammaRIIa with control of HIV replication in these patients.
|
20634666 |
2010 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
LHGDN |
Dissociated production of perforin, granzyme B, and IFN-gamma by HIV-specific CD8(+) cells in HIV infection.
|
18275349 |
2008 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels.
|
17262717 |
2007 |
|
HIV Infections
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We measured T cell responsiveness by lymphoproliferation and interferon-gamma ELISPOT in a large cohort of HCV-infected individuals with and without HIV infection.
|
17194190 |
2006 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
CTD_human |
Persistent alterations in T-cell repertoire, cytokine and chemokine receptor gene expression after 1 year of highly active antiretroviral therapy.
|
10202824 |
1999 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Within individuals, CD8 T cells showed the highest IFN-gamma expression regardless of HIV status, which suggests that HIV infection enhances the IFN-gamma gene expression in CD8 T cells rather than inducing a shift to and/or increasing expression of IFN-gamma mRNA in other cell types.
|
9184702 |
1997 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Increased levels of interferon-gamma (IFN-gamma), IL-4 and transforming growth factor-beta (TGF-beta) mRNA expressing blood mononuclear cells in human HIV infection.
|
8149667 |
1994 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Increased expression of IFN-gamma genes in CD4 T cells, however, indicates that these cells may be responsible for substantial amounts of circulating IFN-gamma that occur in HIV infection.
|
8409454 |
1993 |
|
HIV Infections
|
0.400 |
GeneticVariation
|
group |
BEFREE |
No evidence was obtained suggesting abnormal regulation of the TCGF or of the IFN-gamma gene consequent to HTLV-III infection.
|
3001715 |
1985 |