|
Leishmaniasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of CCR7 not only increased expression levels of IL-12 and IFN-γ but also activated the JAK-STAT signaling pathway to affect the leishmaniasis progression.
|
30584667 |
2019 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Leishmania infantum-specific IFN-γ production in stimulated blood from cats living in areas where canine leishmaniosis is endemic.
|
30909952 |
2019 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Finally, Group 3 included 44 dogs with clinical leishmaniosis (IFN-γ producers, n = 23; and IFN-γ non-producers, n = 21) that were negative to highly positive to L. infantum-specific antibodies.
|
30909975 |
2019 |
|
Leishmaniasis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IFNG variant rs2069705 seems to be a genetic modifier of clinical outcome of Leishmania infection; individuals with the H1 haplotype, associated with low levels of IFN-γ, have a 60% risk of developing CL.
|
31722386 |
2019 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Both antigen and parasite-specific CD4<sup>+</sup> T and CD8<sup>+</sup> T cells contributed to the IFN-γ production indicating that both subtypes contribute to the resistance to infection and correlated with robust nitrite generation, critical in controlling Leishmania infection.
|
30173073 |
2018 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Th1-type cytokine profile (presence of IFN-γ and absence of IL-10) suggests the potentiality of the cocktail of epitope as a subunit vaccine against leishmaniasis.
|
28585770 |
2018 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The main objective of this study was to investigate and compare the effect of a TLR2 agonist (TLR2a) alone or in combination with L. infantum antigen (LSA) on ex vivo whole blood cytokine production from healthy seronegative IFN-γ non-producer dogs from an area of low in canine leishmaniosis endemicity (n = 11); sick seropositive dogs with low production of IFN-γ (n = 17) and healthy seronegative or low positive Ibizan hounds with a predominant IFN-γ production (n = 21) from a highly endemic area.
|
28288677 |
2017 |
|
Leishmaniasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It seems that appropriate levels of IFN-γ, as well as IL-17a and CXCL-11, contribute to the control of Leishmania infection.
|
28168727 |
2017 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent findings have demonstrated the suitability of interferon-gamma-induced protein 10 (IP-10) or CXCL-10 as an immunotherapy tool in treatment of leishmaniasis.
|
28833211 |
2017 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Control of Leishmania infection is mediated by Th1 (IFNγ-producing) CD4+ T cells, which activate macrophages to produce nitric oxide and kill intracellular parasites.
|
28103263 |
2017 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity.
|
29091132 |
2017 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This finding demonstrates the importance of IFN-γ immunity in the control of leishmaniasis.
|
27873456 |
2017 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The immunopathogenesis of CL ulcer is associated with high interferon-γ and tumor necrosis factor (TNF) production.
|
28500815 |
2017 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The redirection of the immune response elicited against the LiPABP family (from IL-10 towards IFN-γ mediated responses) by genetic vaccination was able to induce a partial protection against the development of the disease in a highly susceptible murine model of leishmaniasis.
|
25955652 |
2015 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Seven L. (V.) braziliensis isolates from patients with different clinical forms of leishmaniasis were expanded in interferon-γ knockout mice to obtain amastigotes and in culture to get promastigotes.
|
24575815 |
2014 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Leishmaniasis is a parasitic disease affecting ∼12 million people.Control of infection (e.g. in C57BL/6 mice) results from IL-12-dependent production of IFNγ by Th1/Tc1 cells.
|
20955202 |
2011 |
|
Leishmaniasis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Despite this, IFNG +874T/A SNP could be involved in the pathogenesis of leishmaniasis by influencing the amount of cytokine released by CL patients, although it could not prevent disease development.
|
17456233 |
2007 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Circulating nitric oxide and C-reactive protein levels in Indian kala azar patients: correlation with clinical outcome.
|
17218153 |
2007 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Elevated levels of interferon-gamma, interleukin-10, and interleukin-6 during active disease in Indian kala azar.
|
16540374 |
2006 |
|
Leishmaniasis
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Balance of IL-10 and interferon-gamma plasma levels in human visceral leishmaniasis: implications in the pathogenesis.
|
16364177 |
2005 |
|
Leishmaniasis
|
0.400 |
Biomarker
|
disease |
LHGDN |
Up-regulation of Th1-type responses in mucosal leishmaniasis patients.
|
12438348 |
2002 |
|
Leishmaniasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Interferon-gamma (IFNgamma), a cytokine that participates in the activation of macrophages and the killing of intercellular parasites, induces healing of leishmaniasis.
|
12142611 |
2002 |