Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Parkinson disease patients score lower on Hospital-associated Anxiety and Depression Scale after supplementing blackcurrant anthocyanins (BCA), which may be associated with IGF-1 function.
|
29865234 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Outcomes included changes of metabolic parameters (insulin, glucose, insulin resistance, insulin-like growth factor-1, brain-derived neurotropic factor, lipids, liver enzymes, hemoglobin A1c) and coagulation markers; bioelectrical impedance analysis; body mass index; abdominal girth; blood pressure; general quality of life (five-item World Health Organization Well-Being Index [WHO-5] questionnaire), as well as mood and anxiety (Hospital Anxiety and Depression Scale [HADS], Profile of Mood States, Flourishing-Scale, visual analog scale, Likert scales).
|
29031771 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Further, administration of the IGF-1 receptor antagonist JB-1 blocked the antidepressive-like activity of the insulin and IGF-1, indicating a strong relationship between insulin, IGF-1 and depression.
|
30278200 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
IGF-1 defends against chronic-stress induced depression in rat models of chronic unpredictable mild stress through the PI3K/Akt/FoxO3a pathway.
|
30063009 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Altogether, our findings suggest a novel 5HT3R-IGF1 mechanism that is distinct from fluoxetine-induced responses and that provides a new therapeutic target for depression, especially bringing significant benefits for SSRI-resistant depressed patients.
|
28439104 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Inflammation and trophic factors (brain-derived neurotrophic factor [BDNF], vascular endothelial growth factor, glial cell line-derived neurotrophic factor, and insulin-like growth factor-1) are associated with depression in the general population.
|
29787856 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The depression distribution across the IGF-1 quartiles ranged between 61.4% (first quartile) and 8.9% (fourth quartile).
|
28833493 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alpha1-antitrypsin (A1AT), FAS, Heparin-binding EGF-like Growth Factor (HB-EGF), Insulin-like Growth Factor-1 (IGF-1), Luteinizing Hormone (LH), Macrophage Inflammatory Protein type 1 alpha (MIP-1α), Resitin, S100b, Tissue Inhibitor of Metalloproteinase type 1 (TIMP-1), and Vascular Cell Adhesion Molecule type 1 (VCAM-1) each were partial mediators of depression's association with δ.
|
28594820 |
2017 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
159 individuals including PSD, stroke without depression (Non-PSD), major depressive disorder (MDD) and normal control groups were recruited and examined the protein and mRNA expression levels of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptors (VEGFR2), placental growth factor (PIGF), insulin-like growth factor (IGF-1) and insulin-like growth factor receptors (IGF-1R).
|
27527872 |
2016 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In vivo, the ablation of Casp6 results in a partial rescue of body weight gain, normalized IGF-1 levels, a reversal of the depression-like phenotype and decreased HTT levels.
|
25583186 |
2015 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In our study, elevated IGF-I levels were significantly associated with depression and impaired treatment response.
|
25836355 |
2015 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We demonstrated that prenatal stress leads to depression-like behavior, decreased IGF-1, increased IL-1β, TNF-α and IFN-γ release and disturbed SOCS-1, SOCS-2 and SOCS-3 expression in the hippocampus and frontal cortex of adult offspring.
|
25151093 |
2014 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Deiodinase type 1 (D1) polymorphisms particularly show moderate-to-strong relationships with thyroid hormone parameters, IGF1 production, and risk for depression.
|
24878678 |
2014 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Deiodinase type 1 (D1) polymorphisms particularly show moderate-to-strong relationships with thyroid hormone parameters, IGF1 production, and risk for depression.
|
24878678 |
2014 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
When administered before or after LPS, IGF-I and GPE abrogated the LPS response; attenuating induction of depression-like behaviors and blocking preexistent depression-like behaviors.
|
22189158 |
2011 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Our study supports the hypothesis that the natural IGF-1 decline in aging humans may contribute to geriatric depression.
|
21524689 |
2011 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Growth factors in the brain are important to depression and it's treatment and we assessed the ability of peripherally administered insulin-like growth factor-I (IGF-I) to influence behavior related to depression.
|
19056428 |
2009 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Studies in vitro and in vivo, using normal and transgenic animals, have led to the hypothesis that, in the adult brain, IGF-I not only acts as a trophic factor, but also as a neuromodulator of some higher brain functions, such as long-term potentiation and depression.
|
8938649 |
1996 |