IGF1, insulin like growth factor 1, 3479

N. diseases: 1206; N. variants: 36
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.360 Biomarker disease BEFREE Fifty-one consecutive patients of AKI following vasculotoxic snake bite were evaluated for various clinical/biochemical parameters (including Free T4, TSH, Cortisol, ACTH, total testosterone, FSH, LH, prolactin, and IGF-1). 31556012 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.360 AlteredExpression disease BEFREE Thus, our study indicated that enhancement of UC-MSCs bioactivities with IGF-1 overexpression could increase the UC-MSCs therapeutic potential and further developed a new therapeutic strategy for the treatment of AKI. 26830766 2016
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.360 Biomarker disease BEFREE Our preliminary findings suggest that IGF-I is locally produced in the kidney during the recovery period of ARF and might play roles in the repair processes, and extend the experimental observations in animal models into human pathophysiology. 10499309 1999
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.360 Biomarker disease BEFREE Exogenous administration of some growth factors, such as IGF-I, EGF and HGF, accelerates recovery of renal function in experimental acute renal failure (ARF). 9541273 1998
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.360 AlteredExpression disease BEFREE IGF-IR mRNA was decreased in renal cortex and medulla of both ARF groups and was not detected in liver in any group. 9767523 1998
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.360 Biomarker disease BEFREE Further studies to determine the role of IGF-I as a therapeutic agent for acute renal failure and its utility as a medical therapy for chronic renal insufficiency are required. 9255221 1997
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.360 Therapeutic disease CTD_human Solution hybridization RNAase protection assays showed that renal IGF-1 mRNA, IGF-1 receptor (IGF-1R) mRNA, and IGF-binding protein-1 (IGFBP-1) mRNA were unaffected by exogenous IGF-1, but this treatment significantly increased renal IGF-1 in ARF rats compared with normal rats and ARF rats not receiving IGF-1. 7540432 1995