IGF1, insulin like growth factor 1, 3479

N. diseases: 1206; N. variants: 36
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 Biomarker disease BEFREE IGF-1R/β-catenin signaling axis is involved in type 2 diabetic osteoporosis. 31489803 2020
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 AlteredExpression disease BEFREE We evaluated the impact of hormonal alterations, with special focus on low T3 and IGF-1 levels, on antioxidant systems as a link with osteoporosis in FHA. 30847871 2019
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 AlteredExpression disease BEFREE Furthermore, GFJ treatment before and after prednisolone-induced osteoporosis decreased plasma alkaline phosphatase and tartrate-resistant acid phosphatase activities and increased the level of insulin-like growth factor 1. 31147813 2019
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 AlteredExpression disease BEFREE In conclusion, glucocorticoid instead of caffeine inhibits bone IGF1 expression via glucocorticoid receptor and CCAAT and enhancer binding protein α and mediates the PCE-induced bone dysplasia and bone mass reduction in offspring fetal rats, which may contribute to osteoporosis susceptibility in adulthood. 30273601 2018
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 Biomarker disease BEFREE The relations between IGF-I and bone mineral density (BMD) or osteoporosis have been assessed in previous studies but whether the associations are sex-specific remains uncertain. 29498081 2018
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 GeneticVariation disease BEFREE The present systematic review and meta-analysis was performed to appraise and synthesize the existing evidence, so as to provide a more precise and reliable association between polymorphisms in IGF-1 gene and osteoporosis. 29747606 2018
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 Biomarker disease BEFREE Insulin-like growth factor 1 (IGF-1) has been associated with osteoporosis, cardiovascular disease, cancer, neurodegenerative diseases, and mortality in middle and older aged adults. 29474865 2018
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 GeneticVariation disease BEFREE By conditional regression analysis, we found that the IGF-1 rs2288377 and rs972936 gene polymorphisms were not associated with the risk of osteoporosis (P < 0.05). 26600491 2015
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 GeneticVariation disease BEFREE Our study suggests that TT genotype and CT+TT genotype of IGF-I rs35767 were associated with risk of osteoporosis and BMD levels. 26191288 2015
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 GeneticVariation disease BEFREE In conclusion, our results sug-gest that the TT genotype of IGF-I rs35767 was associated with an in-creased risk of osteoporosis, suggesting that this polymorphism can be used as a predictive factor for osteoporosis risk. 26214445 2015
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 Biomarker disease RGD Etiopathogenesis of hepatic osteodystrophy in Wistar rats with cholestatic liver disease. 19424739 2009
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 GeneticVariation disease LHGDN To find out which of the following parameters-serum levels of insulin-like growth factor 1 (IGF-1), osteoprotegerin (OPG), leptin, osteocalcin (OC), and urinary excretion of N-terminal telopeptide of type I collagen (NTx), can be used as an early marker for osteopenia/osteoporosis in women diagnosed by dual-energy X-ray absorptiometry (DXA), 282 premenopausal and 222 postmenopausal women aged 20-75 years were investigated by the measurement of bone mineral densities (BMDs) at lumbar spine (LS) and femoral neck (FN) by DXA, together with serum concentrations of IGF-1, OPG, leptin, OC, and urinary NTx. 18301972 2008
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 Therapeutic disease RGD Growth hormone treatment prevents osteoporosis in uremic rats. 17647196 2007
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 Biomarker disease BEFREE Molecular dissection of the IGF regulatory system and its signaling pathway in bone may reveal novel therapeutic targets for the treatment of osteoporosis. 16183214 2005
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 GeneticVariation disease BEFREE Insulin-like growth factor I (IGF-I) gene microsatellite repeat polymorphism was found to be associated with osteoporosis in some studies, and collagen-Ialpha1 (COLIA1) Sp1 s allele was associated with lower bone mineral density in primary biliary cirrhosis. 15256976 2004
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 AlteredExpression disease BEFREE However, the precise relationship between the expression of IGF-I in bone and skeletal homeostasis or pathological conditions such as osteoporosis, remains poorly defined. 15261847 2004
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 AlteredExpression disease BEFREE In the logistic regression model, the COLIA1 Sp1 polymorphism, S-25OHD, s-IGF-I and physical activity variables were independently associated with osteoporosis. 15592793 2004
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 Biomarker disease BEFREE Insulin-like growth factor I (IGF-I) is an attractive candidate gene for osteoporosis susceptibility, because IGF-I has marked effects on bone cells and has been implicated in the pathogenesis of osteoporosis. 10599704 1999
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 GeneticVariation disease BEFREE The present study showed that there was no association between the microsatellite polymorphism of IGF-I gene and BMD in Japanese postmenopausal women, but some possibility remains that the microsatellite polymorphism of IGF-I gene is useful to detect a kind of particular osteoporosis. 9744989 1998
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 Biomarker disease RGD Diabetic bone disease. Low turnover osteoporosis related to decreased IGF-I production. 1466160 1992
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 Biomarker disease HPO