IGF1, insulin like growth factor 1, 3479

N. diseases: 1206; N. variants: 36
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker group BEFREE IGF-1 elevation led to the accumulation of FOXO3A in the cytosol of prostate tumor cells and downregulation of its target gene Bim, which resulted in the apoptosis inhibition and prostate cancer overgrowth. 31312023 2019
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker group BEFREE Determination of the expression and localization of IL-6 and IGF-1Ec in prostate tumors was examined by qRT-PCR and by IHC. 30134795 2018
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker group BEFREE Detailed in vivo therapeutic efficacy studies, through the intratumoral delivery of MGF-<sup>198</sup>AuNPs, show the retention of over 80% of the injected dose (ID) in prostate tumors up to 24 h. By three weeks post treatment, tumor volumes of the treated group of animals showed an over 5 fold reduction as compared to the control saline group. 28440368 2017
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker group BEFREE Our findings suggest that increase in PSMA in prostate tumors contributes to progression by altering normal signal transduction pathways to drive PCa progression and that enhanced signaling through the IGF-1R/β<sub>1</sub> integrin axis may occur in other tumors. 28292957 2017
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker group CTD_human Genetic polymorphisms in IGF-I and IGFBP-3 are associated with prostate cancer in the Chinese population. 24586243 2014
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression group BEFREE IGF-IR expression positively correlates with PTEN and inversely correlates with NRP2 in prostate tumors. 22777769 2012
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression group BEFREE Common variants in the adiponectin gene were associated with prostate cancer risk, plasma adiponectin levels, and IR or IGF-IR expression in the prostate tumor. 21960694 2011
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression group BEFREE Similarly, IGF-I suppressed BMP4-induced transcription of the Id1, Id2, and Id3 genes that are crucially involved in prostate tumor progression through PI3K-dependent and mTORC1/2-dependent mechanisms. 21062988 2010
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker group CTD_human Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study. 19208208 2009
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker group RGD Characterization of SV-40 Tag rats as a model to study prostate cancer. 19171036 2009
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker group BEFREE In the present study, we investigated the role of insulin-like growth factor-I (IGF-I) in the regulation of ZEB1 during EMT associated with prostate tumor cell migration. 18381457 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 GeneticVariation group LHGDN Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels. 17911177 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 GeneticVariation group LHGDN Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer. 17096324 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker group LHGDN Influence of bicalutamide with or without tamoxifen or anastrozole on insulin-like growth factor 1 and binding proteins in prostate cancer patients. 16847815 2006
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker group CTD_human Insulin-like growth factor-I promotes migration in human androgen-independent prostate cancer cells via the alphavbeta3 integrin and PI3-K/Akt signaling. 16465378 2006
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker group LHGDN Expression analysis of peptide growth factors VEGF, FGF2, TGFB1, EGF and IGF1 in prostate cancer and benign prostatic hyperplasia. 16820871 2006
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression group BEFREE The novel serine/threonine kinase GS3955 was markedly up-regulated (greater than 40-fold) in C4-2, differentially regulated in LNCaP and C4-2 by insulin-like growth factor-1, and variably expressed in human prostate tumor specimens. 15311059 2004
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker group LHGDN Insulin-like growth factor I (IGF-I) and IGF binding protein-1 modulate prostate cancer cell growth and apoptosis: possible mediators for the effects of diet and exercise on cancer cell survival. 12746292 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression group LHGDN Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells. 12843187 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker group LHGDN Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer. 12122101 2002