Prostatic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
IGF-1 elevation led to the accumulation of FOXO3A in the cytosol of prostate tumor cells and downregulation of its target gene Bim, which resulted in the apoptosis inhibition and prostate cancer overgrowth.
|
31312023 |
2019 |
Prostatic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
Determination of the expression and localization of IL-6 and IGF-1Ec in prostate tumors was examined by qRT-PCR and by IHC.
|
30134795 |
2018 |
Prostatic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
Detailed in vivo therapeutic efficacy studies, through the intratumoral delivery of MGF-<sup>198</sup>AuNPs, show the retention of over 80% of the injected dose (ID) in prostate tumors up to 24 h. By three weeks post treatment, tumor volumes of the treated group of animals showed an over 5 fold reduction as compared to the control saline group.
|
28440368 |
2017 |
Prostatic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
Our findings suggest that increase in PSMA in prostate tumors contributes to progression by altering normal signal transduction pathways to drive PCa progression and that enhanced signaling through the IGF-1R/β<sub>1</sub> integrin axis may occur in other tumors.
|
28292957 |
2017 |
Prostatic Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Genetic polymorphisms in IGF-I and IGFBP-3 are associated with prostate cancer in the Chinese population.
|
24586243 |
2014 |
Prostatic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
IGF-IR expression positively correlates with PTEN and inversely correlates with NRP2 in prostate tumors.
|
22777769 |
2012 |
Prostatic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Common variants in the adiponectin gene were associated with prostate cancer risk, plasma adiponectin levels, and IR or IGF-IR expression in the prostate tumor.
|
21960694 |
2011 |
Prostatic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Similarly, IGF-I suppressed BMP4-induced transcription of the Id1, Id2, and Id3 genes that are crucially involved in prostate tumor progression through PI3K-dependent and mTORC1/2-dependent mechanisms.
|
21062988 |
2010 |
Prostatic Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study.
|
19208208 |
2009 |
Prostatic Neoplasms
|
0.600 |
Biomarker
|
group |
RGD |
Characterization of SV-40 Tag rats as a model to study prostate cancer.
|
19171036 |
2009 |
Prostatic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
In the present study, we investigated the role of insulin-like growth factor-I (IGF-I) in the regulation of ZEB1 during EMT associated with prostate tumor cell migration.
|
18381457 |
2008 |
Prostatic Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels.
|
17911177 |
2007 |
Prostatic Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer.
|
17096324 |
2007 |
Prostatic Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
Influence of bicalutamide with or without tamoxifen or anastrozole on insulin-like growth factor 1 and binding proteins in prostate cancer patients.
|
16847815 |
2006 |
Prostatic Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Insulin-like growth factor-I promotes migration in human androgen-independent prostate cancer cells via the alphavbeta3 integrin and PI3-K/Akt signaling.
|
16465378 |
2006 |
Prostatic Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
Expression analysis of peptide growth factors VEGF, FGF2, TGFB1, EGF and IGF1 in prostate cancer and benign prostatic hyperplasia.
|
16820871 |
2006 |
Prostatic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The novel serine/threonine kinase GS3955 was markedly up-regulated (greater than 40-fold) in C4-2, differentially regulated in LNCaP and C4-2 by insulin-like growth factor-1, and variably expressed in human prostate tumor specimens.
|
15311059 |
2004 |
Prostatic Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
Insulin-like growth factor I (IGF-I) and IGF binding protein-1 modulate prostate cancer cell growth and apoptosis: possible mediators for the effects of diet and exercise on cancer cell survival.
|
12746292 |
2003 |
Prostatic Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells.
|
12843187 |
2003 |
Prostatic Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer.
|
12122101 |
2002 |