APOE, apolipoprotein E, 348

N. diseases: 1049; N. variants: 62
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE We previously reported that varenicline aggravates atherosclerosis in apolipoprotein E knockout (ApoE KO) mice. 31771811 2020
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclerosis. 31634818 2020
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 GeneticVariation disease BEFREE Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice. 31599473 2020
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE We investigated the effect of such lipid-lowering interventions on atherosclerosis in APOE*3-Leiden.CETP mice, a well-established model for hyperlipidemia. 31843957 2020
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE Subjected to overexpressed GAS5, overexpressed EZH2, or downregulated ABCA1, the Apolipoprotein E (ApoE)<sup>-/-</sup> mice with atherosclerosis showed increased total cholesterol (TC), free cholesterol (FC), cholesterol ester (CE), low-density lipoprotein (LDL) levels, aortic plaque, and lipid accumulation, accompanied by reduced high-density lipoprotein (HDL) level and cholesterol outflow. 31830648 2020
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE Apolipoprotein E knockout (ApoE<sup>-/-</sup> ) mice fed a high-fat-diet (HFD) to establish AS model. 31232476 2020
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE Chronic OSM administration in APOE*3Leiden.CETP mice reduced atherosclerosis development. 31461490 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE Polydatin attenuates atherosclerosis in apolipoprotein E-deficient mice: Role of reverse cholesterol transport. 31085374 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE In the present study, we demonstrated the role of Plin5 in high-fat-diet-induced atherosclerosis in apolipoprotein E null (ApoE<sup>-/-</sup> ) mice. 31297870 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 AlteredExpression disease BEFREE Among them, 177 proteins were also differentially expressed in diabetic apolipoprotein E deficient (ApoE-/-STZ) mice, suggesting expression changes associated with atherosclerosis independent of the model used. 30826357 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)-/- mice. 31713591 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE Western blot and fluorescence-activated cell sorting analysis showed that Rheb expression was significantly increased in atherosclerotic lesions of atherosclerosis-prone (apoE<sup>-/-</sup> [apolipoprotein E deficient]) mice fed with Western diet. 31315433 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE Effects of atorvastatin and/or probucol on recovery of atherosclerosis in high-fat-diet-fed apolipoprotein E-deficient mice. 30551396 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE Mesenchymal stem cells (MSCs) show immunosuppressive activities and alleviate atherosclerosis (AS) formation in apolipoprotein E‑knockout (apoE‑KO) mice. 31364743 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE In addition, gypenosides (GP), a KLF14 activator, delayed the development of atherosclerosis in apolipoprotein E deficient (apoE<sup>-/-</sup>) mice. 31518965 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE For this purpose, 12-week old hyperlipidemic apolipoprotein E knockout mice were fed a Western-type diet for six weeks to induce both hepatic steatosis and atherosclerosis. 30776415 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE Overexpression of CTRP9 attenuates the development of atherosclerosis in apolipoprotein E-deficient mice. 30426302 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE Melatonin Inhibits in Vitro Smooth Muscle Cell Inflammation and Proliferation and Atherosclerosis in Apolipoprotein E-Deficient Mice. 30661353 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE 44 apolipoprotein E (ApoE)-/- 7 weeks old male rats were randomly divided into normal diet group (NC group) and AS model group (high-fat diet feeding). 31002155 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE In the present study, we used Apolipoprotein E-deficient (ApoE<sup>-/-</sup>) mice model and in vitro cell line of RAW264.7 to explore the mechanisms of ethanol extracts of Danlou tablet (EEDT) in treating atherosclerosis. 31181336 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE In conclusion, pre- and postnatal inflammation have additive and deleterious effects on the development of atherosclerosis in ApoE knockout mice. 31088858 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE In this study, we collected blood samples from patients of coronary artery diseases and apolipoprotein E (ApoE)<sup>-/-</sup> mice that were fed a Western diet for 12 wk to induce atherosclerosis and found that serum CTRP13 level was decreased. 30222079 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 AlteredExpression disease BEFREE Physical exercise inhibits atherosclerosis development by regulating the expression of neuropeptide Y in apolipoprotein E-deficient mice. 31605707 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE The effect of MALAT1 on atherosclerosis was determined in apolipoprotein E-deficient (Apoe<sup>-</sup><sup>/-</sup>) MALAT1-deficient (Malat1<sup>-/-</sup>) mice that were fed with a high-fat diet and by studying the regulation of MALAT1 in human plaques. 30586743 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE Allergic asthma aggravated atherosclerosis increases cholesterol biosynthesis and foam cell formation in apolipoprotein E-deficient mice. 31558320 2019