Coronary heart disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
The objective of the study was to explore whether APOE-containing HDL can attenuate the defective impact of cholesterol-overloaded HDL on the development of coronary heart disease (CHD) in humans.
|
29217413 |
2019 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Metabolic profile and ApoE4 genotype have effects on coronary heart disease.
|
31362877 |
2019 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The long-term consumption of a MedDiet modulates ppHTG through APOE genetic variants in CHD patients.
|
31166609 |
2019 |
Coronary heart disease
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
In men, we found that CHD patients had significantly lower levels of APOE methylation than non-CHD controls (P = 0.044).
|
30576806 |
2019 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
APOE polymorphism is associated with blood lipid and serum uric acid metabolism in hypertension or coronary heart disease in a Chinese population.
|
31559922 |
2019 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A Case-Control Study of the Association of the Polymorphisms of MTHFR and APOE with Risk Factors and the Severity of Coronary Artery Disease.
|
31163415 |
2019 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A further gender-based subgroup analysis revealed significant associations of APOE rs7259620 and PPAP2B rs72664392 with CHD in males (genotype: χ2=8.379, df=2, p=0.015; allele: χ2=5.190, df=1, p=0.023; recessive model: χ2=19.3, df=1, p<0.0001) and females (genotype: χ2=9.878, df=2, p=0.007), respectively.
|
29848931 |
2018 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In addition, our analyses suggested that genetic variations at the ANKS1A, COL4A2 and APOE loci previously found associated with coronary artery disease in the general population could have stronger effects in patients with type 1 diabetes.
|
29695241 |
2018 |
Coronary heart disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Therefore, ApoE4 is likely to be the bridge between AD and CHD, and may be a potentially promising therapeutic target.
|
29623835 |
2018 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In contrast, every SD unit increase in palmitic acid was related to an increased risk of all-cause stroke (HR, 1.58 [95% CI, 1.16-2.17]), ischemic stroke (HR, 1.76 [95% CI, 1.26-2.45]), and coronary heart disease (HR, 1.48 [95% CI, 1.09-2.01]), also in APOE-ε4 carriers only.
|
30571417 |
2018 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
No variables impacted cognitive or functional decline for men, whereas copies of APOE-ϵ4 and the CHD risk had no significant effects whatsoever.
|
29064737 |
2018 |
Coronary heart disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Human apolipoprotein E (ApoE) is associated with high cholesterol levels, coronary artery disease, and especially Alzheimer's disease.
|
29202360 |
2018 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans.
|
28727855 |
2017 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib.
|
28753643 |
2017 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Variations in genes involved in apolipoprotein E (APOE) production, the Wnt signalling pathway, and histone modification, as well as in the 1q21.1, 16p13.1-11, and 8p23.1 genetic loci, have been associated with CHD and NDDs and are important targets for future research.
|
29173597 |
2017 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, the AT04A anti-PCSK9 vaccine was evaluated for its therapeutic potential in ameliorating or even preventing coronary heart disease in the atherogenic APOE*3Leiden.CETP mouse model.
|
28637178 |
2017 |
Coronary heart disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
The Associations between Apolipoprotein E Gene Epsilon2/Epsilon3/Epsilon4 Polymorphisms and the Risk of Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus.
|
29311965 |
2017 |
Coronary heart disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
The apolipoprotein E (apoE) gene has been implicated in various conditions, most notably Alzheimer's disease and coronary artery disease.
|
28299413 |
2017 |
Coronary heart disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Immunoblot analysis showed that vinexin β expression is upregulated in the atherosclerotic lesions of both patients with coronary heart disease and hyperlipemic apolipoprotein E-deficient mice and is primarily localized in macrophages indicated by immunofluorescence staining.
|
28209562 |
2017 |
Coronary heart disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
APOE ε2 represents the first significant association for multiple subclinical atherosclerosis traits across multiple ethnicities, as well as clinical coronary heart disease.
|
27872105 |
2016 |
Coronary heart disease
|
0.700 |
Biomarker
|
disease |
RGD |
Establishment of a rat model with diet-induced coronary atherosclerosis.
|
28808185 |
2016 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Study of common variants of the apolipoprotein E and lipoprotein lipase genes in patients with coronary heart disease and variable body mass index.
|
26188224 |
2016 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In contrast to some previous studies, these results support the role of the APOE E4 allele as an independent risk factor for ischemic stroke and ischemic coronary heart disease among Greek patients.
|
27629735 |
2016 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that disruption of organization of large-scale networks may contribute to neurobehavioral dysfunction in adolescents with CHD and that this effect may interact with APOE genotype.
|
27547505 |
2016 |
Coronary heart disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ApoE gene polymorphism and its relationship with coronary artery disease in ethnic Kashmiri population.
|
26409839 |
2016 |