APOE, apolipoprotein E, 348

N. diseases: 1049; N. variants: 62
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 Biomarker disease BEFREE The objective of the study was to explore whether APOE-containing HDL can attenuate the defective impact of cholesterol-overloaded HDL on the development of coronary heart disease (CHD) in humans. 29217413 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease BEFREE Metabolic profile and ApoE4 genotype have effects on coronary heart disease. 31362877 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease BEFREE The long-term consumption of a MedDiet modulates ppHTG through APOE genetic variants in CHD patients. 31166609 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 PosttranslationalModification disease BEFREE In men, we found that CHD patients had significantly lower levels of APOE methylation than non-CHD controls (P = 0.044). 30576806 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease BEFREE APOE polymorphism is associated with blood lipid and serum uric acid metabolism in hypertension or coronary heart disease in a Chinese population. 31559922 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease BEFREE A Case-Control Study of the Association of the Polymorphisms of MTHFR and APOE with Risk Factors and the Severity of Coronary Artery Disease. 31163415 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease BEFREE A further gender-based subgroup analysis revealed significant associations of APOE rs7259620 and PPAP2B rs72664392 with CHD in males (genotype: χ2=8.379, df=2, p=0.015; allele: χ2=5.190, df=1, p=0.023; recessive model: χ2=19.3, df=1, p<0.0001) and females (genotype: χ2=9.878, df=2, p=0.007), respectively. 29848931 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease BEFREE In addition, our analyses suggested that genetic variations at the ANKS1A, COL4A2 and APOE loci previously found associated with coronary artery disease in the general population could have stronger effects in patients with type 1 diabetes. 29695241 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 Biomarker disease BEFREE Therefore, ApoE4 is likely to be the bridge between AD and CHD, and may be a potentially promising therapeutic target. 29623835 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease BEFREE In contrast, every SD unit increase in palmitic acid was related to an increased risk of all-cause stroke (HR, 1.58 [95% CI, 1.16-2.17]), ischemic stroke (HR, 1.76 [95% CI, 1.26-2.45]), and coronary heart disease (HR, 1.48 [95% CI, 1.09-2.01]), also in APOE-ε4 carriers only. 30571417 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease BEFREE No variables impacted cognitive or functional decline for men, whereas copies of APOE-ϵ4 and the CHD risk had no significant effects whatsoever. 29064737 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 Biomarker disease BEFREE Human apolipoprotein E (ApoE) is associated with high cholesterol levels, coronary artery disease, and especially Alzheimer's disease. 29202360 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease BEFREE Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans. 28727855 2017
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease GWASCAT Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib. 28753643 2017
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease BEFREE Variations in genes involved in apolipoprotein E (APOE) production, the Wnt signalling pathway, and histone modification, as well as in the 1q21.1, 16p13.1-11, and 8p23.1 genetic loci, have been associated with CHD and NDDs and are important targets for future research. 29173597 2017
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease BEFREE In this study, the AT04A anti-PCSK9 vaccine was evaluated for its therapeutic potential in ameliorating or even preventing coronary heart disease in the atherogenic APOE*3Leiden.CETP mouse model. 28637178 2017
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 Biomarker disease BEFREE The Associations between Apolipoprotein E Gene Epsilon2/Epsilon3/Epsilon4 Polymorphisms and the Risk of Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus. 29311965 2017
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 Biomarker disease BEFREE The apolipoprotein E (apoE) gene has been implicated in various conditions, most notably Alzheimer's disease and coronary artery disease. 28299413 2017
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 Biomarker disease BEFREE Immunoblot analysis showed that vinexin β expression is upregulated in the atherosclerotic lesions of both patients with coronary heart disease and hyperlipemic apolipoprotein E-deficient mice and is primarily localized in macrophages indicated by immunofluorescence staining. 28209562 2017
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 Biomarker disease BEFREE APOE ε2 represents the first significant association for multiple subclinical atherosclerosis traits across multiple ethnicities, as well as clinical coronary heart disease. 27872105 2016
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 Biomarker disease RGD Establishment of a rat model with diet-induced coronary atherosclerosis. 28808185 2016
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease BEFREE Study of common variants of the apolipoprotein E and lipoprotein lipase genes in patients with coronary heart disease and variable body mass index. 26188224 2016
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease BEFREE In contrast to some previous studies, these results support the role of the APOE E4 allele as an independent risk factor for ischemic stroke and ischemic coronary heart disease among Greek patients. 27629735 2016
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease BEFREE Our results suggest that disruption of organization of large-scale networks may contribute to neurobehavioral dysfunction in adolescents with CHD and that this effect may interact with APOE genotype. 27547505 2016
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.700 GeneticVariation disease BEFREE ApoE gene polymorphism and its relationship with coronary artery disease in ethnic Kashmiri population. 26409839 2016