Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Meanwhile, regardless of APOE4 status, AD dementia patients with hypertension had significantly lower Aβ deposition than those without hypertension.
|
30553154 |
2019 |
Hypertensive disease
|
0.700 |
PosttranslationalModification
|
group |
BEFREE |
Importantly, our results indicated a significant association between ApoE promoter methylation and ACI (OR = 16.146; 95% CI, 1.154-225.832; P* < .05; P*: adjusted for age, gender, carotid atherosclerotic plaque, hypertension, HDL-C, homocysteine, and folate) (Table 4).
|
30658954 |
2019 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Positive predictive factors were found in younger age (SMD = -0.345, 95% CI, -0.501 to -0.189), higher education level (SMD = 0.337, 95% CI, 0.117-0.558), no APOE ε4 allele (OR = 0.728, 95% CI, 0.575-0.922), no hypertension (OR = 0.826, 95% CI, 0.692-0.987), no stroke (OR = 0.696, 95% CI, 0.507-0.953), and higher Mini-Mental State Examination (MMSE) score (SMD = 0.707, 95% CI, 0.461-0.953).
|
31179580 |
2019 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
This review article will highlight the molecular mechanisms by which peri-menopause may influence the female brain vulnerability to AD and AD risk factors, such as hypertension and apolipoprotein E (APOE) genotype.
|
31551757 |
2019 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
In ApoE4+ women, CIMT was significantly higher in those with poor metabolic phenotype compared with healthy (p = 0.0003) and high blood pressure (p = 0.001) phenotypes.
|
31362877 |
2019 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
In men only, ApoE E4 associated with CVD (adjusted OR (aOR)=1.46, 95%CI 0.76, 2.80) and with 18-year mortality (adjusted HR (aHR) =1.47, 95%CI 0.95, 2.26), adjusting for age, ethnicity, physical activity, hypertension, diabetes, LDL-cholesterol, HDL-cholesterol, triglycerides and lipid-lowering medications.
|
31585002 |
2019 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Specifically, compared with normotensive women with the APOE e3/3 genotype, APOE e4 allele carriers with treated hypertension scored lower by 0.50 units (95%CI:-0.69,-0.31); however, the APOE e4 allele carriers with untreated hypertension scored lower by 1.02 units on the TICS score (95%CI:-1.29, -0.76).
|
31697783 |
2019 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
In pairings of APOE*4 with hypertension (HTN) and congestive heart failure (CHF), the variables contributed independently and additively to all-cause dementia risk.
|
31455442 |
2019 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
APOE polymorphism is associated with blood lipid and serum uric acid metabolism in hypertension or coronary heart disease in a Chinese population.
|
31559922 |
2019 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
A propensity score analysis was used to model the association of APOE with the burden of hypertension across race/ethnic groups.
|
30726504 |
2019 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
GWASCAT |
Genetic heterogeneity of Alzheimer's disease in subjects with and without hypertension.
|
31055733 |
2019 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
We used a mouse model of sympathetic nervous system-driven hypertension on the atherosclerotic-prone apolipoprotein E-deficient background.
|
30361420 |
2019 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Exploiting Drug-Apolipoprotein E Gene Interactions in Hypertension to Preserve Cognitive Function: The 3-City Cohort Study.
|
30292766 |
2019 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Altered FBS was found in 28.3% of the participants, hypertension in 57.6% and APOE4 in 32.0%.
|
30205523 |
2018 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
In multivariable analysis, baseline hypertension (hazard ratio [HR], 1.30; 95% CI, 1.09-1.55), diabetes (HR, 1.45; 95% CI, 1.17-1.80), smoking (HR, 1.09; 95% CI, 1.01-1.17), apolipoprotein E ε4 genotype (1 allele HR, 1.22; 95% CI, 1.02-1.45; 2 alleles HR, 1.95; 95% CI, 1.35-2.81), and incident stroke (HR, 3.38; 95% CI, 2.78-4.10) and dementia (HR, 2.56; 95% CI, 2.11-3.12) were associated with an increased risk of late-onset epilepsy, while higher levels of physical activity (HR, 0.90; 95% CI, 0.83-0.98) and moderate alcohol intake (HR, 0.72; 95% CI, 0.57-0.90) were associated with a lower risk.
|
30039175 |
2018 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
For ApoE genotypes, compared with ε3/ε3 genotype, genotypes (ε2/ε2 and ε2/ε3) showed a possible association with hypertension (OR = 0.88; 95% CI: 0.79-0.99; P = 0.033), and genotypes (ε3/ε4 and ε4/ε4) had a 2.08-fold risk of developing hypertension (OR = 2.08; 95% CI: 1.58-2.74; P < 0.001).
|
30180966 |
2018 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Consecutive outpatients with late-onset AD were assessed for APOE haplotypes and the following potential baseline predictors: gender, schooling, age at dementia onset, lifetime urban living and sanitary conditions, occupational complexity, cognitive and physical activities, cerebrovascular risk factors (obesity, lifetime alcohol use and smoking, length of arterial hypertension, diabetes mellitus, and a dyslipidemic profile), use of a pacemaker, creatinine clearance, body mass index, waist circumference, head traumas with unconsciousness, treated systemic bacterial infections, amount of surgical procedures under general anesthesia, and family history of AD.
|
30149448 |
2018 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
The findings may contribute to clarify the mechanisms of development of postmenopausal hypertension and the link between RAAS and apolipoprotein E.
|
28987631 |
2017 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
This study shows the relevance of polymorphisms in APOB (odds ratio (OR), 1.17; 95% confidence interval (95% CI), 0.74-1.85), APOC3 (OR, 1.33; 95% CI, 0.82-2.17) and APOE (OR, 1.75; 95% CI, 1.09-2.80), as genetic risk markers for hypercholesterolemia; polymorphisms in ACE (OR, 1.68; 95% CI, 0.32-8.77) and AGT (OR, 1.74; 95% CI, 0.97-3.14) for hypertension; and in APOE*3/*4 (OR, 2.06; 95% CI, 1.70-2.51) and APOE*4/*4 (OR, 3.08; 95% CI, 1.85-5.12) as unambiguous markers of dementia.
|
29081697 |
2017 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
To determine 1) age-adjusted transition probabilities to worsening physical/cognitive function states, reversal to normal cognition/physical function, or maintenance of normal state; 2) whether these transitions are modulated by sex, BMI, education, hypertension (HTN), health status, or APOE4; 3) whether worsening gait speed preceded cognition change, or vice versa.
|
28244566 |
2017 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Those with Alzheimer's disease-related cognitive impairment were younger, more likely to have a positive PiB-PET scan and carry at least one apolipoprotein E ɛ4 allele; those with subcortical vascular cognitive impairment were more likely to have hypertension, diabetes mellitus, hyperlipidaemia, prior stroke, lacunes, deep microbleeds, and carry the apolipoprotein E ɛ3 allele.
|
28335021 |
2017 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy.
|
28344760 |
2017 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Interactions with APOE-ε4 and hypertension were assessed.
|
27556935 |
2017 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
APOE ɛ4 remained significant (OR: 2.37; 95% CI: 1.37, 4.07), as did hypertension (OR: 0.55; 95% CI: 0.32, 0.93).
|
28578665 |
2017 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Black race (hazard ratio [HR], 1.36; 95% CI, 1.21-1.54), older age (HR, 8.06; 95% CI, 6.69-9.72 for participants aged 60-66 years), lower educational attainment (HR, 1.61; 95% CI, 1.28-2.03 for less than a high school education), and APOE ε4 genotype (HR, 1.98; 95% CI, 1.78-2.21) were associated with increased risk of dementia, as were midlife smoking (HR, 1.41; 95% CI, 1.23-1.61), diabetes (HR, 1.77; 95% CI, 1.53-2.04), prehypertension (HR, 1.31; 95% CI, 1.14-1.51), and hypertension (HR, 1.39; 95% CI, 1.22-1.59).
|
28783817 |
2017 |