Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
We created a MI model in 16-week-old male apolipoprotein E-deficient mice (<i>n</i> = 42), which were randomly assigned to exercise group (MI-Ex) and sedentary group (MI-Sed).
|
30857427 |
2020 |
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
In general, our findings reveal a critical role of apolipoprotein E in regulating Ly6G<sup>+</sup> neutrophil activation and NET formation, resulting in limiting myocardial injury after myocardial infarction.
|
31249639 |
2019 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We recently described that apolipoprotein E (ApoE) deficient mice with a mutation in the fibrillin-1 (Fbn1) gene (ApoE<sup>-/-</sup>Fbn1<sup>C1039G+/-</sup>) develop accelerated atherosclerosis, plaque rupture, myocardial infarction, cerebral hypoxia and sudden death.
|
31085310 |
2019 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The effect of the APOE e4-allele on the association between lifestyle factors (smoking, physical activity, being overweight, occupational attainment) and cognitive performance (trail making test [TMT] B, verbal fluency test [VFT]) was analyzed via multivariate generalized linear modeling adjusted for APOE e2-allele, age, gender, education, stroke, and heart attack.
|
29215900 |
2018 |
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
APOE ε2 is a strong genetic determinant of low lipoprotein(a) concentrations but does not modify the causal association of lipoprotein(a) with myocardial infarction or aortic valve stenosis.
|
28651346 |
2017 |
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
We maintained apolipoprotein E-deficient mice on a high cholesterol diet and induced myocardial infarction by transient ligation at 4 weeks.
|
28397162 |
2017 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Corresponding HRs for highest versus lowest apoE tertile in ε33 carriers were 1.18 (1.03-1.36) for IHD and 1.21 (0.98-1.49) for MI in men, and 0.91 (0.78-1.06) and 0.93 (0.71-1.21) in women.
|
26761769 |
2016 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of apolipoprotein E gene polymorphism and susceptibility of myocardial infarction.
|
25111308 |
2014 |
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using microarray mRNA expression profiling, we identified genes whose expression in the hearts of dKO mice changed substantially during disease progression [at 21 d of age (no CAD), 31 d of age (small myocardial infarctions), and 43 d of age (extensive myocardial infarctions) vs. CAD-free SR-BI(+/-)/apoE(-/-) controls].
|
24082102 |
2013 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated a possible interaction of apolipoprotein E (APOE) gene with birthplace on the risk of myocardial infarction (MI) and coronary atherosclerosis.
|
23110590 |
2013 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between apolipoprotein E gene polymorphism and myocardial infarction.
|
23371373 |
2013 |
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
For the CDR-SB, there were 3-way interactions between the APOE ε4, time and either myocardial infarction (LR χ² = 17.83, 2 df, p = 0.0001) or stroke (LR χ² = 11.48, 2 df, p = 0.003.
|
21593560 |
2011 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E gene polymorphism and myocardial infarction.
|
18190985 |
2009 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Apo E isoform, and 2 common low-density lipoprotein receptor variants (rs1433099 and rs6511720) influence MI risk in this multiethnic sample.
|
20031563 |
2009 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that LRP8 R952Q variant may have an additive effect to APOE epsilon2/epsilon3/epsilon4 genotype in determining ApoE concentrations and risk of MI in an Italian population.
|
19439088 |
2009 |
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
LHGDN |
The aim of this study was to investigate the possibility of interactions between CETP, PPARA, APOE, and APOAI polymorphisms and HDL-C, apolipoprotein (apo) A-I, lipoprotein (Lp) A-I, and Lp A-I:A-II in a sample selected from the Prospective Epidemiological Study of Myocardial Infarction (PRIME) study population who remained free of cardiovascular events over 5 years of follow-up.
|
19217440 |
2009 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E Arg136 --> Cys in individuals with premature myocardial infarction.
|
19545491 |
2009 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E gene epsilon2/epsilon3/epsilon4 polymorphism and myocardial infarction: case-control study in a large population sample.
|
17433475 |
2008 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Apolipoprotein E gene epsilon2/epsilon3/epsilon4 polymorphism and myocardial infarction: case-control study in a large population sample.
|
17433475 |
2008 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In healthy blood donors and in patients with CAD complicated by myocardial infarction (MI) four apolipoprotein gene polymorphisms [APO (a) PNR, APO E, APO CI and APO CII] were determined and plasma levels of total homocysteine, total cholesterol (TC), triglycerides (TG), HDL-cholesterol (HLD-C) and apolipoproteins (apo A-I, Apo B, Apo E) were measured.
|
19014618 |
2008 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E polymorphisms influence effect of pravastatin on survival after myocardial infarction in a Mediterranean population: the GISSI-Prevenzione study.
|
17567623 |
2007 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study supports the hypothesis that the APOE*2 and APOE*4 variants increase susceptibility to MI in the presence of high saturated fat and could explain inconsistent findings on the effects of these variants on MI in various populations.
|
18494374 |
2007 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results indicated that carriers of APOE-epsilon4 allele have a distinct plasma lipids profile and carrier of this allele with low levels of HDL-C and with high levels of LDL-C may be susceptible to CAD and myocardial infarction specially in diabetic patients.
|
17689519 |
2007 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Acute myocardial infarction and proinflammatory gene variants.
|
18056971 |
2007 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In patients without hypercholesterolaemia, the APOE allele epsilon4 was highly predictive for the presence of premature MI (epsilon4 55% vs. epsilon3 45% vs. epsilon2 28%; P < 0.0001; hazard ratio 1.75, 95%CI 1.19-2.57).
|
17217375 |
2007 |