ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion.
|
28111074 |
2017 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Late-onset familial Alzheimer disease (LOFAD) is a genetically heterogeneous and complex disease for which only one locus, APOE, has been definitively identified.
|
15248153 |
2004 |
ALZHEIMER DISEASE 2
|
0.800 |
Biomarker
|
disease |
BEFREE |
We analyzed at the molecular level with presenilin-1 (PS-1) and apolipoprotein E (apoE) genotyping the affected subjects and asymptomatic relatives of an Italian family with several members affected by late-onset familial Alzheimer's disease (AD).
|
12037434 |
2002 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Interaction of the N-terminal domain of apolipoprotein E4 with heparin.
|
11258893 |
2001 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.
|
11447277 |
2001 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice.
|
10903326 |
2000 |
ALZHEIMER DISEASE 2
|
0.800 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E (apo E) epsilon4 is a risk factor for sporadic and late-onset familial Alzheimer's disease, but it is not well known whether the apo E is associated with spinocerebellar degeneration.
|
9667788 |
1998 |
ALZHEIMER DISEASE 2
|
0.800 |
Biomarker
|
disease |
BEFREE |
Others have confirmed this pattern of immunoreactivity in AD brain but did not observe an association with APOE4.
|
9258256 |
1997 |
ALZHEIMER DISEASE 2
|
0.800 |
Biomarker
|
disease |
BEFREE |
Population studies have established that one of the common isoforms of apolipoprotein E, the apoE4, is associated with higher incidence and earlier age of onset of late onset familial Alzheimer's disease (AD), whereas apoE2 may have the opposite effect.
|
9265639 |
1997 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein.
|
8939961 |
1996 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E alleles but neither apolipoprotein B nor apolipoprotein AI/CIII alleles are associated with late onset, familial Alzheimer's disease.
|
7609909 |
1995 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The most dramatic and unexpected finding in this regard was made in early 1993, when it was reported that the presence of the APOE*4 allele is a significant risk factor for the development of late-onset familial Alzheimer's disease, a debilitating brain disorder.
|
7729825 |
1995 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's Disease but is not causative.
|
7485228 |
1995 |
ALZHEIMER DISEASE 2
|
0.800 |
Biomarker
|
disease |
BEFREE |
These results strengthen the argument for a direct role of APOE in susceptibility to AD.
|
7713402 |
1995 |
ALZHEIMER DISEASE 2
|
0.800 |
Biomarker
|
disease |
BEFREE |
Results showed that > 80% of apoE4-negative AD patients showed marked improvement after 30 weeks as measured by the AD assessment scale (ADAS), whereas 60% of apoE4 carriers had ADAS scores that were worse compared to baseline.
|
8618881 |
1995 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms.
|
8071364 |
1994 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.
|
7972031 |
1994 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease.
|
7891887 |
1994 |
ALZHEIMER DISEASE 2
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
ApoE isoforms may play an important role in the metabolism of beta-peptide, and APOE epsilon 4 may operate as a susceptibility gene (risk factor) for the clinical expression of AD.
|
8350998 |
1993 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
An increased prevalence of apolipoprotein E (ApoE) epsilon 4 allele exists in late onset familial Alzheimer's disease.
|
8398148 |
1993 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
|
8346443 |
1993 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.
|
8367470 |
1993 |
ALZHEIMER DISEASE 2
|
0.800 |
Biomarker
|
disease |
BEFREE |
A functional role of the apolipoprotein E-E4 isoform in the pathogenesis of late-onset familial Alzheimer disease is suggested.
|
8446617 |
1993 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The gene for apoE is on chromosome 19, within the genomic region previously associated with late-onset familial Alzheimer's disease (AD).
|
8103819 |
1993 |
ALZHEIMER DISEASE 2
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Nucleotide sequence and structure of the human apolipoprotein E gene.
|
2987927 |
1985 |