IGF2, insulin like growth factor 2, 3481

N. diseases: 604; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.330 GeneticVariation disease BEFREE Furthermore, human population studies have established significant associations between specific polymorphisms at the insulin-like growth factor II gene and obesity which is an important risk factor for atherosclerosis. 14501587 2003
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.330 Biomarker disease BEFREE However, there is comparatively little information on how IGF2 affects tumour growth and cardiovascular diseases such as atherosclerosis. 23257688 2013
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.330 Biomarker disease CTD_human First, we show that homozygosity for a disrupted insulin-like growth factor II allele in mice lacking apolipoprotein E, a widely used animal model of atherosclerosis, results in aortic lesions that are approximately 80% smaller and contain approximately 50% less proliferating cells compared with mice lacking only apolipoprotein E. Second, targeted expression of an insulin-like growth factor II transgene in smooth muscle cells, but not the mere elevation of circulating levels of the peptide, causes per se aortic focal intimal thickenings. 11726660 2002
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.330 Biomarker disease LHGDN Associations of blood levels of insulin-like growth factor (IGF)-I, IGF-II and IGF binding protein (IGFBP)-3 in schizophrenic Arab subjects. 17635080 2007