Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.330 Biomarker disease BEFREE However, there is comparatively little information on how IGF2 affects tumour growth and cardiovascular diseases such as atherosclerosis. 23257688 2013
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.330 Biomarker disease LHGDN IGF-II metabolism may play a role in atherogenesis in in schizophrenic Arab subjects 17635080 2007
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.330 Biomarker disease BEFREE Insulin-like growth factor II and its receptors in atherosclerosis and in conditions predisposing to atherosclerosis. 14501587 2004
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.330 Biomarker disease CTD_human Here, we provide two sources of genetic evidence for a novel, pivotal role of locally produced insulin-like growth factor II in the development of atherosclerosis. 11726660 2002
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.330 Biomarker disease CTD_human Insulin-like growth factor II plays a central role in atherosclerosis in a mouse model. 11726660 2002
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.330 Biomarker disease CTD_human First, we show that homozygosity for a disrupted insulin-like growth factor II allele in mice lacking apolipoprotein E, a widely used animal model of atherosclerosis, results in aortic lesions that are approximately 80% smaller and contain approximately 50% less proliferating cells compared with mice lacking only apolipoprotein E. Second, targeted expression of an insulin-like growth factor II transgene in smooth muscle cells, but not the mere elevation of circulating levels of the peptide, causes per se aortic focal intimal thickenings. 11726660 2002