Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.040 Biomarker disease BEFREE Among the genes in the turquoise module, COL5A2 (collagen, type V, alpha 2) could be regulated by PBX (pre-B-cell leukemia homeobox 1)1/2 and HOXB1(homeobox B1) transcription factors to be involved in the focal adhesion pathway; CENP-E (centromere protein E, 312kDa) by E2F4 (E2F transcription factor 4, p107/p130-binding); MYCN (v-myc myelocytomatosis viral related oncogene, neuroblastoma derived [avian]) by PAX5 (paired box 5); and BCL-2 (B-cell CLL/ lymphoma 2) and IGFBP-6 (insulin-like growth factor binding protein 6) by GLI1. 23167388 2012
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.040 Biomarker disease BEFREE This study therefore shows that IGFBP-6 plays a role in neuroblastoma cell growth in vivo and in vitro and that stable overexpression of IGFBP-6 leads to alteration of the initial balance between the IGFBPs. 11874695 2002
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.040 Biomarker disease BEFREE Since IGFBP-6 secretion is associated with the arrest of proliferation in neuroblastoma cells and is regulated by the combined actions of differentiation factors, we subcloned the proximal promoter of human IGFBP-6 (nt -766/+1) into a pCAT expression vector so as to examine modulation of its transcriptional activity. 11161966 2000
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.040 Biomarker disease BEFREE Our findings show that IGFBP-6 influences neuroblastoma cell growth, both in vitro and in experimental xenograft development. 9563481 1998