Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
SH-SY5Y neuroblastoma cells transfected with the amyloid precursor protein (APP) gene containing the Swedish mutations causing familial AD (APPswe), were used as a model to explore the effect of Aβ pathology on 5-HT1B and related molecules including the receptor adaptor protein (p11), SERT and MAOA gene expression, and MAOA activity after treatment with selective serotonin reuptake inhibitor (SSRI) (sertraline), and a 5-HT1B receptor antagonist.
|
27163814 |
2016 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The γ-secretase-mediated cleavage of the APP C-terminal membrane stub leads to the production of various amyloid β (Aβ) species.
|
28332150 |
2018 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, [18F]-FDG positron emission tomography was used to study age-related changes of cerebral glucose utilization under resting conditions in 3-, 6-, and 12-month-old APP(SweLon)/PS1(M146L), a mouse model of amyloidosis.
|
22079157 |
2012 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Amyloid is mainly composed by amyloid-beta (A(beta)) peptides, which are derive from processing of the beta-amyloid precursor protein (APP), better named amyloid-beta precursor protein (A(beta)PP), by secretases.
|
15983050 |
2005 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the beta-amyloid (Abeta) sequence of the amyloid precursor protein gene (APP) present with variable disease phenotypes.
|
12505425 |
2002 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Point mutations of APP affecting Aβ production are found to be causal for hereditary early onset familial AD.
|
21769132 |
2012 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previously, we have documented that prenatal hypoxia can aggravate the cognitive impairment and Alzheimer's disease (AD) neuropathology in APP(Swe) /PS1(A246E) (APP/PS1) transgenic mice, and valproic acid (VPA) can prevent hypoxia-induced down-regulation of β-amyloid (Aβ) degradation enzyme neprilysin (NEP) in primary neurons.
|
24289518 |
2014 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We orally administered the flavonoid tannic acid (TA) to the transgenic PSAPP mouse model of cerebral amyloidosis (bearing mutant human APP and presenilin-1 transgenes) and evaluated cognitive function and AD-like pathology.
|
22219198 |
2012 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
E22Q-mutant Abeta peptide (AbetaDutch) increases vascular but reduces parenchymal Abeta deposition.
|
19218342 |
2009 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Microglial activity decreases relative to ongoing amyloidosis with aging in APP-SL70 mice.
|
30400912 |
2018 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Differential processing of the amyloid precursor protein liberates either amyloid-ß, a causative agent of Alzheimer's disease, or secreted amyloid precursor protein-alpha (sAPPα), which promotes neuroprotection, neurotrophism, neurogenesis and synaptic plasticity.
|
23742273 |
2013 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Novel APP K724M mutation causes Chinese early-onset familial Alzheimer's disease and increases amyloid-β42 to amyloid-β40 ratio.
|
25018108 |
2014 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Presentation of amyloidosis in carriers of the codon 692 mutation in the amyloid precursor protein gene (APP692).
|
11004129 |
2000 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found that synaptic depression induced by oxygen glucose deprivation (OGD) was enhanced in EC slices either in presence of synthetic oligomeric Aβ or in slices from mutant human amyloid precursor protein transgenic mice (mhAPP J20).
|
24966375 |
2014 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Arctic mutation (p.E693G/p.E22G)fs within the β-amyloid (Aβ) region of the β-amyloid precursor protein gene causes an autosomal dominant disease with clinical picture of typical Alzheimer's disease.
|
24252272 |
2013 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Differential expression of the amyloid precursor protein gene (APP) may be important in the development of amyloidosis in Alzheimer's disease (AD) and experimentally in the brain's response to injury.
|
10675649 |
2000 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Further experimentation confirmed that in CHO cells expressing APPswe or wild-type APP (APPwt), co-expression of LRP1-CT C4408R decreases Aβ and increases sAPPα and α-CTF compared with co-expression of wild-type LRP1-CT.
|
28612181 |
2017 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This is the first report to show decreased Aβ levels in plasma in APP A673T carriers and thus provides evidence that lower Aβ levels throughout life may be protective against AD.Ann Neurol 2017;82:128-132.
|
28556232 |
2017 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
They were not co-labeled with two Aβ C-terminal antibodies (Ter40, Ter42), nor associated with extracellular amyloidosis.
|
22542680 |
2012 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Presenilin mediates the proteolytic cleavage of the β-amyloid precursor protein to release β-amyloid, and mutations in presenilin can cause familial Alzheimer disease.
|
21239495 |
2011 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we show that absence of TYROBP/DAP12 in a mouse model of AD-type cerebral Aβ amyloidosis (APP<sup>KM670/671NL</sup>/PSEN1<sup>Δexon9</sup>) recapitulates the expected network characteristics by normalizing the transcriptome of APP/PSEN1 mice and repressing the induction of genes involved in the switch from homeostatic microglia to disease-associated microglia (DAM), including Trem2, complement (C1qa, C1qb, C1qc, and Itgax), Clec7a and Cst7.
|
30283032 |
2019 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
After 7 months of dietary intervention, we found that fish oil supplementation improved behavioral performance, alleviated brain beta-amyloid (Aβ) plaque burden, and attenuated the oxidative stress in APP/PS1 mice by increasing cortical GSH content and total antioxidant capacity, as well as by decreasing MDA level.
|
29656360 |
2018 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Neurons from mutant hiPSC lines express PSEN1-A246E mutations themselves and show AD-like biochemical features, that is, amyloidogenic processing of amyloid precursor protein (APP) indicated by an increase in β-amyloid (Aβ)42/Aβ40 ratio.
|
25027006 |
2014 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Studies of the beta-amyloid precursor protein (APP), which gives rise to beta-amyloid, are rapidly leading to a better understanding of the biochemical basis of the disease--a prerequisite for rational drug development.
|
8140621 |
1994 |
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The different metabolites generated from these pathways, including soluble APPα (sAPPα), soluble APPβ (sAPPβ), β-amyloid (Aβ) peptides and the APP intracellular domain (AICD), have different functions determined by their structural differences, equilibrium and concentration with respect to other fragments derived from APP.
|
29383688 |
2018 |