|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The lower titer of serum anti-Abeta42 peptide antibodies in AD patients may reflect the reported specific impairment of helper T cell activity for B cells that produce anti-amyloid-beta42 peptide antibodies in APP-transgenic mice.
|
12086704 |
2002 |
|
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
SH-SY5Y neuroblastoma cells transfected with the amyloid precursor protein (APP) gene containing the Swedish mutations causing familial AD (APPswe), were used as a model to explore the effect of Aβ pathology on 5-HT1B and related molecules including the receptor adaptor protein (p11), SERT and MAOA gene expression, and MAOA activity after treatment with selective serotonin reuptake inhibitor (SSRI) (sertraline), and a 5-HT1B receptor antagonist.
|
27163814 |
2016 |
|
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The γ-secretase-mediated cleavage of the APP C-terminal membrane stub leads to the production of various amyloid β (Aβ) species.
|
28332150 |
2018 |
|
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, [18F]-FDG positron emission tomography was used to study age-related changes of cerebral glucose utilization under resting conditions in 3-, 6-, and 12-month-old APP(SweLon)/PS1(M146L), a mouse model of amyloidosis.
|
22079157 |
2012 |
|
Amyloidosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The finding showed that, accompanied with the inhibition on the level of Aβ<sub>1-42</sub> in primary neurons and APP/PS1 transgenic mice, geniposide induced the phosphorylation of JAK2 and STAT3, regulated the expression level of α- and β-secretase, and all of these could be prevented by the pre-incubation with LA.
|
28160136 |
2017 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
TNF-α upregulates macroautophagic processing of APP/β-amyloid in a human rhabdomyosarcoma cell line.
|
23294492 |
2013 |
|
Amyloidosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Recently, we reported that presenilin 1 considerably increased the expression level of U1 small nuclear RNA (snRNA) accompanied with the adverse change of amyloid precursor protein (APP) expression, β-amyloid (Aβ) production and cell apoptosis.
|
29395359 |
2018 |
|
Amyloidosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Extracellular, interstitial fluid (ISF) Aβ levels were measured in the hippocampus of APP/PS1 mice.
|
27069115 |
2016 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We then used Western blotting, ELISA and immunohistochemistry to detect intra- and extracellular protein levels of endocytic-related proteins, APP and APP metabolites including β-amyloid (Aβ).
|
27430330 |
2016 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The amyloid forming beta-peptide of Alzheimer's disease is synthesized as part of a larger integral membrane precursor protein (beta APP) of which three alternatively spliced versions of 695, 751, and 770 amino acids have been described.
|
1968460 |
1990 |
|
Amyloidosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To address this question, we characterised the morphology, biochemistry and functionality of brain blood vessels in transgenic arctic β-amyloid (arcAβ) mice expressing human amyloid precursor protein (APP) with both the familial AD-causing Swedish and Arctic mutations; these mice are characterised by strong CAA pathology.
|
21688176 |
2011 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ex vivo intrinsic clotting of plasma from AD mice expressing human amyloid precursor protein (APP) was also delayed in an age-dependent manner, suggesting that this phenotype is related to APP, the parent protein of Aβ.
|
29700007 |
2018 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Unexpectedly, the antibodies to the carboxyl terminus of beta APP labeled amyloid-containing senile plaques in AD brain.
|
3140239 |
1988 |
|
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Amyloid is mainly composed by amyloid-beta (A(beta)) peptides, which are derive from processing of the beta-amyloid precursor protein (APP), better named amyloid-beta precursor protein (A(beta)PP), by secretases.
|
15983050 |
2005 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chronic cSNK peptide immunization of APP/PS1 mice engendered an anti-AβO<sup>cSNK</sup> IgG1 response without epitope spreading to Aβ monomers or fibrils and was accompanied by preservation of global PSD95 expression and improved cued fear memory.
|
29614860 |
2018 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the cell cultures, baicalein significantly reduced the production of β-amyloid (Aβ) by increasing APP α-processing.
|
23686791 |
2013 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
To enhance the process of protein secretion and accumulation, we adopted a chemical strategy of induction to modulate post-translational pathways of APP using an Amyloid-β Forty-Two Inducer named Aftin-5.
|
30557391 |
2018 |
|
Amyloidosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
An alternative model of amyloidosis utilizes intracerebroventricular infusion of thiorphan or phosphoramidon to block the activity of key Aβ degrading enzymes (NEP, NEP2) resulting in accumulation of Aβ.
|
20941644 |
2011 |
|
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the beta-amyloid (Abeta) sequence of the amyloid precursor protein gene (APP) present with variable disease phenotypes.
|
12505425 |
2002 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The accumulation of amyloid beta (Aβ) peptide (Amyloid cascade hypothesis), an APP protein cleavage product, is a leading hypothesis in the etiology of Alzheimer's disease (AD).
|
28985224 |
2017 |
|
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Point mutations of APP affecting Aβ production are found to be causal for hereditary early onset familial AD.
|
21769132 |
2012 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alternatively, APP can be cleaved by α-secretase within the Aβ domain to release soluble APPα and preclude Aβ generation.
|
21214928 |
2011 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
β-amyloid (Aβ) peptide, accumulation of which is a culprit for Alzheimer's disease (AD), is derived from the initial cleavage of amyloid precursor protein by the aspartyl protease BACE1.
|
23951005 |
2013 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The details of trafficking and processing of APP to Aβ, the cytosolic intracellular Aβ domain (AICD) and small soluble proteins are shown, together with other amyloid-forming proteins such as tau and α-synuclein (α-syn).
|
30605056 |
2019 |
|
Amyloidosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lead exposure increases levels of β-amyloid in the brain and CSF and inhibits LRP1 expression in APP transgenic mice.
|
21167913 |
2011 |