Presenile dementia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, as activation of δ-opioid receptor by a non-peptidic δ-opioid receptor agonist also modulates the expression, maturation and processing of amyloid precursor protein and β-secretase activity, the potential role of these effects on ischemic stroke caused dementia or Alzheimer's disease are also discussed.
|
31535637 |
2020 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to examine the association between cognitive function and several serum miRNAs levels related to amyloid precursor protein (APP) proteolysis in a Japanese general population who had never been diagnosed with dementia.
|
30802839 |
2020 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cystatin isolated from chicken egg white, called ovocystatin, has been widely used in the medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. The aim of this study was to assess the effect of administering ovocystatin on the development of dementia-specific cognitive deficits in APP/PS1 transgenic mice.
|
30504006 |
2019 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, we exposed an AD-relevant mouse model (APP/PS1 KI) to chronic intermittent hypoxia (IH) (an experimental model of sleep apnea) to begin to describe one of the potential mechanisms by which SDB could increase the risk of dementia.
|
30529693 |
2019 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The evidence that a pathogenic APP mutation causes an early enhancement of BAD-Glu suggests that alterations of BACE1 processing of APP in glutamatergic synaptic vesicles could contribute to dementia.
|
31496118 |
2019 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Amyloid PET pattern with dementia and amyloid angiopathy in Taiwan familial AD with D678H APP mutation.
|
30703749 |
2019 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
2) Family members with codon 717 APP mutations and dementia have low serum vitamin B12 values.
|
30814347 |
2019 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Neuropsychiatric symptoms have been reported as prodromal symptoms of AD-like dementia and soluble forms of beta amyloid peptide (Aβ), the main constituent of insoluble plaques typical of AD brains, have been implicated in such an effect.
|
29879605 |
2018 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
BACE1 activity and sAβPPβ concentration were measured in patients with AD dementia (n = 56) and mild cognitive impairment (MCI) due to AD (n = 76) with abnormal routine AD CSF markers, in patients with MCI with normal CSF markers (n = 39), and in controls without preclinical AD (n = 48).
|
29788013 |
2018 |
Presenile dementia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We explored how levels of endocytic proteins, APP, its metabolites, secretase enzymes, and tau varied with age in cortical brain samples from men of three age ranges (young [20-30], middle aged [45-55], and old [70-90]) with no symptoms of dementia.
|
28655199 |
2018 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
High performance plasma amyloid-β biomarkers for Alzheimer's disease.
|
29420472 |
2018 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Scrutiny of the evidence generated so far reveals and a lack of understanding of the wider APP proteolytic system and how narrow research into the dementia syndrome has been to date.
|
30246866 |
2018 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
APP is involved in the pathology of Alzheimer's disease (AD), the most common neurodegenerative disorder causing dementia.
|
29383688 |
2018 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers.
|
30320580 |
2018 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We review current knowledge on clinical diagnosis and presentation of dementia in DS in comparison with FAD due to APP mutations and APP duplication.
|
28870521 |
2018 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Also problematic is the alternative hypothesis that, instead of amyloid plaques, it is oligomers of amyloid precursor protein that cause AD.Evidence is presented suggesting amyloid/oligomers as necessary but insufficient causes of the dementia and that, for dementia to develop, requires the addition of cofactors known to be associated with AD.
|
28509380 |
2018 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alzheimer's disease (AD) is the most common cause of dementia and is likely caused by defective amyloid precursor protein (APP) trafficking and processing in neurons leading to amyloid plaques containing the amyloid-β (Aβ) APP peptide byproducts.
|
28360834 |
2017 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
An elderly man with phenotypic DS and partial trisomy of chromosome 21 (PT21) lacked triplication of APP affording an opportunity to study the role of this gene in the pathogenesis of dementia.
|
27983553 |
2017 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Participants from five families with early-onset autosomal-dominant mutations (Swedish and Arctic APP, PSEN1 M146V, H163Y, and I143T) included 35 carriers (28 without dementia and 7 with) and 44 non-carriers.
|
28079014 |
2017 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease.
|
28448946 |
2017 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations in amyloid β precursor protein (APP) gene alter APP processing, either causing familial Alzheimer's disease (AD) or protecting against dementia.
|
28626014 |
2017 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.
|
27117003 |
2016 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Trisomy 21 and the consequent extra copy of the amyloid precursor protein (APP) gene and increased beta-amyloid (Aβ) peptide production underlie the universal development of Alzheimer's disease (AD) pathology and high risk of AD dementia in people with Down syndrome (DS).
|
26651340 |
2016 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Given the absence of PSEN1, PSEN2 and APP causative variants, we investigated whether these 260 patients might be burdened with protein-modifying variants in 20 genes that were previously shown to cause other types of dementia when mutated.
|
26242991 |
2016 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis.
|
25352456 |
2015 |